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    Mtus1 mitochondrial tumor suppressor 1 [ Mus musculus (house mouse) ]

    Gene ID: 102103, updated on 26-Sep-2022

    Summary

    Official Symbol
    Mtus1provided by MGI
    Official Full Name
    mitochondrial tumor suppressor 1provided by MGI
    Primary source
    MGI:MGI:2142572
    See related
    Ensembl:ENSMUSG00000045636 AllianceGenome:MGI:2142572
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MD44; Atip1; MTSG1; ATBP135; mKIAA1288; Cctsg1-440; B430010I23Rik; B430305I03Rik
    Summary
    Predicted to enable microtubule binding activity. Acts upstream of or within regulation of macrophage chemotaxis. Located in cytoplasm. Is expressed in several structures, including extraembryonic component; eye; genitourinary system; heart; and nervous system. Orthologous to human MTUS1 (microtubule associated scaffold protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in heart adult (RPKM 15.8), cerebellum adult (RPKM 12.8) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mtus1 in Genome Data Viewer
    Location:
    8; 8 A4
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (41443949..41587347, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (40990912..41133983, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Neighboring gene platelet-derived growth factor receptor-like Neighboring gene RIKEN cDNA B430010I23 gene Neighboring gene predicted gene 16193 Neighboring gene predicted gene, 39167 Neighboring gene fibrinogen-like protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (2) 

    General gene information

    Markers

    Homology

    Clone Names

    • MGC115798

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of macrophage chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within regulation of macrophage chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    microtubule-associated tumor suppressor 1 homolog
    Names
    AT2 receptor-binding protein
    AT2 receptor-interacting protein 1
    angiotensin II AT2 receptor-interacting protein 1
    angiotensin-II type 2 receptor-interacting protein
    coiled-coiled tumor suppressor gene 1 protein
    coiled-coiled tumor supressor gene 1
    mitochondrial tumor suppressor 1 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005863.2NP_001005863.1  microtubule-associated tumor suppressor 1 homolog isoform 1

      See identical proteins and their annotated locations for NP_001005863.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AK143781, AW990620, BC089009
      Consensus CDS
      CCDS40328.1
      UniProtKB/Swiss-Prot
      Q5HZI1
      UniProtKB/TrEMBL
      A0A0R4J1L9
      Related
      ENSMUSP00000059503.7, ENSMUST00000059115.13
      Conserved Domains (1) summary
      TIGR02168
      Location:8551155
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    2. NM_001005864.3NP_001005864.1  microtubule-associated tumor suppressor 1 homolog isoform 3

      See identical proteins and their annotated locations for NP_001005864.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This results in shorter protein (isoform 3) with a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      BB647317, BC043321, DV650567
      Consensus CDS
      CCDS40329.1
      UniProtKB/Swiss-Prot
      Q5HZI1
      UniProtKB/TrEMBL
      A0A0R4J147
      Related
      ENSMUSP00000091252.5, ENSMUST00000093534.11
      Conserved Domains (2) summary
      pfam09755
      Location:193460
      DUF2046; Uncharacterized conserved protein H4 (DUF2046)
      cl19219
      Location:330406
      DUF342; Protein of unknown function (DUF342)
    3. NM_001005865.4NP_001005865.2  microtubule-associated tumor suppressor 1 homolog isoform 4

      See identical proteins and their annotated locations for NP_001005865.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This results in shorter protein (isoform 4) with a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC116511
      Consensus CDS
      CCDS40330.1
      UniProtKB/Swiss-Prot
      Q5HZI1
      UniProtKB/TrEMBL
      A0A0R4J0N9
      Related
      ENSMUSP00000053554.8, ENSMUST00000051379.14
      Conserved Domains (1) summary
      cl19219
      Location:250326
      DUF342; Protein of unknown function (DUF342)
    4. NM_001286413.2NP_001273342.1  microtubule-associated tumor suppressor 1 homolog isoform 1

      See identical proteins and their annotated locations for NP_001273342.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      AC116511, AC156554
      Consensus CDS
      CCDS40328.1
      UniProtKB/Swiss-Prot
      Q5HZI1
      UniProtKB/TrEMBL
      A0A0R4J1L9
      Related
      ENSMUSP00000112626.2, ENSMUST00000118835.8
      Conserved Domains (1) summary
      TIGR02168
      Location:8551155
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    5. NM_001403946.1NP_001390875.1  microtubule-associated tumor suppressor 1 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC116511, AC156554
      UniProtKB/TrEMBL
      A0A0R4J1L9
    6. NM_001403947.1NP_001390876.1  microtubule-associated tumor suppressor 1 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC116511, AC156554
      UniProtKB/TrEMBL
      A0A0R4J1L9
    7. NM_001403950.1NP_001390879.1  microtubule-associated tumor suppressor 1 homolog isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC116511, AC156554
    8. NM_001403952.1NP_001390881.1  microtubule-associated tumor suppressor 1 homolog isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC116511, AC156554
    9. NM_001403954.1NP_001390883.1  microtubule-associated tumor suppressor 1 homolog isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC116511
    10. NM_001403955.1NP_001390884.1  microtubule-associated tumor suppressor 1 homolog isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC116511
    11. NM_001403956.1NP_001390885.1  microtubule-associated tumor suppressor 1 homolog isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC116511, AC156554
      UniProtKB/TrEMBL
      Q8BXV7

    RNA

    1. NR_175785.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC116511, AC156554

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      41443949..41587347 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509240.5XP_006509303.1  microtubule-associated tumor suppressor 1 homolog isoform X1

      Conserved Domains (1) summary
      TIGR02168
      Location:8861205
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    2. XM_036153701.1XP_036009594.1  microtubule-associated tumor suppressor 1 homolog isoform X2

      Conserved Domains (1) summary
      TIGR02168
      Location:8551155
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    3. XM_006509239.3XP_006509302.1  microtubule-associated tumor suppressor 1 homolog isoform X1

      Conserved Domains (1) summary
      TIGR02168
      Location:8861205
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    4. XM_006509241.4XP_006509304.1  microtubule-associated tumor suppressor 1 homolog isoform X4

      Conserved Domains (1) summary
      TIGR02168
      Location:98417
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    5. XM_030243214.2XP_030099074.1  microtubule-associated tumor suppressor 1 homolog isoform X5

      Conserved Domains (1) summary
      TIGR02168
      Location:15291
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    6. XM_036153702.1XP_036009595.1  microtubule-associated tumor suppressor 1 homolog isoform X3

    RNA

    1. XR_004934740.1 RNA Sequence

    2. XR_004934738.1 RNA Sequence

    3. XR_004934737.1 RNA Sequence

    4. XR_004934739.1 RNA Sequence