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    Srp54c signal recognition particle 54C [ Mus musculus (house mouse) ]

    Gene ID: 100101806, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Srp54cprovided by MGI
    Official Full Name
    signal recognition particle 54Cprovided by MGI
    Primary source
    MGI:MGI:3714359
    See related
    Ensembl:ENSMUSG00000079108 AllianceGenome:MGI:3714359
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E330029E12Rik
    Summary
    Predicted to enable 7S RNA binding activity; endoplasmic reticulum signal peptide binding activity; and guanyl ribonucleotide binding activity. Predicted to contribute to GTPase activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, translocation and granulocyte differentiation. Predicted to be located in nucleus. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in severe congenital neutropenia 8. Orthologous to human SRP54 (signal recognition particle 54). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 30.5), bladder adult (RPKM 26.6) and 28 other tissues See more
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    Genomic context

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    See Srp54c in Genome Data Viewer
    Location:
    12 C1; 12 23.89 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (55276896..55326120)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (55230118..55279331)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr12:56256085-56256386 Neighboring gene signal recognition particle 54B Neighboring gene family with sequence similarity 177 member A2 Neighboring gene STARR-positive B cell enhancer mm9_chr12:56329932-56330232 Neighboring gene predicted gene 2446 Neighboring gene protein phosphatase 2, regulatory subunit B'', gamma Neighboring gene STARR-positive B cell enhancer ABC_E3052 Neighboring gene STARR-positive B cell enhancer ABC_E3053 Neighboring gene protein only RNase P catalytic subunit Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:56490469-56490652 Neighboring gene ribosomal protein L18A, pseudogene 1 Neighboring gene proteasome subunit alpha 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC6231

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 7S RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 7S RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables endoplasmic reticulum signal peptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endoplasmic reticulum signal peptide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in granulocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to ER ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of signal recognition particle, endoplasmic reticulum targeting IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of signal recognition particle, endoplasmic reticulum targeting ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    signal recognition particle 54C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100110.2 → NP_001093580.1  signal recognition particle 54C isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC174776
      Consensus CDS
      CCDS49067.1
      UniProtKB/TrEMBL
      E9PXC0, Q8C1Y6
      Related
      ENSMUSP00000151681.2, ENSMUST00000218879.2
      Conserved Domains (1) summary
      TIGR01425
      Location:2 → 430
      SRP54_euk; signal recognition particle protein SRP54

    2. NM_001377038.1 → NP_001363967.1  signal recognition particle 54C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC166323, AC174776
      UniProtKB/TrEMBL
      Q99JZ9
      Conserved Domains (1) summary
      TIGR01425
      Location:2 → 430
      SRP54_euk; signal recognition particle protein SRP54

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      55276896..55326120
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157136.1 → XP_036013029.1  signal recognition particle 54C isoform X2

      UniProtKB/TrEMBL
      Q99JZ9
      Conserved Domains (2) summary
      TIGR01425
      Location:2 → 430
      SRP54_euk; signal recognition particle protein SRP54
      pfam14774
      Location:468 → 500
      FAM177; FAM177 family

    2. XM_011243971.4 → XP_011242273.1  signal recognition particle 54C isoform X1

      Conserved Domains (1) summary
      TIGR01425
      Location:4 → 291
      SRP54_euk; signal recognition particle protein SRP54
    Nucleotide Protein Strain
    Heading Accession and Version

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