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    Atg14 autophagy related 14 [ Mus musculus (house mouse) ]

    Gene ID: 100504663, updated on 31-Jan-2019

    Summary

    Official Symbol
    Atg14provided by MGI
    Official Full Name
    autophagy related 14provided by MGI
    Primary source
    MGI:MGI:1261775
    See related
    Ensembl:ENSMUSG00000037526
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Atg14L; 4832427M01; D14Ertd114e; D14Ertd436e
    Expression
    Ubiquitous expression in placenta adult (RPKM 4.7), CNS E18 (RPKM 4.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Atg14 in Genome Data Viewer
    Location:
    14 C1; 14 24.6 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (47540893..47568434, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (48130996..48194621, complement)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein S15 pseudogene Neighboring gene F-box protein 34 Neighboring gene predicted gene, 35166 Neighboring gene small nuclear ribonucleoprotein polypeptide F pseudogene Neighboring gene kinectin 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Autophagy - animal, organism-specific biosystem (from KEGG)
      Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Autophagy - animal, conserved biosystem (from KEGG)
      Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Cellular responses to stress, organism-specific biosystem (from REACTOME)
      Cellular responses to stress, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Macroautophagy, organism-specific biosystem (from REACTOME)
      Macroautophagy, organism-specific biosystemcomputationally inferred pathway (not manually curated)

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0831, MGC107607

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    autophagosome membrane docking ISO
    Inferred from Sequence Orthology
    more info
     
    autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to glucose starvation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to starvation ISO
    Inferred from Sequence Orthology
    more info
     
    endosome to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    macroautophagy ISO
    Inferred from Sequence Orthology
    more info
     
    mitophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitophagy ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    posttranscriptional regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of triglyceride metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to mitochondrial depolarisation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Mitochondria-associated ER Membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Mitochondria-associated ER Membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    autophagosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    autophagosome ISO
    Inferred from Sequence Orthology
    more info
     
    axoneme IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    extrinsic component of omegasome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extrinsic component of omegasome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of phagophore assembly site membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extrinsic component of phagophore assembly site membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    phagocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phagophore assembly site membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phagophore assembly site membrane ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol 3-kinase complex, class III IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol 3-kinase complex, class III IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    beclin 1-associated autophagy-related key regulator
    Names
    Atg14-like protein
    VATG14 autophagy related 14 homolog
    autophagy-related protein 14-like protein
    barkor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172599.4NP_766187.1  beclin 1-associated autophagy-related key regulator

      See identical proteins and their annotated locations for NP_766187.1

      Status: VALIDATED

      Source sequence(s)
      AK029967, AK054196, AW123154, BC090995
      Consensus CDS
      CCDS26989.1
      UniProtKB/Swiss-Prot
      Q8CDJ3
      Related
      ENSMUSP00000039047.6, ENSMUST00000042988.6
      Conserved Domains (1) summary
      pfam10186
      Location:43378
      Atg14; Vacuolar sorting 38 and autophagy-related subunit 14

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      47540893..47568434 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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