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    Nfxl1 nuclear transcription factor, X-box binding-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 100978, updated on 12-Aug-2018

    Summary

    Official Symbol
    Nfxl1provided by MGI
    Official Full Name
    nuclear transcription factor, X-box binding-like 1provided by MGI
    Primary source
    MGI:MGI:1923646
    See related
    Ensembl:ENSMUSG00000072889 Vega:OTTMUSG00000026056
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GCF; TCF9; DNABF; Gm1058; AW538212; 1700012H24Rik; D430033A06Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 9.0), limb E14.5 (RPKM 7.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Nfxl1 in Genome Data Viewer
    Location:
    5; 5 C3.2
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (72513301..72559713, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (72904543..72950884, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene ATPase, class V, type 10D Neighboring gene corin Neighboring gene synaptonemal complex central element protein 2 pseudogene Neighboring gene uncharacterized LOC108169048 Neighboring gene zygote arrest 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    NF-X1-type zinc finger protein NFXL1
    Names
    ovarian zinc finger protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359837.1NP_001346766.1  NF-X1-type zinc finger protein NFXL1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC161529
      Conserved Domains (1) summary
      cd16697
      Location:165222
      RING-CH-C4HC3_NFXL1; RING-CH finger, H2 subclass (C4HC3-type), found in nuclear transcription factor, X-box binding-like 1 (NFXL1) and similar proteins
    2. NM_133921.3NP_598682.2  NF-X1-type zinc finger protein NFXL1 isoform 1

      See identical proteins and their annotated locations for NP_598682.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC161529
      Consensus CDS
      CCDS39109.1
      UniProtKB/TrEMBL
      E9Q8I7
      Related
      ENSMUSP00000084467.5, OTTMUSP00000031920, ENSMUST00000087216.11
      Conserved Domains (1) summary
      cd06008
      Location:421469
      NF-X1-zinc-finger; Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger ...

    RNA

    1. NR_153351.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate coding exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC161529, AK132320

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      72513301..72559713 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240686.1XP_011238988.1  NF-X1-type zinc finger protein NFXL1 isoform X1

      See identical proteins and their annotated locations for XP_011238988.1

      UniProtKB/TrEMBL
      E9Q8I7
      Conserved Domains (1) summary
      cd06008
      Location:421469
      NF-X1-zinc-finger; Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger ...

    RNA

    1. XR_376794.3 RNA Sequence

      Related
      ENSMUST00000135318.7, OTTMUST00000064324
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