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    Tbc1d14 TBC1 domain family, member 14 [ Mus musculus (house mouse) ]

    Gene ID: 100855, updated on 23-Jun-2021

    Summary

    Official Symbol
    Tbc1d14provided by MGI
    Official Full Name
    TBC1 domain family, member 14provided by MGI
    Primary source
    MGI:MGI:1098708
    See related
    Ensembl:ENSMUSG00000029192
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C86258; AU043625; D5Ertd110; mKIAA1322; D5Ertd110e; 2810413P16Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 21.3), testis adult (RPKM 18.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tbc1d14 in Genome Data Viewer
    Location:
    5 B3; 5 19.15 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (36647948..36743611, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (36490604..36586271, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (36833253..36928875, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene GrpE-like 1, mitochondrial Neighboring gene transcriptional adaptor 2B Neighboring gene coiled-coil domain containing 96 Neighboring gene predicted gene, 32528 Neighboring gene DNA segment, Chr 5, ERATO Doi 579, expressed Neighboring gene predicted gene, 32584 Neighboring gene predicted gene, 24878

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Clone Names

    • MGC102624

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in recycling endosome to Golgi transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in autophagosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in autophagosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    TBC1 domain family member 14

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113362.1NP_001106833.1  TBC1 domain family member 14 isoform a

      See identical proteins and their annotated locations for NP_001106833.1

      Status: VALIDATED

      Source sequence(s)
      AK029986, BC086316, BC096446
      Consensus CDS
      CCDS51480.1
      UniProtKB/Swiss-Prot
      Q8CGA2
      UniProtKB/TrEMBL
      G3UVU5, Q5U224
      Related
      ENSMUSP00000116519.2, ENSMUST00000130417.8
      Conserved Domains (2) summary
      smart00164
      Location:419651
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam15346
      Location:350392
      ARGLU; Arginine and glutamate-rich 1
    2. NM_001113364.1NP_001106835.1  TBC1 domain family member 14 isoform c

      See identical proteins and their annotated locations for NP_001106835.1

      Status: VALIDATED

      Source sequence(s)
      AB064521, BC086316, BC096446, BQ745653
      Consensus CDS
      CCDS51479.1
      UniProtKB/Swiss-Prot
      Q8CGA2
      UniProtKB/TrEMBL
      E9PYB1, Q5U224, Q76LY3
      Related
      ENSMUSP00000131876.2, ENSMUST00000171385.8
      Conserved Domains (2) summary
      smart00164
      Location:118350
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam17664
      Location:988
      DUF5526; Family of unknown function (DUF5526)
    3. NM_133910.3NP_598671.3  TBC1 domain family member 14 isoform b

      See identical proteins and their annotated locations for NP_598671.3

      Status: VALIDATED

      Source sequence(s)
      BC086316, BC096446, BQ769916
      Consensus CDS
      CCDS19240.2
      UniProtKB/Swiss-Prot
      Q8CGA2
      UniProtKB/TrEMBL
      E9Q8K4, Q5U224
      Related
      ENSMUSP00000031094.9, ENSMUST00000031094.15
      Conserved Domains (2) summary
      smart00164
      Location:399631
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam15346
      Location:330369
      ARGLU; Arginine and glutamate-rich 1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      36647948..36743611 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503645.1XP_006503708.1  TBC1 domain family member 14 isoform X5

      See identical proteins and their annotated locations for XP_006503708.1

      UniProtKB/TrEMBL
      E9PYB1
      Related
      ENSMUSP00000114508.2, ENSMUST00000126077.8
      Conserved Domains (2) summary
      smart00164
      Location:118350
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam17664
      Location:988
      DUF5526; Family of unknown function (DUF5526)
    2. XM_006503640.4XP_006503703.1  TBC1 domain family member 14 isoform X1

      See identical proteins and their annotated locations for XP_006503703.1

      UniProtKB/TrEMBL
      G3UVU5
      Related
      ENSMUSP00000117414.2, ENSMUST00000124036.8
      Conserved Domains (2) summary
      smart00164
      Location:419651
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam15346
      Location:350392
      ARGLU; Arginine and glutamate-rich 1
    3. XM_006503641.5XP_006503704.1  TBC1 domain family member 14 isoform X3

      See identical proteins and their annotated locations for XP_006503704.1

      UniProtKB/TrEMBL
      E9Q8K4
      Related
      ENSMUSP00000121516.2, ENSMUST00000140607.8
      Conserved Domains (2) summary
      smart00164
      Location:399631
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam15346
      Location:330369
      ARGLU; Arginine and glutamate-rich 1
    4. XM_036164700.1XP_036020593.1  TBC1 domain family member 14 isoform X3

      Conserved Domains (2) summary
      smart00164
      Location:399631
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam15346
      Location:330369
      ARGLU; Arginine and glutamate-rich 1
    5. XM_006503642.5XP_006503705.1  TBC1 domain family member 14 isoform X3

      See identical proteins and their annotated locations for XP_006503705.1

      UniProtKB/TrEMBL
      E9Q8K4
      Conserved Domains (2) summary
      smart00164
      Location:399631
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam15346
      Location:330369
      ARGLU; Arginine and glutamate-rich 1
    6. XM_036164699.1XP_036020592.1  TBC1 domain family member 14 isoform X2

      Related
      ENSMUSP00000115467.2, ENSMUST00000136189.8
      Conserved Domains (1) summary
      smart00164
      Location:399607
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    7. XM_036164703.1XP_036020596.1  TBC1 domain family member 14 isoform X7

      Conserved Domains (1) summary
      smart00164
      Location:58290
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    8. XM_006503644.5XP_006503707.1  TBC1 domain family member 14 isoform X4

      See identical proteins and their annotated locations for XP_006503707.1

      Conserved Domains (1) summary
      smart00164
      Location:169401
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    9. XM_036164702.1XP_036020595.1  TBC1 domain family member 14 isoform X6

      Conserved Domains (1) summary
      smart00164
      Location:118326
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    10. XM_036164704.1XP_036020597.1  TBC1 domain family member 14 isoform X7

      Conserved Domains (1) summary
      smart00164
      Location:58290
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    11. XM_006503647.5XP_006503710.1  TBC1 domain family member 14 isoform X7

      See identical proteins and their annotated locations for XP_006503710.1

      UniProtKB/TrEMBL
      Q921M0
      Conserved Domains (1) summary
      smart00164
      Location:58290
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    RNA

    1. XR_004942417.1 RNA Sequence

    2. XR_376793.3 RNA Sequence

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