U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    SGK2 serum/glucocorticoid regulated kinase 2 [ Homo sapiens (human) ]

    Gene ID: 10110, updated on 10-Dec-2024

    Summary

    Official Symbol
    SGK2provided by HGNC
    Official Full Name
    serum/glucocorticoid regulated kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:13900
    See related
    Ensembl:ENSG00000101049 MIM:607589; AllianceGenome:HGNC:13900
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    H-SGK2; dJ138B7.2
    Summary
    This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
    Expression
    Biased expression in kidney (RPKM 17.8), colon (RPKM 13.6) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SGK2 in Genome Data Viewer
    Location:
    20q13.12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (43559027..43585627)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (45292229..45318829)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (42187667..42214267)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1251, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12926 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12927 Neighboring gene L3MBTL histone methyl-lysine binding protein 1 Neighboring gene transmembrane protein 14C-like Neighboring gene ReSE screen-validated silencer GRCh37_chr20:42173308-42173524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17904 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:42236005-42236846 Neighboring gene intraflagellar transport 52 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:42266543-42266756 Neighboring gene ribosomal protein L27a pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables potassium channel regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables sodium channel regulator activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables sodium channel regulator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase Sgk2
    Names
    SGK2, serine/threonine kinase 2
    NP_001186193.1
    NP_057360.3
    NP_733794.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029448.2 RefSeqGene

      Range
      5033..31633
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1050

    mRNA and Protein(s)

    1. NM_001199264.2NP_001186193.1  serine/threonine-protein kinase Sgk2

      See identical proteins and their annotated locations for NP_001186193.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate in-frame exon in the 5' coding region, compared to variant 2. Variants 1, 2 and 3 all encode the same protein.
      Source sequence(s)
      BC065511, DA244897
      Consensus CDS
      CCDS13321.1
      UniProtKB/Swiss-Prot
      Q52PK5, Q5H8Y6, Q5H8Z1, Q5TZR3, Q9HBY8, Q9UKG6
      UniProtKB/TrEMBL
      A8K0N1
      Related
      ENSP00000392795.3, ENST00000423407.7
      Conserved Domains (1) summary
      cd05603
      Location:39359
      STKc_SGK2; Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 2
    2. NM_016276.5NP_057360.3  serine/threonine-protein kinase Sgk2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes the longest transcript. Variants 1, 2 and 3 all encode the same protein.
      Source sequence(s)
      AF186470, BC065511, CD627734, Z98752
      Consensus CDS
      CCDS13321.1
      UniProtKB/Swiss-Prot
      Q52PK5, Q5H8Y6, Q5H8Z1, Q5TZR3, Q9HBY8, Q9UKG6
      UniProtKB/TrEMBL
      A8K0N1
      Related
      ENSP00000340608.5, ENST00000341458.10
      Conserved Domains (1) summary
      cd05603
      Location:39359
      STKc_SGK2; Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 2
    3. NM_170693.3NP_733794.1  serine/threonine-protein kinase Sgk2

      See identical proteins and their annotated locations for NP_733794.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) contains an alternate in-frame exon in the 5' coding region, compared to variant 2. Variants 1, 2 and 3 all encode the same protein.
      Source sequence(s)
      AF169034, BC065511, DB183229
      Consensus CDS
      CCDS13321.1
      UniProtKB/Swiss-Prot
      Q52PK5, Q5H8Y6, Q5H8Z1, Q5TZR3, Q9HBY8, Q9UKG6
      UniProtKB/TrEMBL
      A8K0N1
      Related
      ENSP00000362192.1, ENST00000373100.7
      Conserved Domains (1) summary
      cd05603
      Location:39359
      STKc_SGK2; Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      43559027..43585627
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      45292229..45318829
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)