U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    SPDYE16 speedy/RINGO cell cycle regulator family member E16 [ Homo sapiens (human) ]

    Gene ID: 102723555, updated on 25-Nov-2025
    Official Symbol
    SPDYE16provided by HGNC
    Official Full Name
    speedy/RINGO cell cycle regulator family member E16provided by HGNC
    Primary source
    HGNC:HGNC:51512
    See related
    Ensembl:ENSG00000185040 AllianceGenome:HGNC:51512
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable protein kinase binding activity. [provided by Alliance of Genome Resources, Jul 2025]
    Expression
    Broad expression in testis (RPKM 3.6), skin (RPKM 1.1) and 24 other tissues See more
    NEW
    Try the new Gene table
    Try the new Transcript table
    See SPDYE16 in Genome Data Viewer
    Location:
    7q11.23
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (76531313..76543297, complement)
    RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (77810549..77822535, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (76160630..76172614, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:76114631-76115532 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:76115533-76116434 Neighboring gene uncharacterized LOC124901675 Neighboring gene farnesyl diphosphate synthase pseudogene 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:76138251-76138456 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:76139334-76139906 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:76139907-76140479 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:76141233-76141884 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:76142537-76143186 Neighboring gene deltex E3 ubiquitin ligase 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:76141885-76142536 Neighboring gene uroplakin 3B Neighboring gene long intergenic non-protein coding RNA 3009 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:76234980-76235481 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:76235482-76235982 Neighboring gene 7q11.23 distal recombination region Neighboring gene ReSE screen-validated silencer GRCh37_chr7:76261368-76261573 Neighboring gene POM121 and ZP3 fusion Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:76302620-76303188 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:76357185-76358384 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:76513437-76513979 Neighboring gene uncharacterized LOC105375358

    Go to nucleotide: Graphics FASTA GenBank

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Related articles in PubMed

    1. The DNA sequence of human chromosome 7. Hillier LW, et al. Nature, 2003 Jul 10. PMID 12853948
    2. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. Khanna R, et al. FEBS J, 2018 Jun. PMID 29676528
    3. Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism. Antoniali G, et al. Nat Commun, 2017 Oct 6. PMID 28986522, Free PMC Article
    4. Toward a complete human genome sequence. Sanger Center, et al. Genome Res, 1998 Nov. PMID 9847074
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Review eQTL and phenotype association data in this region using PheGenI

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    speedy protein E16
    Names
    WBSCR19-like protein 5-like
    putative speedy protein E16

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001351597.1 → NP_001338526.1  speedy protein E16 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC004980
      UniProtKB/Swiss-Prot
      A6NJR5
      Related
      ENSP00000488825.1, ENST00000515340.2
      Conserved Domains (1) summary
      pfam11357
      Location:154 → 308
      Spy1; Cell cycle regulatory protein

    2. NM_001394943.1 → NP_001381872.1  speedy protein E16 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC004980
      Consensus CDS
      CCDS94129.1
      UniProtKB/Swiss-Prot
      A6NNV3
      UniProtKB/TrEMBL
      A0A0J9YWM7
      Related
      ENSP00000487772.2, ENST00000633306.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      76531313..76543297 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017012887.3 → XP_016868376.1  speedy protein E16 isoform X1

      UniProtKB/Swiss-Prot
      A6NJR5
      Conserved Domains (1) summary
      pfam11357
      Location:154 → 308
      Spy1; Cell cycle regulatory protein

    2. XM_047419718.1 → XP_047275674.1  speedy protein E16 isoform X2

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187561.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      18207..30134 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328698.1 → XP_054184673.1  speedy protein E16 isoform X4

      UniProtKB/TrEMBL
      A0A0J9YYB4

    2. XM_054328697.1 → XP_054184672.1  speedy protein E16 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      77810549..77822535 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356996.1 → XP_054212971.1  speedy protein E16 isoform X1

      UniProtKB/Swiss-Prot
      A6NJR5
      UniProtKB/TrEMBL
      A0A0J9YW45

    2. XM_054356997.1 → XP_054212972.1  speedy protein E16 isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6NNV3.4 GenPept UniProtKB/Swiss-Prot:A6NNV3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials