Tle7 TLE family member 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tle7provided by MGI
Official Full Name: TLE family member 7provided by MGI
Primary source: MGI:MGI:5439433
See related: Ensembl:ENSMUSG00000095941 AllianceGenome:MGI:5439433
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm21964
Summary: Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Orthologous to human TLE7 (TLE family member 7). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Low expression observed in reference dataset See more
Orthologs: all
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Genomic context

Location:: 8 D3; 8

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (110827964..110838646)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (110101332..110112014)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transducin-like enhancer protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001370839.1 → NP_001357768.1 transducin-like enhancer protein 7 isoform 2

Status: VALIDATED

Source sequence(s)

AC124409

Consensus CDS

CCDS90461.1

UniProtKB/TrEMBL

A0A1L1SR16

Related

ENSMUSP00000149275.2, ENSMUST00000213641.2

Conserved Domains (2) summary

COG2319
Location:146 → 422

WD40; WD40 repeat [General function prediction only]

sd00039
Location:152 → 191

7WD40; WD40 repeat [structural motif]
NM_001436223.1 → NP_001423152.1 transducin-like enhancer protein 7 isoform 1

Status: VALIDATED

Source sequence(s)

AC124409

UniProtKB/TrEMBL

A0A1W2P7S4