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    Grwd1 glutamate-rich WD repeat containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 101612, updated on 23-Jun-2021

    Summary

    Official Symbol
    Grwd1provided by MGI
    Official Full Name
    glutamate-rich WD repeat containing 1provided by MGI
    Primary source
    MGI:MGI:2141989
    See related
    Ensembl:ENSMUSG00000053801
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A301; Grwd; WDR2; Wdr28; AI504353
    Expression
    Ubiquitous expression in ovary adult (RPKM 12.6), limb E14.5 (RPKM 9.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Grwd1 in Genome Data Viewer
    Location:
    7; 7 B3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45474647..45480418, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45825223..45830994, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (53080593..53086159, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene lemur tyrosine kinase 3 Neighboring gene cytohesin 2 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 14 Neighboring gene predicted gene 45441 Neighboring gene glutamate receptor, ionotropic, NMDA2D (epsilon 4) Neighboring gene KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA replication origin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleosome disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    glutamate-rich WD repeat-containing protein 1
    Names
    glutamate rich WD repeat protein GRWD

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153419.2NP_700468.2  glutamate-rich WD repeat-containing protein 1

      See identical proteins and their annotated locations for NP_700468.2

      Status: VALIDATED

      Source sequence(s)
      BC083143, BQ886252, DT904438
      Consensus CDS
      CCDS21266.2
      UniProtKB/Swiss-Prot
      Q810D6
      UniProtKB/TrEMBL
      Q5XJZ3
      Related
      ENSMUSP00000103351.3, ENSMUST00000107723.9
      Conserved Domains (4) summary
      COG2319
      Location:194383
      WD40; WD40 repeat [General function prediction only]
      pfam12265
      Location:44111
      CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex
      sd00039
      Location:218259
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:206384
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. NR_152183.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC149053
      Related
      ENSMUST00000209484.2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      45474647..45480418 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321912.3XP_017177401.1  glutamate-rich WD repeat-containing protein 1 isoform X1

      Conserved Domains (3) summary
      sd00039
      Location:175212
      7WD40; WD40 repeat [structural motif]
      pfam12265
      Location:44112
      CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex
      cl29593
      Location:205354
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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