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    enah ENAH, actin regulator [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 100144977, updated on 8-Mar-2025

    Summary

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    Official Symbol
    enahprovided by Xenbase
    Official Full Name
    ENAH, actin regulatorprovided by Xenbase
    Primary source
    Xenbase:XB-GENE-993747
    See related
    Ensembl:ENSXETG00000018550 AllianceGenome:Xenbase:XB-GENE-993747
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Also known as
    Ena; Xena; mena; ndpp1
    Summary
    Predicted to enable profilin binding activity. Predicted to be involved in actin polymerization or depolymerization; actin polymerization-dependent cell motility; and axon guidance. Predicted to be located in cytoplasm; cytoskeleton; and lamellipodium. Predicted to be active in focal adhesion and plasma membrane. Orthologous to human ENAH (ENAH actin regulator). [provided by Alliance of Genome Resources, Mar 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See enah in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 5 NC_030681.2 (8477886..8536116)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 5 NC_030681.1 (4723425..4779363)

    Chromosome 5 - NC_030681.2Genomic Context describing neighboring genes Neighboring gene transfer RNA alanine (anticodon UGC) Neighboring gene signal recognition particle 9kDa Neighboring gene uncharacterized LOC116410903 Neighboring gene lamin B receptor Neighboring gene dynein axonemal heavy chain 14 Neighboring gene cornichon family AMPA receptor auxiliary protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables profilin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin polymerization-dependent cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein enabled homolog
    Names
    enabled homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126543.1 → NP_001120015.1  protein enabled homolog

      See identical proteins and their annotated locations for NP_001120015.1

      Status: PROVISIONAL

      Source sequence(s)
      BC158313
      UniProtKB/TrEMBL
      A0A6I8SU09, B0BM72
      Related
      ENSXETP00000101331.2, ENSXETT00000083991.2
      Conserved Domains (2) summary
      cd01207
      Location:5 → 112
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:498 → 531
      VASP_tetra; VASP tetramerization domain

    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030681.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      8477886..8536116
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_012962711.3 → XP_012818165.2  protein enabled homolog isoform X1

      UniProtKB/TrEMBL
      A0A6I8PY04, A0A6I8S8I0
      Related
      ENSXETP00000091111.2, ENSXETT00000070384.2
      Conserved Domains (2) summary
      cd01207
      Location:5 → 112
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:758 → 792
      VASP_tetra; VASP tetramerisation domain

    2. XM_012962712.3 → XP_012818166.1  protein enabled homolog isoform X2

      UniProtKB/TrEMBL
      A0A8J0SNB0
      Conserved Domains (2) summary
      cd01207
      Location:5 → 112
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:535 → 569
      VASP_tetra; VASP tetramerisation domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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