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    ZNF705B zinc finger protein 705B [ Homo sapiens (human) ]

    Gene ID: 100132396, updated on 11-Apr-2024

    Summary

    Official Symbol
    ZNF705Bprovided by HGNC
    Official Full Name
    zinc finger protein 705Bprovided by HGNC
    Primary source
    HGNC:HGNC:32284
    See related
    Ensembl:ENSG00000215356 AllianceGenome:HGNC:32284
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis (RPKM 1.0) See more
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    Genomic context

    See ZNF705B in Genome Data Viewer
    Location:
    8p23.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (7926337..7952413)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (12072289..12100603)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (7783859..7809935)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene translation initiation factor IF-2-like Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:7760080-7761002 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:7761003-7761923 Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 2 Neighboring gene defensin beta 4A Neighboring gene defensin beta 108A Neighboring gene ubiquitin carboxyl-terminal hydrolase 17-like protein 2-like Neighboring gene family with sequence similarity 66 member E Neighboring gene ubiquitin specific peptidase 17 like family member 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    zinc finger protein 705B
    Names
    Putative zinc finger protein 705D-like protein LOC100132396
    putative zinc finger protein 705B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193630.1NP_001180559.1  zinc finger protein 705B

      See identical proteins and their annotated locations for NP_001180559.1

      Status: VALIDATED

      Source sequence(s)
      AC130365, AK292586
      Consensus CDS
      CCDS55194.1
      UniProtKB/Swiss-Prot
      A8K971, A8MY01, P0CI00
      Related
      ENSP00000382987.3, ENST00000400120.3
      Conserved Domains (5) summary
      smart00349
      Location:766
      KRAB; krueppel associated box
      COG5048
      Location:116300
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:174194
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:746
      KRAB; KRAB box
      pfam13465
      Location:214239
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      7926337..7952413
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421207.1XP_047277163.1  zinc finger protein 705B isoform X1

      UniProtKB/Swiss-Prot
      A8K971, A8MY01, P0CI00
    2. XM_047421208.1XP_047277164.1  zinc finger protein 705B isoform X1

      UniProtKB/Swiss-Prot
      A8K971, A8MY01, P0CI00

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654717.1 Reference GRCh38.p14 PATCHES

      Range
      833818..861427
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332231.1XP_054188206.1  zinc finger protein 705B isoform X1

    2. XM_054332230.1XP_054188205.1  zinc finger protein 705B isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      12072289..12100603
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359524.1XP_054215499.1  zinc finger protein 705B isoform X1