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    Grwd1 glutamate-rich WD repeat containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 101612, updated on 31-Jan-2019

    Summary

    Official Symbol
    Grwd1provided by MGI
    Official Full Name
    glutamate-rich WD repeat containing 1provided by MGI
    Primary source
    MGI:MGI:2141989
    See related
    Ensembl:ENSMUSG00000053801
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A301; Grwd; Wdr28; AI504353
    Expression
    Ubiquitous expression in ovary adult (RPKM 12.6), limb E14.5 (RPKM 9.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Grwd1 in Genome Data Viewer
    Location:
    7; 7 B3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (45825223..45830994, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (53080593..53086159, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene lemur tyrosine kinase 3 Neighboring gene cytohesin 2 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 14 Neighboring gene glutamate receptor, ionotropic, NMDA2D (epsilon 4) Neighboring gene KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA replication origin binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    nucleosome disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    glutamate-rich WD repeat-containing protein 1
    Names
    glutamate rich WD repeat protein GRWD

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153419.2NP_700468.2  glutamate-rich WD repeat-containing protein 1

      See identical proteins and their annotated locations for NP_700468.2

      Status: VALIDATED

      Source sequence(s)
      BC083143, BQ886252, DT904438
      Consensus CDS
      CCDS21266.2
      UniProtKB/Swiss-Prot
      Q810D6
      UniProtKB/TrEMBL
      Q5XJZ3
      Related
      ENSMUSP00000103351.2, ENSMUST00000107723.8
      Conserved Domains (4) summary
      COG2319
      Location:194383
      WD40; WD40 repeat [General function prediction only]
      pfam12265
      Location:44111
      CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex
      sd00039
      Location:218259
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:206384
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. NR_152183.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC149053

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      45825223..45830994 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540540.3XP_006540603.1  glutamate-rich WD repeat-containing protein 1 isoform X2

      Conserved Domains (3) summary
      COG2319
      Location:91280
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:115156
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:103281
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_017321912.1XP_017177401.1  glutamate-rich WD repeat-containing protein 1 isoform X1

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