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    DNAJA2 DnaJ heat shock protein family (Hsp40) member A2 [ Homo sapiens (human) ]

    Gene ID: 10294, updated on 21-Apr-2019

    Summary

    Official Symbol
    DNAJA2provided by HGNC
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member A2provided by HGNC
    Primary source
    HGNC:HGNC:14884
    See related
    Ensembl:ENSG00000069345 MIM:611322
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DJ3; CPR3; DJA2; DNAJ; DNJ3; RDJ2; HIRIP4; PRO3015
    Summary
    The protein encoded by this gene belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain. The product of this gene works as a cochaperone of Hsp70s in protein folding and mitochondrial protein import in vitro. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 26.8), heart (RPKM 23.4) and 25 other tissues See more
    Orthologs

    Genomic context

    See DNAJA2 in Genome Data Viewer
    Location:
    16q11.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (46955362..46973714, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (46989274..47007625, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene creatine kinase B pseudogene 1 Neighboring gene small nucleolar RNA, C/D box 148 Neighboring gene glutamic--pyruvic transaminase 2 Neighboring gene neuropilin and tolloid like 2 Neighboring gene ITFG1 antisense RNA 1 Neighboring gene ribosomal protein L23a pseudogene 72

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of DnaJ (Hsp40) homolog, subfamily A, member 2 (DNAJA2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif interacts with DNAJA2; interaction predicted to be relevant in protein folding and/or macromolecular structure assembly PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chaperone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    heat shock protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    unfolded protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    positive regulation of ATPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    protein refolding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to heat IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome HDA PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    dnaJ homolog subfamily A member 2
    Names
    DnaJ (Hsp40) homolog, subfamily A, member 2
    HIRA interacting protein 4
    cell cycle progression 3 protein
    cell cycle progression restoration gene 3 protein
    renal carcinoma antigen NY-REN-14

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005880.4NP_005871.1  dnaJ homolog subfamily A member 2

      See identical proteins and their annotated locations for NP_005871.1

      Status: REVIEWED

      Source sequence(s)
      AC018845, BC015809, BU677823, DB097731
      Consensus CDS
      CCDS10726.1
      UniProtKB/Swiss-Prot
      O60884
      UniProtKB/TrEMBL
      A0A024R6S1
      Related
      ENSP00000314030.5, ENST00000317089.10
      Conserved Domains (1) summary
      cl28246
      Location:4412
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

      Range
      46955362..46973714 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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