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    TRIM28 tripartite motif containing 28 [ Homo sapiens (human) ]

    Gene ID: 10155, updated on 8-Jul-2021

    Summary

    Official Symbol
    TRIM28provided by HGNC
    Official Full Name
    tripartite motif containing 28provided by HGNC
    Primary source
    HGNC:HGNC:16384
    See related
    Ensembl:ENSG00000130726 MIM:601742
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KAP1; TF1B; RNF96; TIF1B; PPP1R157
    Summary
    The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in ovary (RPKM 89.1), testis (RPKM 80.5) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See TRIM28 in Genome Data Viewer
    Location:
    19q13.43
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (58544064..58550722)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (59055431..59062082)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372486 Neighboring gene zinc finger and BTB domain containing 45 Neighboring gene RNA, 7SL, cytoplasmic 525, pseudogene Neighboring gene microRNA 6807 Neighboring gene charged multivesicular body protein 2A Neighboring gene ubiquitin conjugating enzyme E2 M

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify tripartite motif containing 28 (TRIM28), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify tripartite motif containing 28 (TRIM28), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify tripartite motif containing 28 (TRIM28), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify tripartite motif containing 28 (TRIM28), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    integrase gag-pol KAP1 inhibits HIV-1 integration via HIV-1 IN acetylation-dependent mechanism through HDAC1 PubMed
    gag-pol The interaction between HIV-1 IN and KAP1 is highly favored by HAT/p300-mediated IN acetylation PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ29029

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables Krueppel-associated box domain binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding HDA PubMed 
    enables SUMO transferase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromo shadow domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables promoter-specific chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA methylation involved in embryo development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in Ras protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in convergent extension involved in axis elongation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryo implantation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic placenta morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epithelial to mesenchymal transition ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in innate immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of DNA demethylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of viral release from host cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA methylation-dependent heterochromatin assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA methylation-dependent heterochromatin assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of DNA repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein sumoylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of genetic imprinting IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of RNA polymerase II transcription regulator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in euchromatin IEA
    Inferred from Electronic Annotation
    more info
     
    located_in heterochromatin IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    transcription intermediary factor 1-beta
    Names
    E3 SUMO-protein ligase TRIM28
    KAP-1
    KRAB [Kruppel-associated box domain]-associated protein 1
    KRAB-interacting protein 1
    KRIP-1
    RING finger protein 96
    RING-type E3 ubiquitin transferase TIF1-beta
    TIF1-beta
    nuclear corepressor KAP-1
    protein phosphatase 1, regulatory subunit 157
    transcriptional intermediary factor 1-beta
    NP_005753.1
    XP_024307077.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046945.1 RefSeqGene

      Range
      4596..11247
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005762.3NP_005753.1  transcription intermediary factor 1-beta

      See identical proteins and their annotated locations for NP_005753.1

      Status: REVIEWED

      Source sequence(s)
      AC016630, BC004978
      Consensus CDS
      CCDS12985.1
      UniProtKB/Swiss-Prot
      Q13263
      Related
      ENSP00000253024.4, ENST00000253024.10
      Conserved Domains (7) summary
      cd05502
      Location:696802
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00502
      Location:252378
      BBC; B-Box C-terminal domain
      cd15623
      Location:627669
      PHD_TIF1beta; PHD finger found in transcription intermediary factor 1-beta (TIF1-beta)
      cd16765
      Location:62124
      RING-HC_TIF1beta; RING finger, HC subclass, found in transcription inknown asiary factor 1-beta (TIF1-beta)
      cd19829
      Location:206249
      Bbox2_TIF1b_C-VI; B-box-type 2 zinc finger found in transcription intermediary factor 1-beta (TIF1-beta)
      cd19846
      Location:148199
      Bbox1_TIF1b_C-VI; B-box-type 1 zinc finger found in transcription intermediary factor 1-beta (TIF1-beta)
      NF033761
      Location:526626
      gliding_GltJ; adventurous gliding motility protein GltJ

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      58544064..58550722
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024451309.1XP_024307077.1  transcription intermediary factor 1-beta isoform X1

      Conserved Domains (7) summary
      smart00502
      Location:252378
      BBC; B-Box C-terminal domain
      smart00336
      Location:148184
      BBOX; B-Box-type zinc finger
      cd00021
      Location:207245
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      cd15623
      Location:627669
      PHD_TIF1beta; PHD finger found in transcription intermediary factor 1-beta (TIF1-beta)
      cd16765
      Location:62124
      RING-HC_TIF1beta; RING finger, HC subclass, found in transcription inknown asiary factor 1-beta (TIF1-beta)
      cl02556
      Location:696839
      Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
      cl25756
      Location:525620
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
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