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    ARHGEF33 Rho guanine nucleotide exchange factor 33 [ Homo sapiens (human) ]

    Gene ID: 100271715, updated on 5-May-2024

    Summary

    Official Symbol
    ARHGEF33provided by HGNC
    Official Full Name
    Rho guanine nucleotide exchange factor 33provided by HGNC
    Primary source
    HGNC:HGNC:37252
    See related
    Ensembl:ENSG00000214694 AllianceGenome:HGNC:37252
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of catalytic activity. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis (RPKM 1.6), brain (RPKM 0.5) and 12 other tissues See more
    Orthologs
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    Genomic context

    See ARHGEF33 in Genome Data Viewer
    Location:
    2p22.1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (38889875..38975454)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (38898364..38983970)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (39117016..39202595)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:39102285-39103268 Neighboring gene RNA, U6 small nuclear 851, pseudogene Neighboring gene MORN repeat containing 2 Neighboring gene uncharacterized LOC105374471 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:39170060-39171010 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:39174178-39174678 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:39174679-39175179 Neighboring gene RNA, 7SL, cytoplasmic 96, pseudogene Neighboring gene uncharacterized LOC375196 Neighboring gene SOS Ras/Rac guanine nucleotide exchange factor 1 Neighboring gene MPRA-validated peak3669 silencer Neighboring gene RNA, U6 small nuclear 198, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11383 Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 13

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    rho guanine nucleotide exchange factor 33
    Names
    DH and coiled-coil domain-containing protein ENSP00000381780
    Rho guanine nucleotide exchange factor (GEF) 33

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145451.5NP_001138923.2  rho guanine nucleotide exchange factor 33 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC018693, AC019171
      Consensus CDS
      CCDS46263.2
      UniProtKB/TrEMBL
      A0A8V8TLC5
      Related
      ENSP00000387020.1, ENST00000409978.7
      Conserved Domains (1) summary
      cl02571
      Location:269445
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    2. NM_001367623.3NP_001354552.1  rho guanine nucleotide exchange factor 33 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC018693, AC019171
      UniProtKB/Swiss-Prot
      A8MVX0, J3KPX2
      UniProtKB/TrEMBL
      A0A8V8TLC5
      Conserved Domains (3) summary
      COG1196
      Location:21127
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK12323
      Location:463688
      PRK12323; DNA polymerase III subunit gamma/tau
      cl02571
      Location:269436
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      38889875..38975454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      38898364..38983970
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)