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    Osbpl9 oxysterol binding protein-like 9 [ Mus musculus (house mouse) ]

    Gene ID: 100273, updated on 24-Apr-2022

    Summary

    Official Symbol
    Osbpl9provided by MGI
    Official Full Name
    oxysterol binding protein-like 9provided by MGI
    Primary source
    MGI:MGI:1923784
    See related
    Ensembl:ENSMUSG00000028559 AllianceGenome:MGI:1923784
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Orp-9; AU015843; 2600011I06Rik
    Summary
    Predicted to enable sterol binding activity and sterol transporter activity. Predicted to act upstream of or within lipid transport. Predicted to be located in Golgi apparatus. Predicted to be active in cytosol; intracellular membrane-bounded organelle; and membrane. Is expressed in several structures, including central nervous system; ganglia; genitourinary system; immune system; and liver. Orthologous to human OSBPL9 (oxysterol binding protein like 9). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 17.6), kidney adult (RPKM 16.6) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Osbpl9 in Genome Data Viewer
    Location:
    4; 4 C7
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (108918342..109059469, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (109061145..109202272, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (108733750..108874845, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RAB3B, member RAS oncogene family Neighboring gene RIKEN cDNA 8030443G20 gene Neighboring gene nardilysin, N-arginine dibasic convertase, NRD convertase 1 Neighboring gene microRNA 761 Neighboring gene predicted gene, 32581 Neighboring gene predicted gene, 52703 Neighboring gene predicted gene, 46867 Neighboring gene predicted gene, 40225 Neighboring gene calreticulin 4 Neighboring gene epidermal growth factor receptor pathway substrate 15 Neighboring gene predicted gene, 52753

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC30367, MGC38458

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables sterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables sterol transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    oxysterol-binding protein-related protein 9
    Names
    OSBP-related protein 9

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134791.2NP_001128263.1  oxysterol-binding protein-related protein 9 isoform c

      See identical proteins and their annotated locations for NP_001128263.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (c) has multiple differences in the 5' UTR and 5' coding region, compared to variant a, resulting in a protein (isoform c) with a shorter and distinct N-terminus when compared to isoform a.
      Source sequence(s)
      AK035658, AL627406, BC089163, CJ088630
      Consensus CDS
      CCDS51257.1
      UniProtKB/TrEMBL
      Q5FWX7
      Related
      ENSMUSP00000124112.2, ENSMUST00000160271.8
      Conserved Domains (1) summary
      pfam01237
      Location:267613
      Oxysterol_BP; Oxysterol-binding protein
    2. NM_001346502.2NP_001333431.1  oxysterol-binding protein-related protein 9 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (d) contains an alternate, internal exon compared to variant a. It encodes isoform d, which is longer than isoform a.
      Source sequence(s)
      AK035658, AL627103, BE861957, CA318269, CK621564, CN692679, CO043799, DV651580
      Consensus CDS
      CCDS84775.1
      UniProtKB/TrEMBL
      A0A0A6YXH3
      Related
      ENSMUSP00000141991.2, ENSMUST00000194478.6
      Conserved Domains (2) summary
      cd13290
      Location:5106
      PH_ORP9; Human Oxysterol binding protein related protein 9 Pleckstrin homology (PH) domain
      pfam01237
      Location:387733
      Oxysterol_BP; Oxysterol-binding protein
    3. NM_001355190.1NP_001342119.1  oxysterol-binding protein-related protein 9 isoform e

      Status: VALIDATED

      Source sequence(s)
      AK035658, AL627406, BQ176735, BQ745311, BU706118, CD353630, CX563312, DV651580, DV657501
      Conserved Domains (1) summary
      pfam01237
      Location:199545
      Oxysterol_BP; Oxysterol-binding protein
    4. NM_001355191.1NP_001342120.1  oxysterol-binding protein-related protein 9 isoform e

      Status: VALIDATED

      Source sequence(s)
      AK035658, AL627406, BQ176735, BQ745311, BU706118, CX563312, DV651580, DV657501
      Conserved Domains (1) summary
      pfam01237
      Location:199545
      Oxysterol_BP; Oxysterol-binding protein
    5. NM_001368727.1NP_001355656.1  oxysterol-binding protein-related protein 9 isoform f

      Status: VALIDATED

      Source sequence(s)
      AL627103, AL627406
      Consensus CDS
      CCDS89802.1
      Related
      ENSMUSP00000030288.8, ENSMUST00000030288.14
      Conserved Domains (2) summary
      cd13290
      Location:5106
      PH_ORP9; Human Oxysterol binding protein related protein 9 Pleckstrin homology (PH) domain
      pfam01237
      Location:377723
      Oxysterol_BP; Oxysterol-binding protein
    6. NM_133885.4NP_598646.4  oxysterol-binding protein-related protein 9 isoform a

      See identical proteins and their annotated locations for NP_598646.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (a) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AK075981, AK131984, AL627103, AL627406
      Consensus CDS
      CCDS38835.2
      UniProtKB/TrEMBL
      E9PXZ2
      Related
      ENSMUSP00000124370.3, ENSMUST00000162787.9
      Conserved Domains (2) summary
      cd13290
      Location:5106
      PH_ORP9; Human Oxysterol binding protein related protein 9 Pleckstrin homology (PH) domain
      pfam01237
      Location:364710
      Oxysterol_BP; Oxysterol-binding protein
    7. NM_173350.3NP_775485.2  oxysterol-binding protein-related protein 9 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (b) has multiple differences in the 5' UTR and 5' coding region, compared to variant a, resulting in a protein (isoform b) with a shorter and distinct N-terminus when compared to isoform a.
      Source sequence(s)
      AK035658, AL627406, CJ088630
      Consensus CDS
      CCDS51258.1
      UniProtKB/Swiss-Prot
      A2A8Z1
      Related
      ENSMUSP00000081396.7, ENSMUST00000084366.13
      Conserved Domains (1) summary
      pfam01237
      Location:280626
      Oxysterol_BP; Oxysterol-binding protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      108918342..109059469 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502617.4XP_006502680.2  oxysterol-binding protein-related protein 9 isoform X1

      Related
      ENSMUSP00000124742.2, ENSMUST00000160774.8
      Conserved Domains (2) summary
      cd13290
      Location:5106
      PH_ORP9; Human Oxysterol binding protein related protein 9 Pleckstrin homology (PH) domain
      pfam01237
      Location:400746
      Oxysterol_BP; Oxysterol-binding protein
    2. XM_036163549.1XP_036019442.1  oxysterol-binding protein-related protein 9 isoform X7

      Conserved Domains (1) summary
      pfam01237
      Location:212558
      Oxysterol_BP; Oxysterol-binding protein
    3. XM_030253060.2XP_030108920.1  oxysterol-binding protein-related protein 9 isoform X8

      Conserved Domains (1) summary
      pfam01237
      Location:199545
      Oxysterol_BP; Oxysterol-binding protein
    4. XM_036163548.1XP_036019441.1  oxysterol-binding protein-related protein 9 isoform X7

      Conserved Domains (1) summary
      pfam01237
      Location:212558
      Oxysterol_BP; Oxysterol-binding protein
    5. XM_030253064.2XP_030108924.1  oxysterol-binding protein-related protein 9 isoform X9

      Conserved Domains (1) summary
      pfam01237
      Location:35381
      Oxysterol_BP; Oxysterol-binding protein
    6. XM_030253061.2XP_030108921.1  oxysterol-binding protein-related protein 9 isoform X8

      Conserved Domains (1) summary
      pfam01237
      Location:199545
      Oxysterol_BP; Oxysterol-binding protein
    7. XM_030253057.1XP_030108917.1  oxysterol-binding protein-related protein 9 isoform X2

      Conserved Domains (2) summary
      pfam01237
      Location:359705
      Oxysterol_BP; Oxysterol-binding protein
      cl17171
      Location:165
      PH-like; Pleckstrin homology-like domain
    8. XM_036163550.1XP_036019443.1  oxysterol-binding protein-related protein 9 isoform X9

      Conserved Domains (1) summary
      pfam01237
      Location:35381
      Oxysterol_BP; Oxysterol-binding protein
    9. XM_030253062.1XP_030108922.1  oxysterol-binding protein-related protein 9 isoform X8

      Conserved Domains (1) summary
      pfam01237
      Location:199545
      Oxysterol_BP; Oxysterol-binding protein
    10. XM_036163547.1XP_036019440.1  oxysterol-binding protein-related protein 9 isoform X5

      Conserved Domains (2) summary
      pfam01237
      Location:310656
      Oxysterol_BP; Oxysterol-binding protein
      cl17171
      Location:1339
      PH-like; Pleckstrin homology-like domain
    11. XM_036163546.1XP_036019439.1  oxysterol-binding protein-related protein 9 isoform X3

      Conserved Domains (2) summary
      pfam01237
      Location:333679
      Oxysterol_BP; Oxysterol-binding protein
      cl17171
      Location:1339
      PH-like; Pleckstrin homology-like domain
    12. XM_030253059.2XP_030108919.1  oxysterol-binding protein-related protein 9 isoform X6

      Related
      ENSMUSP00000125714.2, ENSMUST00000161363.2
      Conserved Domains (2) summary
      pfam01237
      Location:297643
      Oxysterol_BP; Oxysterol-binding protein
      cl17171
      Location:1339
      PH-like; Pleckstrin homology-like domain
    13. XM_030253063.1XP_030108923.1  oxysterol-binding protein-related protein 9 isoform X8

      Conserved Domains (1) summary
      pfam01237
      Location:199545
      Oxysterol_BP; Oxysterol-binding protein
    14. XM_011240378.1XP_011238680.1  oxysterol-binding protein-related protein 9 isoform X7

      See identical proteins and their annotated locations for XP_011238680.1

      UniProtKB/TrEMBL
      Q8R0G3
      Conserved Domains (1) summary
      pfam01237
      Location:212558
      Oxysterol_BP; Oxysterol-binding protein
    15. XM_030253058.2XP_030108918.1  oxysterol-binding protein-related protein 9 isoform X4

      Conserved Domains (2) summary
      pfam01237
      Location:320666
      Oxysterol_BP; Oxysterol-binding protein
      cl17171
      Location:1339
      PH-like; Pleckstrin homology-like domain
    16. XM_030253065.1XP_030108925.1  oxysterol-binding protein-related protein 9 isoform X9

      Conserved Domains (1) summary
      pfam01237
      Location:35381
      Oxysterol_BP; Oxysterol-binding protein