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    RASA4B RAS p21 protein activator 4B [ Homo sapiens (human) ]

    Gene ID: 100271927, updated on 3-Apr-2024

    Summary

    Official Symbol
    RASA4Bprovided by HGNC
    Official Full Name
    RAS p21 protein activator 4Bprovided by HGNC
    Primary source
    HGNC:HGNC:35202
    See related
    Ensembl:ENSG00000170667 AllianceGenome:HGNC:35202
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable GTPase activator activity; metal ion binding activity; and phospholipid binding activity. Predicted to be involved in several processes, including cellular response to calcium ion; negative regulation of Ras protein signal transduction; and regulation of GTPase activity. Predicted to be located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in endometrium (RPKM 22.0), brain (RPKM 17.5) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RASA4B in Genome Data Viewer
    Location:
    7q22.1
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (102479976..102517777, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (103797581..103835325, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (102120423..102158224, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene leucine rich repeats and WD repeat domain containing 1 Neighboring gene microRNA 4467 Neighboring gene RNA polymerase II subunit J Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102131046-102131546 Neighboring gene uncharacterized LOC124901715 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102151767-102152268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102152269-102152768 Neighboring gene Sharpr-MPRA regulatory region 3260 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:102156842-102157466 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102165421-102165922 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102165923-102166422 Neighboring gene POLR2J3-UPK3BL2 readthrough Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102179485-102180312 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:102184221-102184721 Neighboring gene uroplakin 3B like 2 Neighboring gene speedy/RINGO cell cycle regulator family member E2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ50902

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ras GTPase-activating protein 4B
    Names
    putative Ras GTPase-activating protein 4B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277335.2NP_001264264.1  ras GTPase-activating protein 4B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC093668
      Consensus CDS
      CCDS59506.1
      UniProtKB/TrEMBL
      F5GXT2, Q2NL74
      Related
      ENSP00000440982.1, ENST00000541662.5
      Conserved Domains (5) summary
      cd04025
      Location:134257
      C2B_RasA1_RasA4; C2 domain second repeat present in RasA1 and RasA4
      cd04054
      Location:6126
      C2A_Rasal1_RasA4; C2 domain first repeat present in RasA1 and RasA4
      cd05395
      Location:265550
      RasGAP_RASA4; Ras-GTPase Activating Domain of RASA4
      smart00323
      Location:244605
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cl17171
      Location:542635
      PH-like; Pleckstrin homology-like domain
    2. NM_001367767.2NP_001354696.1  ras GTPase-activating protein 4B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC093668
      Consensus CDS
      CCDS94160.1
      UniProtKB/Swiss-Prot
      C9J798
      UniProtKB/TrEMBL
      Q2NL74
      Related
      ENSP00000417895.1, ENST00000465829.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      102479976..102517777 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047419681.1XP_047275637.1  ras GTPase-activating protein 4B isoform X1

      UniProtKB/TrEMBL
      F8W6L0
      Related
      ENSP00000303968.6, ENST00000306682.6
    2. XM_047419684.1XP_047275640.1  ras GTPase-activating protein 4B isoform X3

    3. XM_047419685.1XP_047275641.1  ras GTPase-activating protein 4B isoform X3

    4. XM_047419686.1XP_047275642.1  ras GTPase-activating protein 4B isoform X4

    5. XM_047419682.1XP_047275638.1  ras GTPase-activating protein 4B isoform X2

      UniProtKB/TrEMBL
      A0A9L9PXW0
      Related
      ENSP00000516751.1, ENST00000707123.1
    6. XM_047419683.1XP_047275639.1  ras GTPase-activating protein 4B isoform X5

    RNA

    1. XR_007059979.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      103797581..103835325 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356945.1XP_054212920.1  ras GTPase-activating protein 4B isoform X1

    2. XM_054356947.1XP_054212922.1  ras GTPase-activating protein 4B isoform X3

    3. XM_054356948.1XP_054212923.1  ras GTPase-activating protein 4B isoform X3

    4. XM_054356950.1XP_054212925.1  ras GTPase-activating protein 4B isoform X4

    5. XM_054356944.1XP_054212919.1  ras GTPase-activating protein 4B isoform X6

    6. XM_054356946.1XP_054212921.1  ras GTPase-activating protein 4B isoform X2

    7. XM_054356949.1XP_054212924.1  ras GTPase-activating protein 4B isoform X7