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    Rpl5 ribosomal protein L5 [ Mus musculus (house mouse) ]

    Gene ID: 100503670, updated on 22-Aug-2021

    Summary

    Official Symbol
    Rpl5provided by MGI
    Official Full Name
    ribosomal protein L5provided by MGI
    Primary source
    MGI:MGI:102854
    See related
    Ensembl:ENSMUSG00000058558
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    U21; U21RNA
    Annotation information
    Note: In NCBI's Build 37.2 annotation of the reference assembly, Rpl5, which was represented by GeneID:19983, was incorrectly annotated as an intronless gene on chromosome 7. It has now been determined that Rpl5 is a multi-exon gene on chromosome 5. Therefore, GeneID:19983 has been replaced by GeneID:100503670 to restore the correct chromosome 5 location. The chromosome 7 location represents an Rpl5 pseudogene, which is now represented by GeneID:100043295. [17 Jun 2014]
    Expression
    Broad expression in CNS E11.5 (RPKM 297.0), placenta adult (RPKM 283.2) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rpl5 in Genome Data Viewer
    Location:
    5 F; 5 52.23 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (108048388..108056871)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (107900508..107909005)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (108329547..108338024)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ecotropic viral integration site 5 Neighboring gene ubiquitin-conjugating enzyme E2D 2B Neighboring gene predicted gene, 42149 Neighboring gene small nucleolar RNA, C/D box 21 Neighboring gene predicted gene, 22270 Neighboring gene predicted gene, 26387 Neighboring gene divergent protein kinase domain 1A Neighboring gene predicted gene, 42150 Neighboring gene ribosomal protein S19, pseudogene 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC25420, MGC101934, MGC102309, MGC117998

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5S rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables 5S rRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA 5'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin ligase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of protein neddylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of isoleucine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of methionine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of threonine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in rRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ribosomal large subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in ribosomal large subunit assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ribosomal large subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of aminoacyl-tRNA synthetase multienzyme complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of cytosolic large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    60S ribosomal protein L5
    NP_058676.1
    XP_006534747.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016980.2NP_058676.1  60S ribosomal protein L5

      See identical proteins and their annotated locations for NP_058676.1

      Status: VALIDATED

      Source sequence(s)
      BC083318, CD774263, CJ073701, CV561106
      Consensus CDS
      CCDS39199.1
      UniProtKB/Swiss-Prot
      P47962
      UniProtKB/TrEMBL
      Q58EU6
      Related
      ENSMUSP00000080854.7, ENSMUST00000082223.13
      Conserved Domains (1) summary
      PTZ00069
      Location:1295
      PTZ00069; 60S ribosomal protein L5; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      108048388..108056871
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534684.4XP_006534747.1  60S ribosomal protein L5 isoform X1

      See identical proteins and their annotated locations for XP_006534747.1

      UniProtKB/TrEMBL
      Q3TKR5
      Conserved Domains (1) summary
      PTZ00069
      Location:1294
      PTZ00069; 60S ribosomal protein L5; Provisional
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