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    Dennd4a DENN/MADD domain containing 4A [ Mus musculus (house mouse) ]

    Gene ID: 102442, updated on 23-Jun-2021

    Summary

    Official Symbol
    Dennd4aprovided by MGI
    Official Full Name
    DENN/MADD domain containing 4Aprovided by MGI
    Primary source
    MGI:MGI:2142979
    See related
    Ensembl:ENSMUSG00000053641
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI115600; AI851943; F730015K02Rik
    Expression
    Broad expression in liver E14 (RPKM 9.5), liver E14.5 (RPKM 9.1) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Dennd4a in Genome Data Viewer
    Location:
    9; 9 C
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (64713408..64826949)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (64806124..64919667)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (64658818..64767474)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA glutamine 9 (anticodon CTG) Neighboring gene predicted gene, 36365 Neighboring gene predicted gene, 36459 Neighboring gene predicted gene, 24347 Neighboring gene solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 Neighboring gene predicted gene, 39361 Neighboring gene integrator complex subunit 14 Neighboring gene predicted gene, 25640

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Markers

    Homology

    Clone Names

    • MGC198792

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of Rab protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    C-myc promoter-binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162917.1NP_001156389.1  C-myc promoter-binding protein

      See identical proteins and their annotated locations for NP_001156389.1

      Status: VALIDATED

      Source sequence(s)
      AC140243
      Consensus CDS
      CCDS52834.1
      UniProtKB/TrEMBL
      E9Q8V6
      Conserved Domains (6) summary
      smart00801
      Location:560633
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:194276
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:811840
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:309493
      DENN; DENN (AEX-3) domain
      pfam10240
      Location:44207
      DUF2464; Multivesicular body subunit 12
      pfam13041
      Location:809849
      PPR_2; PPR repeat family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      64713408..64826949
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510743.4XP_006510806.1  C-myc promoter-binding protein isoform X1

      See identical proteins and their annotated locations for XP_006510806.1

      UniProtKB/TrEMBL
      E9Q8V6
      Conserved Domains (6) summary
      smart00801
      Location:560633
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:194276
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:811840
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:309493
      DENN; DENN (AEX-3) domain
      pfam10240
      Location:44207
      DUF2464; Multivesicular body subunit 12
      pfam13041
      Location:809849
      PPR_2; PPR repeat family
    2. XM_006510741.4XP_006510804.1  C-myc promoter-binding protein isoform X1

      See identical proteins and their annotated locations for XP_006510804.1

      UniProtKB/TrEMBL
      E9Q8V6
      Conserved Domains (6) summary
      smart00801
      Location:560633
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:194276
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:811840
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:309493
      DENN; DENN (AEX-3) domain
      pfam10240
      Location:44207
      DUF2464; Multivesicular body subunit 12
      pfam13041
      Location:809849
      PPR_2; PPR repeat family
    3. XM_006510745.4XP_006510808.1  C-myc promoter-binding protein isoform X1

      See identical proteins and their annotated locations for XP_006510808.1

      UniProtKB/TrEMBL
      E9Q8V6
      Conserved Domains (6) summary
      smart00801
      Location:560633
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:194276
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:811840
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:309493
      DENN; DENN (AEX-3) domain
      pfam10240
      Location:44207
      DUF2464; Multivesicular body subunit 12
      pfam13041
      Location:809849
      PPR_2; PPR repeat family
    4. XM_011242654.3XP_011240956.1  C-myc promoter-binding protein isoform X2

      Conserved Domains (6) summary
      smart00801
      Location:560633
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:194276
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:811840
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:309493
      DENN; DENN (AEX-3) domain
      pfam10240
      Location:44207
      DUF2464; Multivesicular body subunit 12
      pfam13041
      Location:809849
      PPR_2; PPR repeat family
    5. XM_030243936.2XP_030099796.1  C-myc promoter-binding protein isoform X1

      Related
      ENSMUSP00000037915.6, ENSMUST00000038890.6
      Conserved Domains (6) summary
      smart00801
      Location:560633
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:194276
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:811840
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:309493
      DENN; DENN (AEX-3) domain
      pfam10240
      Location:44207
      DUF2464; Multivesicular body subunit 12
      pfam13041
      Location:809849
      PPR_2; PPR repeat family
    6. XM_006510744.4XP_006510807.1  C-myc promoter-binding protein isoform X1

      See identical proteins and their annotated locations for XP_006510807.1

      UniProtKB/TrEMBL
      E9Q8V6
      Conserved Domains (6) summary
      smart00801
      Location:560633
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:194276
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:811840
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:309493
      DENN; DENN (AEX-3) domain
      pfam10240
      Location:44207
      DUF2464; Multivesicular body subunit 12
      pfam13041
      Location:809849
      PPR_2; PPR repeat family
    7. XM_030243937.2XP_030099797.1  C-myc promoter-binding protein isoform X1

      Conserved Domains (6) summary
      smart00801
      Location:560633
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:194276
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:811840
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:309493
      DENN; DENN (AEX-3) domain
      pfam10240
      Location:44207
      DUF2464; Multivesicular body subunit 12
      pfam13041
      Location:809849
      PPR_2; PPR repeat family
    8. XM_011242651.4XP_011240953.1  C-myc promoter-binding protein isoform X1

      See identical proteins and their annotated locations for XP_011240953.1

      UniProtKB/TrEMBL
      E9Q8V6
      Conserved Domains (6) summary
      smart00801
      Location:560633
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:194276
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:811840
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:309493
      DENN; DENN (AEX-3) domain
      pfam10240
      Location:44207
      DUF2464; Multivesicular body subunit 12
      pfam13041
      Location:809849
      PPR_2; PPR repeat family
    9. XM_030243938.2XP_030099798.1  C-myc promoter-binding protein isoform X1

      Conserved Domains (6) summary
      smart00801
      Location:560633
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:194276
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:811840
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:309493
      DENN; DENN (AEX-3) domain
      pfam10240
      Location:44207
      DUF2464; Multivesicular body subunit 12
      pfam13041
      Location:809849
      PPR_2; PPR repeat family
    10. XM_006510742.3XP_006510805.1  C-myc promoter-binding protein isoform X1

      See identical proteins and their annotated locations for XP_006510805.1

      UniProtKB/TrEMBL
      E9Q8V6
      Conserved Domains (6) summary
      smart00801
      Location:560633
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:194276
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:811840
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:309493
      DENN; DENN (AEX-3) domain
      pfam10240
      Location:44207
      DUF2464; Multivesicular body subunit 12
      pfam13041
      Location:809849
      PPR_2; PPR repeat family

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_176935.3: Suppressed sequence

      Description
      NM_176935.3: This RefSeq was temporarily suppressed because the CDS was partial.
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