Format

Send to:

Choose Destination
    • Showing Current items.

    Psip1 PC4 and SFRS1 interacting protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 101739, updated on 28-Jun-2021

    Summary

    Official Symbol
    Psip1provided by MGI
    Official Full Name
    PC4 and SFRS1 interacting protein 1provided by MGI
    Primary source
    MGI:MGI:2142116
    See related
    Ensembl:ENSMUSG00000028484
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P; Dfs70; Psip2; Ledgfa; Ledgfb; AA408851; AU015605
    Expression
    Broad expression in CNS E11.5 (RPKM 73.8), CNS E14 (RPKM 48.3) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Psip1 in Genome Data Viewer
    Location:
    4; 4 C3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (83373917..83404700, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (83455680..83486463, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (83101584..83132294, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42306 Neighboring gene predicted gene 11413 Neighboring gene predicted gene 11184 Neighboring gene small nuclear RNA activating complex, polypeptide 3 Neighboring gene ribosomal protein L34 pseudogene Neighboring gene predicted gene, 42308

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables supercoiled DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in heterochromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear periphery ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in transcriptionally active chromatin ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    PC4 and SFRS1-interacting protein
    Names
    PC4 and SFRS1 interacting protein 2
    dense fine speckles 70
    lens epithelium-derived growth factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290527.2NP_001277456.1  PC4 and SFRS1-interacting protein isoform 2

      See identical proteins and their annotated locations for NP_001277456.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 3' exon structure, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AA177775, AI839843, AI843830, BC043079, BX682545, BY710824, CJ053610
      Consensus CDS
      CCDS71412.1
      UniProtKB/Swiss-Prot
      Q99JF8
      Related
      ENSMUSP00000102833.3, ENSMUST00000107215.9
      Conserved Domains (1) summary
      cd05834
      Location:387
      HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...
    2. NM_001347143.2NP_001334072.1  PC4 and SFRS1-interacting protein isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AA177775, BG076985, BM945511, BP766700, BX682545, CA328141, CK626008
      Consensus CDS
      CCDS84749.1
      UniProtKB/TrEMBL
      A2BI12
      Related
      ENSMUSP00000102832.3, ENSMUST00000107214.9
    3. NM_001355203.1NP_001342132.1  PC4 and SFRS1-interacting protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AA177775, AI843830, BC043079, BX682545, BY710824, CD352945, CJ053610
      Conserved Domains (2) summary
      cd05834
      Location:387
      HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...
      cl26407
      Location:95245
      IF-2; Translation-initiation factor 2
    4. NM_133948.6NP_598709.1  PC4 and SFRS1-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_598709.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      BC043079, BX682545, BY710824, CJ053610
      Consensus CDS
      CCDS18299.1
      UniProtKB/Swiss-Prot
      Q99JF8
      Related
      ENSMUSP00000030207.9, ENSMUST00000030207.15
      Conserved Domains (2) summary
      cd05834
      Location:387
      HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...
      pfam11467
      Location:347448
      LEDGF; Lens epithelium-derived growth factor (LEDGF)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      83373917..83404700 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center