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    Atg14 autophagy related 14 [ Mus musculus (house mouse) ]

    Gene ID: 100504663, updated on 23-Jun-2021

    Summary

    Official Symbol
    Atg14provided by MGI
    Official Full Name
    autophagy related 14provided by MGI
    Primary source
    MGI:MGI:1261775
    See related
    Ensembl:ENSMUSG00000037526
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ba; Atg14L; 4832427M01; D14Ertd114; D14Ertd436; D14Ertd114e; D14Ertd436e
    Expression
    Ubiquitous expression in placenta adult (RPKM 4.7), CNS E18 (RPKM 4.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Atg14 in Genome Data Viewer
    Location:
    14 C1; 14 24.6 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (47778350..47805891, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (47540893..47568434, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (48130996..48194621, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S15 pseudogene Neighboring gene F-box protein 34 Neighboring gene predicted gene, 35166 Neighboring gene small nuclear ribonucleoprotein polypeptide F pseudogene Neighboring gene kinectin 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0831, MGC107607

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in autophagosome membrane docking ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to glucose starvation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to starvation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within endosome to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in macroautophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mitophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in posttranscriptional regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of triglyceride metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to mitochondrial depolarisation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in autophagosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in autophagosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axoneme IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extrinsic component of omegasome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extrinsic component of omegasome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extrinsic component of phagophore assembly site membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extrinsic component of phagophore assembly site membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitochondria-associated endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondria-associated endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in phagocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in phagophore assembly site membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of phosphatidylinositol 3-kinase complex, class III IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of phosphatidylinositol 3-kinase complex, class III IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    beclin 1-associated autophagy-related key regulator
    Names
    Atg14-like protein
    VATG14 autophagy related 14 homolog
    autophagy-related protein 14-like protein
    barkor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172599.4NP_766187.1  beclin 1-associated autophagy-related key regulator

      See identical proteins and their annotated locations for NP_766187.1

      Status: VALIDATED

      Source sequence(s)
      AK029967, AK054196, AW123154, BC090995
      Consensus CDS
      CCDS26989.1
      UniProtKB/Swiss-Prot
      Q8CDJ3
      Related
      ENSMUSP00000039047.7, ENSMUST00000042988.7
      Conserved Domains (1) summary
      pfam10186
      Location:43378
      Atg14; Vacuolar sorting 38 and autophagy-related subunit 14

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      47778350..47805891 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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