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    Dhx32 DEAH (Asp-Glu-Ala-His) box polypeptide 32 [ Mus musculus (house mouse) ]

    Gene ID: 101437, updated on 17-Jul-2021

    Summary

    Official Symbol
    Dhx32provided by MGI
    Official Full Name
    DEAH (Asp-Glu-Ala-His) box polypeptide 32provided by MGI
    Primary source
    MGI:MGI:2141813
    See related
    Ensembl:ENSMUSG00000030986
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ddx32; muDDX32; AA408140; 3110079L04Rik; 4732469F02Rik
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 23.6), placenta adult (RPKM 18.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Dhx32 in Genome Data Viewer
    Location:
    7; 7 F3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (133322662..133384514, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (133720935..133782785, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (140912618..140968486, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 21 Neighboring gene uroporphyrinogen III synthase Neighboring gene BRCA2 and CDKN1A interacting protein Neighboring gene predicted gene 15483 Neighboring gene fibronectin type 3 and ankyrin repeat domains 1 Neighboring gene a disintegrin and metallopeptidase domain 12 (meltrin alpha) Neighboring gene predicted gene, 51500 Neighboring gene predicted gene, 39103

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in intracellular anatomical structure IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32
    Names
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 32
    DEAH box protein 32
    helicase DDX32
    NP_001272959.1
    NP_001272960.1
    NP_001272961.1
    NP_001344614.1
    NP_598702.1
    XP_006507200.1
    XP_006507201.1
    XP_036008401.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286030.1NP_001272959.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform a

      See identical proteins and their annotated locations for NP_001272959.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, and 3 all encode isoform a.
      Source sequence(s)
      AK135760, AK169005, AY065980
      Consensus CDS
      CCDS21936.1
      UniProtKB/Swiss-Prot
      Q8BZS9
      Related
      ENSMUST00000140593.9
      Conserved Domains (1) summary
      COG1643
      Location:19687
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    2. NM_001286031.1NP_001272960.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform a

      See identical proteins and their annotated locations for NP_001272960.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AK028910, AK169005, AY065980, BY070275
      Consensus CDS
      CCDS21936.1
      UniProtKB/Swiss-Prot
      Q8BZS9
      Related
      ENSMUSP00000066067.2, ENSMUST00000063669.8
      Conserved Domains (1) summary
      COG1643
      Location:19687
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    3. NM_001286032.1NP_001272961.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform b

      See identical proteins and their annotated locations for NP_001272961.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks the exon containing the translation start codon and therefore uses a downstream start codon compared to variant 1. It encodes isoform b, which has a shorter N-terminus compared to isoform a.
      Source sequence(s)
      AK033624, AK079184, AK169005, AY065980
      Consensus CDS
      CCDS72060.1
      UniProtKB/Swiss-Prot
      Q8BZS9
      UniProtKB/TrEMBL
      D3Z4E3
      Related
      ENSMUSP00000101745.2, ENSMUST00000106139.8
      Conserved Domains (3) summary
      smart00847
      Location:332416
      HA2; Helicase associated domain (HA2) Add an annotation
      COG1643
      Location:1547
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      pfam07717
      Location:457564
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    4. NM_001357685.1NP_001344614.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform c, which is shorter when compared to isoform a.
      Source sequence(s)
      AC127348
      Conserved Domains (1) summary
      COG1643
      Location:19672
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    5. NM_133941.2NP_598702.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform a

      See identical proteins and their annotated locations for NP_598702.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AK033624, AK169005
      Consensus CDS
      CCDS21936.1
      UniProtKB/Swiss-Prot
      Q8BZS9
      Related
      ENSMUSP00000033290.6, ENSMUST00000033290.12
      Conserved Domains (1) summary
      COG1643
      Location:19687
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      133322662..133384514 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152508.1XP_036008401.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform X2

      Conserved Domains (1) summary
      COG1643
      Location:19672
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    2. XM_006507137.2XP_006507200.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform X1

      See identical proteins and their annotated locations for XP_006507200.1

      UniProtKB/Swiss-Prot
      Q8BZS9
      Conserved Domains (1) summary
      COG1643
      Location:19687
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    3. XM_006507138.2XP_006507201.1  putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform X1

      See identical proteins and their annotated locations for XP_006507201.1

      UniProtKB/Swiss-Prot
      Q8BZS9
      Conserved Domains (1) summary
      COG1643
      Location:19687
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
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