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    Plekha1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 [ Mus musculus (house mouse) ]

    Gene ID: 101476, updated on 12-Aug-2018

    Summary

    Official Symbol
    Plekha1provided by MGI
    Official Full Name
    pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1provided by MGI
    Primary source
    MGI:MGI:2442213
    See related
    Ensembl:ENSMUSG00000040268 Vega:OTTMUSG00000029137
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TAPP1; AA960558; C920009D07Rik
    Expression
    Broad expression in CNS E18 (RPKM 32.7), whole brain E14.5 (RPKM 25.8) and 26 other tissues See more
    Orthologs

    Genomic context

    See Plekha1 in Genome Data Viewer
    Location:
    7; 7 F3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (130860556..130913308)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (138009424..138056816)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene transforming, acidic coiled-coil containing protein 2 Neighboring gene predicted gene, 34283 Neighboring gene histone H2A.Z-like Neighboring gene BTB (POZ) domain containing 16 Neighboring gene predicted gene 5602 Neighboring gene microRNA 7061 Neighboring gene HtrA serine peptidase 1 Neighboring gene deleted in malignant brain tumors 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    PDZ domain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol-3,4-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Leydig cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    androgen metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    estrogen metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    face morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    female gonad development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    luteinization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
     
    platelet-derived growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    roof of mouth development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ruffle organization ISO
    Inferred from Sequence Orthology
    more info
     
    skeletal system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    pleckstrin homology domain-containing family A member 1
    Names
    PH domain-containing family A member 1
    TAPP-1
    tandem PH domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346515.1NP_001333444.1  pleckstrin homology domain-containing family A member 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC115697
      Consensus CDS
      CCDS85434.1
      UniProtKB/Swiss-Prot
      Q8BUL6
    2. NM_001357696.1NP_001344625.1  pleckstrin homology domain-containing family A member 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC115697
      Conserved Domains (2) summary
      cd13270
      Location:1117
      PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
      cd13271
      Location:185296
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    3. NM_133942.3NP_598703.1  pleckstrin homology domain-containing family A member 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC115697
      Consensus CDS
      CCDS21907.1
      UniProtKB/Swiss-Prot
      Q8BUL6
      Related
      ENSMUSP00000035375.5, OTTMUSP00000037145, ENSMUST00000048180.11
      Conserved Domains (3) summary
      cd13271
      Location:137250
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
      pfam00169
      Location:144240
      PH; PH domain
      cl17171
      Location:175
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      130860556..130913308
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321904.1XP_017177393.1  pleckstrin homology domain-containing family A member 1 isoform X1

      Conserved Domains (3) summary
      cd13270
      Location:1117
      PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
      cd13271
      Location:185296
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
      pfam00169
      Location:192288
      PH; PH domain
    2. XM_006507140.1XP_006507203.1  pleckstrin homology domain-containing family A member 1 isoform X1

      Conserved Domains (3) summary
      cd13270
      Location:1117
      PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
      cd13271
      Location:185296
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
      pfam00169
      Location:192288
      PH; PH domain
    3. XM_006507146.1XP_006507209.1  pleckstrin homology domain-containing family A member 1 isoform X3

      Conserved Domains (2) summary
      cd13270
      Location:1117
      PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
      cd13271
      Location:185296
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    4. XM_006507153.2XP_006507216.1  pleckstrin homology domain-containing family A member 1 isoform X8

      UniProtKB/TrEMBL
      D3YU01
      Related
      ENSMUSP00000112777.1, OTTMUSP00000037144, ENSMUST00000120441.7, OTTMUST00000072264
      Conserved Domains (3) summary
      cd13270
      Location:1117
      PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
      cd13271
      Location:185298
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
      pfam00169
      Location:192288
      PH; PH domain
    5. XM_006507147.1XP_006507210.1  pleckstrin homology domain-containing family A member 1 isoform X4

      Conserved Domains (3) summary
      cd13270
      Location:1117
      PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
      cd13271
      Location:185298
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
      pfam00169
      Location:192288
      PH; PH domain
    6. XM_006507148.1XP_006507211.1  pleckstrin homology domain-containing family A member 1 isoform X5

      Conserved Domains (3) summary
      cd13270
      Location:1117
      PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
      cd13271
      Location:185298
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
      pfam00169
      Location:192288
      PH; PH domain
    7. XM_006507145.1XP_006507208.1  pleckstrin homology domain-containing family A member 1 isoform X2

      Conserved Domains (3) summary
      cd13270
      Location:1117
      PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
      cd13271
      Location:185298
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
      pfam00169
      Location:192288
      PH; PH domain
    8. XM_006507150.1XP_006507213.1  pleckstrin homology domain-containing family A member 1 isoform X6

      Conserved Domains (3) summary
      cd13271
      Location:137248
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
      pfam00169
      Location:144240
      PH; PH domain
      cl17171
      Location:175
      PH-like; Pleckstrin homology-like domain
    9. XM_006507152.1XP_006507215.1  pleckstrin homology domain-containing family A member 1 isoform X7

      Related
      ENSMUSP00000123600.2, OTTMUSP00000037146, ENSMUST00000151119.8, OTTMUST00000072266
      Conserved Domains (3) summary
      cd13270
      Location:1117
      PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
      cd13271
      Location:185296
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
      pfam00169
      Location:192288
      PH; PH domain
    10. XM_006507151.3XP_006507214.1  pleckstrin homology domain-containing family A member 1 isoform X6

      Conserved Domains (3) summary
      cd13271
      Location:137248
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
      pfam00169
      Location:144240
      PH; PH domain
      cl17171
      Location:175
      PH-like; Pleckstrin homology-like domain
    11. XM_006507141.3XP_006507204.1  pleckstrin homology domain-containing family A member 1 isoform X1

      Conserved Domains (3) summary
      cd13270
      Location:1117
      PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
      cd13271
      Location:185296
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
      pfam00169
      Location:192288
      PH; PH domain
    12. XM_006507149.3XP_006507212.1  pleckstrin homology domain-containing family A member 1 isoform X5

      UniProtKB/Swiss-Prot
      Q8BUL6
      Related
      ENSMUSP00000074675.4, OTTMUSP00000037143, ENSMUST00000075181.10, OTTMUST00000072263
      Conserved Domains (3) summary
      cd13270
      Location:1117
      PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
      cd13271
      Location:185298
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
      pfam00169
      Location:192288
      PH; PH domain
    13. XM_006507143.3XP_006507206.1  pleckstrin homology domain-containing family A member 1 isoform X1

      Conserved Domains (3) summary
      cd13270
      Location:1117
      PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
      cd13271
      Location:185296
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
      pfam00169
      Location:192288
      PH; PH domain
    14. XM_006507142.3XP_006507205.1  pleckstrin homology domain-containing family A member 1 isoform X1

      Conserved Domains (3) summary
      cd13270
      Location:1117
      PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
      cd13271
      Location:185296
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
      pfam00169
      Location:192288
      PH; PH domain
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