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    RGS19 regulator of G protein signaling 19 [ Homo sapiens (human) ]

    Gene ID: 10287, updated on 6-Jun-2024

    Summary

    Official Symbol
    RGS19provided by HGNC
    Official Full Name
    regulator of G protein signaling 19provided by HGNC
    Primary source
    HGNC:HGNC:13735
    See related
    Ensembl:ENSG00000171700 MIM:605071; AllianceGenome:HGNC:13735
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GAIP; RGSGAIP
    Summary
    G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in spleen (RPKM 10.5), bone marrow (RPKM 8.6) and 21 other tissues See more
    Orthologs
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    Genomic context

    See RGS19 in Genome Data Viewer
    Location:
    20q13.33
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (64073181..64079964, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (65893259..65900019, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (62704534..62711317, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13204 Neighboring gene SOX18 promoter region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62684293-62684982 Neighboring gene SRY-box transcription factor 18 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62686363-62687052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62687053-62687742 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62688433-62689122 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62689123-62689810 Neighboring gene transcription elongation factor A2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18262 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18263 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13205 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13206 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13207 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:62711846-62712019 Neighboring gene microRNA 6813 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13208 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13209 Neighboring gene opioid related nociceptin receptor 1 Neighboring gene LKAAEAR motif containing 1 Neighboring gene MPRA-validated peak4324 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62723260-62723993 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62723994-62724726 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62732783-62733284 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62738466-62738966 Neighboring gene neuropeptides B and W receptor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G-protein alpha-subunit binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in small GTPase-mediated signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in brush border IEA
    Inferred from Electronic Annotation
    more info
     
    located_in clathrin-coated vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    regulator of G-protein signaling 19
    Names
    G alpha interacting protein
    G protein signalling regulator 19
    guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein
    regulator of G-protein signalling 19

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039467.2NP_001034556.1  regulator of G-protein signaling 19

      See identical proteins and their annotated locations for NP_001034556.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR exon, as compared to variant 1.
      Source sequence(s)
      BC001318, BM554550
      Consensus CDS
      CCDS13555.1
      UniProtKB/Swiss-Prot
      A8K216, E1P5G9, P49795, Q53XN0, Q8TD60
      UniProtKB/TrEMBL
      Q6I9S5
      Related
      ENSP00000333194.5, ENST00000332298.9
      Conserved Domains (1) summary
      cd08745
      Location:87204
      RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein
    2. NM_005873.3NP_005864.1  regulator of G-protein signaling 19

      See identical proteins and their annotated locations for NP_005864.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the longer transcript.
      Source sequence(s)
      AF285097, AL590548, BC063010
      Consensus CDS
      CCDS13555.1
      UniProtKB/Swiss-Prot
      A8K216, E1P5G9, P49795, Q53XN0, Q8TD60
      UniProtKB/TrEMBL
      Q6I9S5
      Related
      ENSP00000378483.1, ENST00000395042.2
      Conserved Domains (1) summary
      cd08745
      Location:87204
      RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      64073181..64079964 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005260183.3XP_005260240.1  regulator of G-protein signaling 19 isoform X3

      See identical proteins and their annotated locations for XP_005260240.1

      UniProtKB/TrEMBL
      B4DP94, Q6I9S5
      Conserved Domains (1) summary
      cd08745
      Location:65182
      RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein
    2. XM_047439824.1XP_047295780.1  regulator of G-protein signaling 19 isoform X2

      UniProtKB/Swiss-Prot
      A8K216, E1P5G9, P49795, Q53XN0, Q8TD60
      UniProtKB/TrEMBL
      Q6I9S5
    3. XM_005260182.4XP_005260239.1  regulator of G-protein signaling 19 isoform X3

      See identical proteins and their annotated locations for XP_005260239.1

      UniProtKB/TrEMBL
      B4DP94, Q6I9S5
      Conserved Domains (1) summary
      cd08745
      Location:65182
      RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein
    4. XM_011528485.3XP_011526787.1  regulator of G-protein signaling 19 isoform X2

      See identical proteins and their annotated locations for XP_011526787.1

      UniProtKB/Swiss-Prot
      A8K216, E1P5G9, P49795, Q53XN0, Q8TD60
      UniProtKB/TrEMBL
      Q6I9S5
      Conserved Domains (1) summary
      cd08745
      Location:87204
      RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein
    5. XM_011528484.3XP_011526786.1  regulator of G-protein signaling 19 isoform X1

      UniProtKB/TrEMBL
      Q6I9S5
      Conserved Domains (1) summary
      cd08745
      Location:116233
      RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      65893259..65900019 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322828.1XP_054178803.1  regulator of G-protein signaling 19 isoform X3

      UniProtKB/TrEMBL
      B4DP94, Q6I9S5
    2. XM_054322827.1XP_054178802.1  regulator of G-protein signaling 19 isoform X2

      UniProtKB/Swiss-Prot
      A8K216, E1P5G9, P49795, Q53XN0, Q8TD60
      UniProtKB/TrEMBL
      Q6I9S5
    3. XM_054322826.1XP_054178801.1  regulator of G-protein signaling 19 isoform X2

      UniProtKB/Swiss-Prot
      A8K216, E1P5G9, P49795, Q53XN0, Q8TD60
      UniProtKB/TrEMBL
      Q6I9S5
    4. XM_054322829.1XP_054178804.1  regulator of G-protein signaling 19 isoform X3

      UniProtKB/TrEMBL
      B4DP94, Q6I9S5
    5. XM_054322825.1XP_054178800.1  regulator of G-protein signaling 19 isoform X1

      UniProtKB/TrEMBL
      Q6I9S5