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    RNF212B ring finger protein 212B [ Homo sapiens (human) ]

    Gene ID: 100507650, updated on 17-Jun-2024

    Summary

    Official Symbol
    RNF212Bprovided by HGNC
    Official Full Name
    ring finger protein 212Bprovided by HGNC
    Primary source
    HGNC:HGNC:20438
    See related
    Ensembl:ENSG00000215277 AllianceGenome:HGNC:20438
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C14orf164
    Summary
    Predicted to enable SUMO transferase activity. Predicted to be involved in homologous chromosome pairing at meiosis and protein sumoylation. Predicted to be active in synaptonemal complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in kidney (RPKM 3.6), testis (RPKM 2.0) and 20 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RNF212B in Genome Data Viewer
    Location:
    14q11.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (23185336..23273477)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (17386004..17474456)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (23654545..23742686)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8165 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23589263-23589793 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8166 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8167 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23592799-23593298 Neighboring gene CCAAT enhancer binding protein epsilon Neighboring gene Sharpr-MPRA regulatory region 2117 Neighboring gene solute carrier family 7 member 8 Neighboring gene RNA, U6 small nuclear 1138, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23641243-23641744 Neighboring gene uncharacterized LOC105370406 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:23667234-23668018 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr14:23675605-23676210 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:23706835-23707199 Neighboring gene ribosomal protein L39 pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 597 Neighboring gene RNA, U6 small nuclear 1046, pseudogene Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 1 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr14:23748940-23749440 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr14:23749441-23749941 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5602 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8168 Neighboring gene homeobox and leucine zipper encoding Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr14:23762790-23763654 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:23764306-23764618 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8169 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5603 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5604 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5605 Neighboring gene BCL2L2-PABPN1 readthrough Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23776901-23777734 Neighboring gene protein phosphatase 1 regulatory subunit 3E Neighboring gene H3 histone pseudogene 37 Neighboring gene BCL2 like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SUMO transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in homologous chromosome pairing at meiosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in reciprocal meiotic recombination IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in synaptonemal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    RING finger protein 212B
    Names
    RING finger protein C14orf164-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282322.3NP_001269251.1  RING finger protein 212B

      See identical proteins and their annotated locations for NP_001269251.1

      Status: VALIDATED

      Source sequence(s)
      AL049829
      Consensus CDS
      CCDS61401.1
      UniProtKB/Swiss-Prot
      A8MTL3
      Related
      ENSP00000397830.2, ENST00000430154.7
      Conserved Domains (1) summary
      cd16747
      Location:540
      RING-HC_RNF212B; RING finger, HC subclass, found in RING finger protein 212B (RNF212B) and similar proteins
    2. NM_001370218.3NP_001357147.1  RING finger protein 212B

      Status: VALIDATED

      Source sequence(s)
      AL049829, AL117258
      Consensus CDS
      CCDS61401.1
      UniProtKB/Swiss-Prot
      A8MTL3
      Related
      ENSP00000382794.1, ENST00000399910.5
      Conserved Domains (1) summary
      cd16747
      Location:540
      RING-HC_RNF212B; RING finger, HC subclass, found in RING finger protein 212B (RNF212B) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      23185336..23273477
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011536323.3XP_011534625.1  RING finger protein 212B isoform X3

      Conserved Domains (2) summary
      pfam14634
      Location:541
      zf-RING_5; zinc-RING finger domain
      cl01090
      Location:94151
      SlyX; SlyX
    2. XM_011536316.3XP_011534618.1  RING finger protein 212B isoform X1

      Conserved Domains (2) summary
      pfam14634
      Location:541
      zf-RING_5; zinc-RING finger domain
      cl01090
      Location:94151
      SlyX; SlyX
    3. XM_011536327.3XP_011534629.1  RING finger protein 212B isoform X4

      Conserved Domains (1) summary
      pfam14634
      Location:541
      zf-RING_5; zinc-RING finger domain
    4. XM_011536328.3XP_011534630.1  RING finger protein 212B isoform X5

    5. XM_011536319.3XP_011534621.1  RING finger protein 212B isoform X2

      See identical proteins and their annotated locations for XP_011534621.1

      Conserved Domains (1) summary
      pfam05600
      Location:2498
      DUF773; Protein of unknown function (DUF773)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      17386004..17474456
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054375245.1XP_054231220.1  RING finger protein 212B isoform X3

    2. XM_054375243.1XP_054231218.1  RING finger protein 212B isoform X1

    3. XM_054375246.1XP_054231221.1  RING finger protein 212B isoform X4

    4. XM_054375247.1XP_054231222.1  RING finger protein 212B isoform X5

    5. XM_054375244.1XP_054231219.1  RING finger protein 212B isoform X2