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    LRRC3C leucine rich repeat containing 3C [ Homo sapiens (human) ]

    Gene ID: 100505591, updated on 8-Mar-2024

    Summary

    Official Symbol
    LRRC3Cprovided by HGNC
    Official Full Name
    leucine rich repeat containing 3Cprovided by HGNC
    Primary source
    HGNC:HGNC:40034
    See related
    Ensembl:ENSG00000204913 AllianceGenome:HGNC:40034
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be integral component of membrane. Predicted to be active in extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 1.3), fat (RPKM 0.9) and 17 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See LRRC3C in Genome Data Viewer
    Location:
    17q21.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (39927732..39944999)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (40791446..40808715)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (38083985..38101252)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene gasdermin B Neighboring gene GSDMB 5' regulatory region Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38079584-38080370 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:38080371-38081156 Neighboring gene uncharacterized LOC124903999 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38083108-38083718 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38083719-38084330 Neighboring gene ORMDL sphingolipid biosynthesis regulator 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12119 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12118 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8468 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8469 Neighboring gene gasdermin A Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:38134870-38136069 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12120 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38136971-38137948 Neighboring gene uncharacterized LOC124904000 Neighboring gene proteasome 26S subunit, non-ATPase 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:38148510-38148687

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    General protein information

    Preferred Names
    leucine-rich repeat-containing protein 3C
    Names
    putative LRRC3-like protein ENSP00000367157

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195545.2NP_001182474.1  leucine-rich repeat-containing protein 3C precursor

      See identical proteins and their annotated locations for NP_001182474.1

      Status: VALIDATED

      Source sequence(s)
      AC090844
      Consensus CDS
      CCDS54121.1
      UniProtKB/Swiss-Prot
      A6NJW4
      Related
      ENSP00000367157.4, ENST00000377924.6
      Conserved Domains (3) summary
      sd00031
      Location:6180
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:82120
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:82140
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      39927732..39944999
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017024003.1XP_016879492.1  leucine-rich repeat-containing protein 3C isoform X1

      UniProtKB/Swiss-Prot
      A6NJW4
      Conserved Domains (3) summary
      sd00031
      Location:6180
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:82120
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:82140
      LRR_8; Leucine rich repeat

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      40791446..40808715
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054314638.1XP_054170613.1  leucine-rich repeat-containing protein 3C isoform X1

      UniProtKB/Swiss-Prot
      A6NJW4