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    Slc15a4 solute carrier family 15, member 4 [ Mus musculus (house mouse) ]

    Gene ID: 100561, updated on 23-Jun-2021

    Summary

    Official Symbol
    Slc15a4provided by MGI
    Official Full Name
    solute carrier family 15, member 4provided by MGI
    Primary source
    MGI:MGI:2140796
    See related
    Ensembl:ENSMUSG00000029416
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PT; PHT; PHT1; PTR4; AA987064; AW742963; C130069N12Rik
    Expression
    Ubiquitous expression in spleen adult (RPKM 27.6), mammary gland adult (RPKM 16.0) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Slc15a4 in Genome Data Viewer
    Location:
    5; 5 G1.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (127668795..127710356, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (127594545..127633292, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (128076036..128097762, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 132C, opposite strand Neighboring gene transmembrane protein 132C Neighboring gene predicted gene, 54294 Neighboring gene glycosyltransferase 1 domain containing 1 Neighboring gene transmembrane protein 132D Neighboring gene predicted gene, 33738

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in L-histidine transmembrane export from vacuole IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dipeptide import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histidine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histidine transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mast cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in oligopeptide transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within peptide transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptidoglycan transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidoglycan transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidoglycan transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of toll-like receptor 7 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of toll-like receptor 7 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of toll-like receptor 8 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of toll-like receptor 9 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of toll-like receptor 9 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of isotype switching to IgG isotypes IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of nucleotide-binding oligomerization domain containing signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in early endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endolysosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    solute carrier family 15 member 4
    Names
    peptide transporter 4
    peptide-histidine transporter 4
    peptide/histidine transporter 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133895.1NP_598656.1  solute carrier family 15 member 4

      See identical proteins and their annotated locations for NP_598656.1

      Status: PROVISIONAL

      Source sequence(s)
      BC016233
      Consensus CDS
      CCDS19688.1
      UniProtKB/Swiss-Prot
      Q91W98
      Related
      ENSMUSP00000031367.9, ENSMUST00000031367.15
      Conserved Domains (1) summary
      pfam00854
      Location:146519
      PTR2; POT family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      127668795..127710356 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504272.5XP_006504335.1  solute carrier family 15 member 4 isoform X2

      Conserved Domains (1) summary
      cl28910
      Location:16388
      MFS; Major Facilitator Superfamily
    2. XM_006504271.4XP_006504334.1  solute carrier family 15 member 4 isoform X1

      Conserved Domains (1) summary
      cl28910
      Location:27504
      MFS; Major Facilitator Superfamily

    RNA

    1. XR_004942415.1 RNA Sequence

    2. XR_004942414.1 RNA Sequence

    3. XR_003955563.2 RNA Sequence

    4. XR_001784584.3 RNA Sequence

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