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    Rrp8 ribosomal RNA processing 8, methyltransferase, homolog (yeast) [ Mus musculus (house mouse) ]

    Gene ID: 101867, updated on 16-Feb-2019

    Summary

    Official Symbol
    Rrp8provided by MGI
    Official Full Name
    ribosomal RNA processing 8, methyltransferase, homolog (yeast)provided by MGI
    Primary source
    MGI:MGI:1914251
    See related
    Ensembl:ENSMUSG00000030888
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NML; AW538116; 1500003O22Rik; 2900001K19Rik
    Expression
    Ubiquitous expression in ovary adult (RPKM 12.5), bladder adult (RPKM 9.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Rrp8 in Genome Data Viewer
    Location:
    7; 7 E3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (105731730..105737385, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (112880723..112885014, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor interacting protein 2 Neighboring gene translocase of inner mitochondrial membrane 10B Neighboring gene dynein heavy chain domain 1 Neighboring gene mitochondrial ribosomal protein S36, pseudogene 2 Neighboring gene integrin linked kinase Neighboring gene TATA-box binding protein associated factor 10 Neighboring gene tripeptidyl peptidase I

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular response to glucose starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to glucose starvation ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin silencing at rDNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chromatin silencing at rDNA ISO
    Inferred from Sequence Orthology
    more info
     
    intrinsic apoptotic signaling pathway by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    methylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
     
    rRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription by glucose IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of transcription by glucose ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    chromatin silencing complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chromatin silencing complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    rDNA heterochromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    rDNA heterochromatin ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ribosomal RNA-processing protein 8
    Names
    cerebral protein 1 homolog
    nucleomethylin protein
    NP_080173.1
    NP_598712.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025897.2NP_080173.1  ribosomal RNA-processing protein 8 isoform 2

      See identical proteins and their annotated locations for NP_080173.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate exon in the 5' UTR and 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC121823, AK005138, AV460242
      Consensus CDS
      CCDS21658.1
      UniProtKB/Swiss-Prot
      Q9DB85
      Related
      ENSMUSP00000033179.6, ENSMUST00000033179.13
      Conserved Domains (1) summary
      pfam05148
      Location:243457
      Methyltransf_8; Hypothetical methyltransferase
    2. NM_133951.1NP_598712.1  ribosomal RNA-processing protein 8 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC121823
      Consensus CDS
      CCDS57576.1
      UniProtKB/TrEMBL
      E9PVA2
      Related
      ENSMUSP00000095752.4, ENSMUST00000098148.5
      Conserved Domains (1) summary
      pfam05148
      Location:289503
      Methyltransf_8; Hypothetical methyltransferase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      105731730..105737385 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_378204.2 RNA Sequence

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