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    RASA4B RAS p21 protein activator 4B [ Homo sapiens (human) ]

    Gene ID: 100271927, updated on 5-Sep-2025
    Official Symbol
    RASA4Bprovided by HGNC
    Official Full Name
    RAS p21 protein activator 4Bprovided by HGNC
    Primary source
    HGNC:HGNC:35202
    See related
    Ensembl:ENSG00000170667 AllianceGenome:HGNC:35202
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable GTPase activator activity; phospholipid binding activity; and zinc ion binding activity. Predicted to be involved in cellular response to calcium ion; intracellular signal transduction; and negative regulation of Ras protein signal transduction. Predicted to be located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
    Expression
    Ubiquitous expression in endometrium (RPKM 22.0), brain (RPKM 17.5) and 24 other tissues See more
    Orthologs
    all
    NEW
    Try the new Gene table
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    See RASA4B in Genome Data Viewer
    Location:
    7q22.1
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (102479976..102517777, complement)
    RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (103797581..103835325, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (102120423..102158224, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene leucine rich repeats and WD repeat domain containing 1 Neighboring gene microRNA 4467 Neighboring gene RNA polymerase II subunit J Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102131046-102131546 Neighboring gene uncharacterized LOC124901715 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102151767-102152268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102152269-102152768 Neighboring gene Sharpr-MPRA regulatory region 3260 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:102156842-102157466 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102165421-102165922 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102165923-102166422 Neighboring gene POLR2J3-UPK3BL2 readthrough Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102179485-102180312 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102184221-102184721 Neighboring gene uroplakin 3B like 2 Neighboring gene speedy/RINGO cell cycle regulator family member E2

    Go to nucleotide: Graphics FASTA GenBank

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Related articles in PubMed

    1. CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway. Lockyer PJ, et al. Curr Biol, 2001 Jun 26. PMID 11448776
    2. The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA. Jaffray EG, et al. J Cell Biol, 2023 Apr 3. PMID 36880596, Free PMC Article
    3. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. Yao Z, et al. Mol Cell, 2017 Jan 19. PMID 28065597, Free PMC Article
    4. The DNA sequence of human chromosome 7. Hillier LW, et al. Nature, 2003 Jul 10. PMID 12853948
    5. Temporal modulation of the NF-κB RelA network in response to different types of DNA damage. Campbell AE, et al. Biochem J, 2021 Feb 12. PMID 33438746, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Review eQTL and phenotype association data in this region using PheGenI

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ50902

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    ras GTPase-activating protein 4B
    Names
    putative Ras GTPase-activating protein 4B

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277335.2 → NP_001264264.1  ras GTPase-activating protein 4B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC093668
      Consensus CDS
      CCDS59506.1
      UniProtKB/TrEMBL
      F5GXT2, Q2NL74
      Related
      ENSP00000440982.1, ENST00000541662.5
      Conserved Domains (5) summary
      cd04025
      Location:134 → 257
      C2B_RasA1_RasA4; C2 domain second repeat present in RasA1 and RasA4
      cd04054
      Location:6 → 126
      C2A_Rasal1_RasA4; C2 domain first repeat present in RasA1 and RasA4
      cd05395
      Location:265 → 550
      RasGAP_RASA4; Ras-GTPase Activating Domain of RASA4
      smart00323
      Location:244 → 605
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cl17171
      Location:542 → 635
      PH-like; Pleckstrin homology-like domain

    2. NM_001367767.2 → NP_001354696.1  ras GTPase-activating protein 4B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC093668
      Consensus CDS
      CCDS94160.1
      UniProtKB/Swiss-Prot
      C9J798
      UniProtKB/TrEMBL
      Q2NL74
      Related
      ENSP00000417895.1, ENST00000465829.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      102479976..102517777 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047419681.1 → XP_047275637.1  ras GTPase-activating protein 4B isoform X1

      UniProtKB/TrEMBL
      B7Z405, B7Z9G3, F8W6L0
      Related
      ENSP00000303968.6, ENST00000306682.6

    2. XM_047419684.1 → XP_047275640.1  ras GTPase-activating protein 4B isoform X3

      UniProtKB/TrEMBL
      B7Z9G3

    3. XM_047419685.1 → XP_047275641.1  ras GTPase-activating protein 4B isoform X3

      UniProtKB/TrEMBL
      B7Z9G3

    4. XM_047419686.1 → XP_047275642.1  ras GTPase-activating protein 4B isoform X4

    5. XM_047419682.1 → XP_047275638.1  ras GTPase-activating protein 4B isoform X2

      UniProtKB/TrEMBL
      A0A9L9PXW0, Q2NL74
      Related
      ENSP00000516751.1, ENST00000707123.1

    6. XM_047419683.1 → XP_047275639.1  ras GTPase-activating protein 4B isoform X5

    RNA

    1. XR_007059979.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      103797581..103835325 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356945.1 → XP_054212920.1  ras GTPase-activating protein 4B isoform X1

      UniProtKB/TrEMBL
      B7Z405, B7Z9G3

    2. XM_054356947.1 → XP_054212922.1  ras GTPase-activating protein 4B isoform X3

      UniProtKB/TrEMBL
      B7Z9G3

    3. XM_054356948.1 → XP_054212923.1  ras GTPase-activating protein 4B isoform X3

      UniProtKB/TrEMBL
      B7Z9G3

    4. XM_054356950.1 → XP_054212925.1  ras GTPase-activating protein 4B isoform X4

    5. XM_054356944.1 → XP_054212919.1  ras GTPase-activating protein 4B isoform X6

      UniProtKB/TrEMBL
      Q2NL74

    6. XM_054356946.1 → XP_054212921.1  ras GTPase-activating protein 4B isoform X2

      UniProtKB/TrEMBL
      Q2NL74

    7. XM_054356949.1 → XP_054212924.1  ras GTPase-activating protein 4B isoform X7

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C9J798.2 GenPept UniProtKB/Swiss-Prot:C9J798

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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