U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    tie1 tyrosine kinase with immunoglobulin like and EGF like domains 1 [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 100496664, updated on 8-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    tie1provided by Xenbase
    Official Full Name
    tyrosine kinase with immunoglobulin like and EGF like domains 1provided by Xenbase
    Primary source
    Xenbase:XB-GENE-922217
    See related
    Ensembl:ENSXETG00000009580
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: 4
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 4 NC_030680.2 (88376417..88420457)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 4 NC_030680.1 (75156246..75196290, complement)

    Chromosome 4 - NC_030680.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC116410421 Neighboring gene transmembrane protein 125 Neighboring gene leucine rich repeat containing 19 Neighboring gene MPL proto-oncogene, thrombopoietin receptor Neighboring gene serine-rich adhesin for platelets-like

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    tyrosine-protein kinase receptor Tie-1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030680.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      88376417..88420457
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_031900916.1 → XP_031756776.1  tyrosine-protein kinase receptor Tie-1 isoform X2

      UniProtKB/TrEMBL
      A0A8J1JJE7, F6TCI2
      Conserved Domains (7) summary
      smart00410
      Location:76 → 155
      IG_like; Immunoglobulin like
      cd00054
      Location:174 → 199
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00063
      Location:585 → 676
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05089
      Location:778 → 1074
      PTKc_Tie1; Catalytic domain of the Protein Tyrosine Kinase, Tie1
      pfam00041
      Location:400 → 463
      fn3; Fibronectin type III domain
      cd00096
      Location:293 → 297
      Ig; Ig strand A [structural motif]
      cl11960
      Location:293 → 384
      Ig; Immunoglobulin domain

    2. XM_002931604.5 → XP_002931650.3  tyrosine-protein kinase receptor Tie-1 isoform X1

      UniProtKB/TrEMBL
      A0A6I8S349, F6TCI2
      Related
      ENSXETP00000091273.2, ENSXETT00000086554.2
      Conserved Domains (7) summary
      smart00410
      Location:124 → 203
      IG_like; Immunoglobulin like
      cd00054
      Location:222 → 247
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00063
      Location:633 → 724
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05089
      Location:826 → 1122
      PTKc_Tie1; Catalytic domain of the Protein Tyrosine Kinase, Tie1
      pfam00041
      Location:448 → 511
      fn3; Fibronectin type III domain
      cd00096
      Location:341 → 345
      Ig; Ig strand A [structural motif]
      cl11960
      Location:341 → 432
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.