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    NUTF2 nuclear transport factor 2 [ Homo sapiens (human) ]

    Gene ID: 10204, updated on 17-Jun-2024

    Summary

    Official Symbol
    NUTF2provided by HGNC
    Official Full Name
    nuclear transport factor 2provided by HGNC
    Primary source
    HGNC:HGNC:13722
    See related
    Ensembl:ENSG00000102898 MIM:605813; AllianceGenome:HGNC:13722
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NTF2; PP15; NTF-2
    Summary
    This gene encodes a cytosolic factor that facilitates protein transport into the nucleus. The encoded protein is required for nuclear import of the small Ras-like GTPase, Ran which is involved in numerous cellular processes. This protein also interacts with the nuclear pore complex glycoprotein p62. [provided by RefSeq, Apr 2016]
    Expression
    Ubiquitous expression in placenta (RPKM 14.8), testis (RPKM 14.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NUTF2 in Genome Data Viewer
    Location:
    16q22.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (67846933..67872567)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (73642707..73668340)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67880836..67906470)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:67840207-67840826 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7626 Neighboring gene translin associated factor X interacting protein 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:67851021-67851203 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67859393-67860253 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10987 Neighboring gene centromere protein T Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10988 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7627 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67876439-67877185 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10990 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7628 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7629 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10991 Neighboring gene THAP domain containing 11 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:67907171-67907671 Neighboring gene enhancer of mRNA decapping 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10992 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67918365-67918874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67918875-67919382 Neighboring gene neuritin 1 like

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog
    Common variants at 30 loci contribute to polygenic dyslipidemia.
    EBI GWAS Catalog
    Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    integrase gag-pol NTF2 is enriched at the nuclear envelope and interacts with NUP153, When added in excess to the import assay, NUP153C inhibited the nuclear import of IN. PubMed
    matrix gag NTF2 coordinates the activity of Ran by binding Ran-GDP into a complex with nucleoporin-docked karyopherins during nuclear import of HIV-1 Matrix PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of nuclear pore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein export from nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein localization to nuclear pore ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in nuclear inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of nuclear pore central transport channel IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    nuclear transport factor 2
    Names
    placental protein 15

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001322038.2NP_001308967.1  nuclear transport factor 2

      Status: REVIEWED

      Source sequence(s)
      AC040162
      Consensus CDS
      CCDS10848.1
      UniProtKB/Swiss-Prot
      B2R4G7, P13662, P61970, Q6IB67
      UniProtKB/TrEMBL
      H3BRV9
      Related
      ENSP00000515103.1, ENST00000700613.1
      Conserved Domains (1) summary
      cd00780
      Location:7122
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    2. NM_001322039.2NP_001308968.1  nuclear transport factor 2

      Status: REVIEWED

      Source sequence(s)
      AC040162, BP216441
      Consensus CDS
      CCDS10848.1
      UniProtKB/Swiss-Prot
      B2R4G7, P13662, P61970, Q6IB67
      UniProtKB/TrEMBL
      H3BRV9
      Related
      ENSP00000456428.1, ENST00000567105.5
      Conserved Domains (1) summary
      cd00780
      Location:7122
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    3. NM_001322040.2NP_001308969.1  nuclear transport factor 2

      Status: REVIEWED

      Source sequence(s)
      BX647782, HY123109, X07315
      Consensus CDS
      CCDS10848.1
      UniProtKB/Swiss-Prot
      B2R4G7, P13662, P61970, Q6IB67
      UniProtKB/TrEMBL
      H3BRV9
      Related
      ENSP00000457989.1, ENST00000569436.7
      Conserved Domains (1) summary
      cd00780
      Location:7122
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    4. NM_001322041.2NP_001308970.1  nuclear transport factor 2

      Status: REVIEWED

      Source sequence(s)
      AC040162, BX394845
      Consensus CDS
      CCDS10848.1
      UniProtKB/Swiss-Prot
      B2R4G7, P13662, P61970, Q6IB67
      UniProtKB/TrEMBL
      H3BRV9
      Related
      ENSP00000457022.1, ENST00000568396.2
      Conserved Domains (1) summary
      cd00780
      Location:7122
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    5. NM_005796.3NP_005787.1  nuclear transport factor 2

      See identical proteins and their annotated locations for NP_005787.1

      Status: REVIEWED

      Source sequence(s)
      BX647782, X07315
      Consensus CDS
      CCDS10848.1
      UniProtKB/Swiss-Prot
      B2R4G7, P13662, P61970, Q6IB67
      UniProtKB/TrEMBL
      H3BRV9
      Related
      ENSP00000219169.4, ENST00000219169.9
      Conserved Domains (1) summary
      cd00780
      Location:7122
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      67846933..67872567
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      73642707..73668340
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)