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    Hinfp histone H4 transcription factor [ Mus musculus (house mouse) ]

    Gene ID: 102423, updated on 8-Feb-2024

    Summary

    Official Symbol
    Hinfpprovided by MGI
    Official Full Name
    histone H4 transcription factorprovided by MGI
    Primary source
    MGI:MGI:2429620
    See related
    Ensembl:ENSMUSG00000032119 AllianceGenome:MGI:2429620
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mizf; HiNF-P
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in in utero embryonic development; regulation of gene expression; and transcription, DNA-templated. Predicted to be located in Cajal body. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human HINFP (histone H4 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 5.6), CNS E14 (RPKM 5.0) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Hinfp in Genome Data Viewer
    Location:
    9 A5.2; 9 24.84 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44201509..44217003, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44292438..44305716, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene NLR family member X1 Neighboring gene ATP binding cassette subfamily G member 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44113766-44114058 Neighboring gene C2 calcium-dependent domain containing 2-like Neighboring gene STARR-seq mESC enhancer starr_23963 Neighboring gene dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 Neighboring gene H2A.X variant histone

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp434F162

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in anatomical structure development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell cycle G1/S phase transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in myoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    histone H4 transcription factor
    Names
    MBD2 (methyl-CpG-binding protein)-interacting zinc finger protein
    MBD2-interacting zinc finger protein
    histone nuclear factor P
    methyl-CpG-binding protein 2-interacting zinc finger protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001405064.1NP_001391993.1  histone H4 transcription factor

      Status: VALIDATED

      Source sequence(s)
      AC124577
      UniProtKB/Swiss-Prot
      E9QPQ4, Q8BWY0, Q8K1K9
      UniProtKB/TrEMBL
      Q4FK13
    2. NM_001405065.1NP_001391994.1  histone H4 transcription factor

      Status: VALIDATED

      Source sequence(s)
      AC124577
      UniProtKB/Swiss-Prot
      E9QPQ4, Q8BWY0, Q8K1K9
      UniProtKB/TrEMBL
      Q4FK13
      Related
      ENSMUSP00000034629.6, ENSMUST00000034629.6
    3. NM_001405066.1NP_001391995.1  histone H4 transcription factor

      Status: VALIDATED

      Source sequence(s)
      AC124577
      UniProtKB/Swiss-Prot
      E9QPQ4, Q8BWY0, Q8K1K9
      UniProtKB/TrEMBL
      Q4FK13
    4. NM_172162.4NP_751894.2  histone H4 transcription factor

      See identical proteins and their annotated locations for NP_751894.2

      Status: VALIDATED

      Source sequence(s)
      AC124577
      Consensus CDS
      CCDS23102.1
      UniProtKB/Swiss-Prot
      E9QPQ4, Q8BWY0, Q8K1K9
      UniProtKB/TrEMBL
      Q4FK13
      Related
      ENSMUSP00000149879.2, ENSMUST00000216508.2
      Conserved Domains (2) summary
      COG5048
      Location:224377
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:282302
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      44201509..44217003 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242379.3XP_011240681.1  histone H4 transcription factor isoform X2

      See identical proteins and their annotated locations for XP_011240681.1

      UniProtKB/TrEMBL
      Q4FK13
      Conserved Domains (2) summary
      COG5048
      Location:233386
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:291311
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. XM_011242378.4XP_011240680.1  histone H4 transcription factor isoform X2

      See identical proteins and their annotated locations for XP_011240680.1

      UniProtKB/TrEMBL
      Q4FK13
      Conserved Domains (2) summary
      COG5048
      Location:233386
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:291311
      ZF_C2H2; C2H2 Zn finger [structural motif]
    3. XM_006509897.5XP_006509960.1  histone H4 transcription factor isoform X3

      UniProtKB/TrEMBL
      Q4FK13
      Conserved Domains (2) summary
      COG5048
      Location:231384
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:289309
      ZF_C2H2; C2H2 Zn finger [structural motif]
    4. XM_030243934.2XP_030099794.1  histone H4 transcription factor isoform X2

      UniProtKB/TrEMBL
      Q4FK13
      Conserved Domains (2) summary
      COG5048
      Location:233386
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:291311
      ZF_C2H2; C2H2 Zn finger [structural motif]
    5. XM_011242376.4XP_011240678.1  histone H4 transcription factor isoform X1

      UniProtKB/TrEMBL
      Q4FK13
      Conserved Domains (2) summary
      COG5048
      Location:240393
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:298318
      ZF_C2H2; C2H2 Zn finger [structural motif]
    6. XM_036154502.1XP_036010395.1  histone H4 transcription factor isoform X2

      UniProtKB/TrEMBL
      Q4FK13
      Conserved Domains (2) summary
      COG5048
      Location:233386
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:291311
      ZF_C2H2; C2H2 Zn finger [structural motif]
    7. XM_030243935.2XP_030099795.1  histone H4 transcription factor isoform X4

      UniProtKB/Swiss-Prot
      E9QPQ4, Q8BWY0, Q8K1K9
      UniProtKB/TrEMBL
      Q4FK13
      Conserved Domains (2) summary
      COG5048
      Location:224377
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:282302
      ZF_C2H2; C2H2 Zn finger [structural motif]
    8. XM_030243933.2XP_030099793.1  histone H4 transcription factor isoform X2

      UniProtKB/TrEMBL
      Q4FK13
      Conserved Domains (2) summary
      COG5048
      Location:233386
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:291311
      ZF_C2H2; C2H2 Zn finger [structural motif]
    9. XM_011242377.4XP_011240679.1  histone H4 transcription factor isoform X2

      See identical proteins and their annotated locations for XP_011240679.1

      UniProtKB/TrEMBL
      Q4FK13
      Conserved Domains (2) summary
      COG5048
      Location:233386
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:291311
      ZF_C2H2; C2H2 Zn finger [structural motif]