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    RBM6 RNA binding motif protein 6 [ Homo sapiens (human) ]

    Gene ID: 10180, updated on 8-May-2017
    Official Symbol
    RBM6provided by HGNC
    Official Full Name
    RNA binding motif protein 6provided by HGNC
    Primary source
    HGNC:HGNC:9903
    See related
    Ensembl:ENSG00000004534 MIM:606886; Vega:OTTHUMG00000156736
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    3G2; g16; DEF3; DEF-3; HLC-11; NY-LU-12
    Orthologs
    Location:
    3p21.31
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 3 NC_000003.12 (49940038..50077252)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (49977474..50114685)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724438 Neighboring gene macrophage stimulating 1 receptor Neighboring gene MON1 homolog A, secretory trafficking associated Neighboring gene RBM5 antisense RNA 1 Neighboring gene RNA binding motif protein 5 Neighboring gene SEMA3F antisense RNA 1 Neighboring gene basic proline-rich protein-like Neighboring gene semaphorin 3F

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    NHGRI GWAS Catalog

    Description
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    NHGRI GWA Catalog
    Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ36517, FLJ39446, FLJ42036, DKFZp686B0877

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA processing TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    RNA-binding protein 6
    Names
    RNA-binding protein DEF-3
    lung cancer antigen NY-LU-12
    lung cancer protooncogene 11

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167582.1NP_001161054.1  RNA-binding protein 6 isoform 2

      See identical proteins and their annotated locations for NP_001161054.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several internal exons in the CDS, as compared to variant 1. This results in a downstream in-frame AUG start codon, and the resulting isoform (2) has a shorter N-terminus, as compared to isoform 1. Variants 2, 3, 4, 5, and 6 all encode the same isoform (2).
      Source sequence(s)
      AK291719, BC012112, BC046643
      Consensus CDS
      CCDS54586.1
      UniProtKB/Swiss-Prot
      P78332
      UniProtKB/TrEMBL
      A8K6Q4
      Related
      ENSP00000393530.1, OTTHUMP00000210492, ENST00000442092.5, OTTHUMT00000345533
      Conserved Domains (3) summary
      smart00443
      Location:527573
      G_patch; glycine rich nucleic binding domain
      cd12563
      Location:132218
      RRM2_RBM6; RNA recognition motif 2 in vertebrate RNA-binding protein 6 (RBM6)
      cd16163
      Location:244303
      OCRE_RBM6; OCRE domain found in RNA-binding protein 6 (RBM6) and similar proteins
    2. NM_001349190.1NP_001336119.1  RNA-binding protein 6 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variants 2, 4, 5, and 6, encodes isoform 2.
      Source sequence(s)
      AC104450, AC105935
    3. NM_001349191.1NP_001336120.1  RNA-binding protein 6 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variants 2, 3, 5, and 6, encodes isoform 2.
      Source sequence(s)
      AC104450, AC105935
    4. NM_001349192.1NP_001336121.1  RNA-binding protein 6 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 2, 3, 4, and 6, encodes isoform 2.
      Source sequence(s)
      AC104450, AC105935
    5. NM_001349193.1NP_001336122.1  RNA-binding protein 6 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 2, 3, 4, and 5, encodes isoform 2.
      Source sequence(s)
      AC104450, AC105935
    6. NM_001349194.1NP_001336123.1  RNA-binding protein 6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC104450, AC105935
    7. NM_005777.2NP_005768.1  RNA-binding protein 6 isoform 1

      See identical proteins and their annotated locations for NP_005768.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AF091264, AK291719, BC012112
      Consensus CDS
      CCDS2809.1
      UniProtKB/Swiss-Prot
      P78332
      UniProtKB/TrEMBL
      A8K6Q4
      Related
      ENSP00000266022.4, OTTHUMP00000210487, ENST00000266022.8, OTTHUMT00000345528
      Conserved Domains (5) summary
      smart00443
      Location:10491095
      G_patch; glycine rich nucleic binding domain
      COG1357
      Location:92237
      YjbI; Uncharacterized protein YjbI, contains pentapeptide repeats [Function unknown]
      cd12314
      Location:456533
      RRM1_RBM6; RNA recognition motif 1 in vertebrate RNA-binding protein 6 (RBM6)
      cd12563
      Location:654740
      RRM2_RBM6; RNA recognition motif 2 in vertebrate RNA-binding protein 6 (RBM6)
      cd16163
      Location:766825
      OCRE_RBM6; OCRE domain found in RNA-binding protein 6 (RBM6) and similar proteins

    RNA

    1. NR_146071.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC104450, AK291719, AK298108, BC012112

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p7 Primary Assembly

      Range
      49940038..50077252
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017005499.1XP_016860988.1  RNA-binding protein 6 isoform X6

      UniProtKB/Swiss-Prot
      P78332
      Conserved Domains (3) summary
      smart00443
      Location:527573
      G_patch; glycine rich nucleic binding domain
      cd12563
      Location:132218
      RRM2_RBM6; RNA recognition motif 2 in vertebrate RNA-binding protein 6 (RBM6)
      cd16163
      Location:244303
      OCRE_RBM6; OCRE domain found in RNA-binding protein 6 (RBM6) and similar proteins
    2. XM_017005501.1XP_016860990.1  RNA-binding protein 6 isoform X6

      UniProtKB/Swiss-Prot
      P78332
      Conserved Domains (3) summary
      smart00443
      Location:527573
      G_patch; glycine rich nucleic binding domain
      cd12563
      Location:132218
      RRM2_RBM6; RNA recognition motif 2 in vertebrate RNA-binding protein 6 (RBM6)
      cd16163
      Location:244303
      OCRE_RBM6; OCRE domain found in RNA-binding protein 6 (RBM6) and similar proteins
    3. XM_017005500.1XP_016860989.1  RNA-binding protein 6 isoform X6

      UniProtKB/Swiss-Prot
      P78332
      Conserved Domains (3) summary
      smart00443
      Location:527573
      G_patch; glycine rich nucleic binding domain
      cd12563
      Location:132218
      RRM2_RBM6; RNA recognition motif 2 in vertebrate RNA-binding protein 6 (RBM6)
      cd16163
      Location:244303
      OCRE_RBM6; OCRE domain found in RNA-binding protein 6 (RBM6) and similar proteins
    4. XM_005264784.1XP_005264841.1  RNA-binding protein 6 isoform X1

      See identical proteins and their annotated locations for XP_005264841.1

      UniProtKB/TrEMBL
      E9PGM9
      Related
      ENSP00000396466.1, OTTHUMP00000210501, ENST00000443081.5, OTTHUMT00000345553
      Conserved Domains (5) summary
      smart00443
      Location:917963
      G_patch; glycine rich nucleic binding domain
      COG1357
      Location:11127
      YjbI; Uncharacterized protein YjbI, contains pentapeptide repeats [Function unknown]
      cd12314
      Location:324401
      RRM1_RBM6; RNA recognition motif 1 in vertebrate RNA-binding protein 6 (RBM6)
      cd12563
      Location:522608
      RRM2_RBM6; RNA recognition motif 2 in vertebrate RNA-binding protein 6 (RBM6)
      cd16163
      Location:634693
      OCRE_RBM6; OCRE domain found in RNA-binding protein 6 (RBM6) and similar proteins
    5. XM_005264785.1XP_005264842.1  RNA-binding protein 6 isoform X3

      Conserved Domains (4) summary
      smart00443
      Location:568614
      G_patch; glycine rich nucleic binding domain
      cd12563
      Location:173259
      RRM2_RBM6; RNA recognition motif 2 in vertebrate RNA-binding protein 6 (RBM6)
      cd16163
      Location:285344
      OCRE_RBM6; OCRE domain found in RNA-binding protein 6 (RBM6) and similar proteins
      cl17169
      Location:152
      RRM_SF; RNA recognition motif (RRM) superfamily
    6. XM_006712916.1XP_006712979.1  RNA-binding protein 6 isoform X1

      See identical proteins and their annotated locations for XP_006712979.1

      UniProtKB/TrEMBL
      E9PGM9
      Conserved Domains (5) summary
      smart00443
      Location:917963
      G_patch; glycine rich nucleic binding domain
      COG1357
      Location:11127
      YjbI; Uncharacterized protein YjbI, contains pentapeptide repeats [Function unknown]
      cd12314
      Location:324401
      RRM1_RBM6; RNA recognition motif 1 in vertebrate RNA-binding protein 6 (RBM6)
      cd12563
      Location:522608
      RRM2_RBM6; RNA recognition motif 2 in vertebrate RNA-binding protein 6 (RBM6)
      cd16163
      Location:634693
      OCRE_RBM6; OCRE domain found in RNA-binding protein 6 (RBM6) and similar proteins
    7. XM_017005498.1XP_016860987.1  RNA-binding protein 6 isoform X5

    8. XM_005264786.1XP_005264843.1  RNA-binding protein 6 isoform X6

      UniProtKB/Swiss-Prot
      P78332
      Related
      ENSP00000392939.1, OTTHUMP00000210499, ENST00000422955.5, OTTHUMT00000345551
      Conserved Domains (3) summary
      smart00443
      Location:527573
      G_patch; glycine rich nucleic binding domain
      cd12563
      Location:132218
      RRM2_RBM6; RNA recognition motif 2 in vertebrate RNA-binding protein 6 (RBM6)
      cd16163
      Location:244303
      OCRE_RBM6; OCRE domain found in RNA-binding protein 6 (RBM6) and similar proteins
    9. XM_017005502.1XP_016860991.1  RNA-binding protein 6 isoform X6

      UniProtKB/Swiss-Prot
      P78332
      Conserved Domains (3) summary
      smart00443
      Location:527573
      G_patch; glycine rich nucleic binding domain
      cd12563
      Location:132218
      RRM2_RBM6; RNA recognition motif 2 in vertebrate RNA-binding protein 6 (RBM6)
      cd16163
      Location:244303
      OCRE_RBM6; OCRE domain found in RNA-binding protein 6 (RBM6) and similar proteins
    10. XM_005264787.2XP_005264844.1  RNA-binding protein 6 isoform X6

      UniProtKB/Swiss-Prot
      P78332
      Conserved Domains (3) summary
      smart00443
      Location:527573
      G_patch; glycine rich nucleic binding domain
      cd12563
      Location:132218
      RRM2_RBM6; RNA recognition motif 2 in vertebrate RNA-binding protein 6 (RBM6)
      cd16163
      Location:244303
      OCRE_RBM6; OCRE domain found in RNA-binding protein 6 (RBM6) and similar proteins
    11. XM_017005496.1XP_016860985.1  RNA-binding protein 6 isoform X2

      Related
      ENSP00000406548.1, OTTHUMP00000210489, ENST00000454079.5, OTTHUMT00000345530
    12. XM_017005497.1XP_016860986.1  RNA-binding protein 6 isoform X4

    RNA

    1. XR_001739976.1 RNA Sequence

    2. XR_001739975.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018914.2 Alternate CHM1_1.1

      Range
      49929564..50066750
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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