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    KLLN killin, p53 regulated DNA replication inhibitor [ Homo sapiens (human) ]

    Gene ID: 100144748, updated on 2-May-2024

    Summary

    Official Symbol
    KLLNprovided by HGNC
    Official Full Name
    killin, p53 regulated DNA replication inhibitorprovided by HGNC
    Primary source
    HGNC:HGNC:37212
    See related
    Ensembl:ENSG00000227268 MIM:612105; AllianceGenome:HGNC:37212
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CWS4; KILLIN
    Summary
    The protein encoded by this intronless gene is found in the nucleus, where it can inhibit DNA synthesis and promote S phase arrest coupled to apoptosis. The expression of this DNA binding protein is upregulated by transcription factor p53. [provided by RefSeq, Dec 2012]
    Orthologs
    NEW
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    Genomic context

    See KLLN in Genome Data Viewer
    Location:
    10q23.31
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (87859158..87863533, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (88743061..88747436, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (89618915..89623290, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902476 Neighboring gene ATPase family AAA domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2584 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3713 Neighboring gene cofilin 1 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 3344 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:89602409-89603608 Neighboring gene RNA, 7SL, cytoplasmic 78, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3714 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3715 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3716 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2585 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2586 Neighboring gene phosphatase and tensin homolog Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2587 Neighboring gene ribosomal protein L11 pseudogene 3 Neighboring gene small nucleolar RNA SNORD74

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033079.1 RefSeqGene

      Range
      4905..9280
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1087

    mRNA and Protein(s)

    1. NM_001126049.2NP_001119521.1  killin

      See identical proteins and their annotated locations for NP_001119521.1

      Status: REVIEWED

      Source sequence(s)
      AC063965
      Consensus CDS
      CCDS44454.1
      UniProtKB/Swiss-Prot
      B2CW77
      Related
      ENSP00000392204.2, ENST00000445946.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      87859158..87863533 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_013171807.1 Reference GRCh38.p14 PATCHES

      Range
      74981..79357 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      88743061..88747436 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)