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    HHLA1 HHLA1 neighbor of OC90 [ Homo sapiens (human) ]

    Gene ID: 10086, updated on 5-Mar-2024

    Summary

    Official Symbol
    HHLA1provided by HGNC
    Official Full Name
    HHLA1 neighbor of OC90provided by HGNC
    Primary source
    HGNC:HGNC:4904
    See related
    Ensembl:ENSG00000132297 MIM:604109; AllianceGenome:HGNC:4904
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PLA2L
    Summary
    Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See HHLA1 in Genome Data Viewer
    Location:
    8q24.22
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (132061480..132111157, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (133184384..133234063, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (133073727..133123404, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27991 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19557 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr8:132964728-132965406 Neighboring gene EFR3 homolog A Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:133036851-133038050 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:133057119-133057670 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:133066195-133066695 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:133070122-133070699 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:133070700-133071276 Neighboring gene Sharpr-MPRA regulatory region 9765 Neighboring gene otoconin 90 Neighboring gene Sharpr-MPRA regulatory region 9796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:133141080-133141580 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:133141581-133142081 Neighboring gene potassium voltage-gated channel subfamily Q member 3 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:133358485-133359684 Neighboring gene NANOG hESC enhancer GRCh37_chr8:133405895-133406396 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:133406347-133406528 Neighboring gene VISTA enhancer hs2563 Neighboring gene uncharacterized LOC105375765

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    HERV-H LTR-associating protein 1
    Names
    HERV-H LTR-associating 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145095.3NP_001138567.1  HERV-H LTR-associating protein 1 precursor

      See identical proteins and their annotated locations for NP_001138567.1

      Status: VALIDATED

      Source sequence(s)
      AC100868, AC131042
      UniProtKB/Swiss-Prot
      C9JL84
      UniProtKB/TrEMBL
      A0A5F9ZHM0
      Related
      ENSP00000388322.1, ENST00000414222.2
      Conserved Domains (1) summary
      PHA03247
      Location:218443
      PHA03247; large tegument protein UL36; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      132061480..132111157 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      133184384..133234063 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_005712.1: Suppressed sequence

      Description
      NM_005712.1: This RefSeq was permanently suppressed because it was based on a sequence that is found only in tumorigenic tissues and cells.