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    Tigit T cell immunoreceptor with Ig and ITIM domains [ Mus musculus (house mouse) ]

    Gene ID: 100043314, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tigitprovided by MGI
    Official Full Name
    T cell immunoreceptor with Ig and ITIM domainsprovided by MGI
    Primary source
    MGI:MGI:3642260
    See related
    Ensembl:ENSMUSG00000071552 AllianceGenome:MGI:3642260
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Vstm3
    Summary
    Enables signaling receptor binding activity. Acts upstream of or within negative regulation of T cell activation. Predicted to be located in plasma membrane. Predicted to be active in cell surface. Orthologous to human TIGIT (T cell immunoreceptor with Ig and ITIM domains). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in large intestine adult (RPKM 1.9), small intestine adult (RPKM 1.8) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tigit in Genome Data Viewer
    Location:
    16 B4; 16 28.44 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (43469224..43485494, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (43626137..43665125, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 20 Neighboring gene STARR-seq mESC enhancer starr_40880 Neighboring gene predicted gene 15713 Neighboring gene STARR-seq mESC enhancer starr_40881 Neighboring gene STARR-positive B cell enhancer mm9_chr16:43507109-43507410 Neighboring gene STARR-seq mESC enhancer starr_40882 Neighboring gene STARR-seq mESC enhancer starr_40883 Neighboring gene STARR-seq mESC enhancer starr_40885 Neighboring gene STARR-positive B cell enhancer ABC_E7450 Neighboring gene STARR-positive B cell enhancer ABC_E4170 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:43690256-43690365 Neighboring gene STARR-positive B cell enhancer mm9_chr16:43698828-43699128 Neighboring gene STARR-seq mESC enhancer starr_40886 Neighboring gene STARR-positive B cell enhancer ABC_E1923 Neighboring gene microRNA 568 Neighboring gene predicted gene, 53956 Neighboring gene STARR-seq mESC enhancer starr_40887 Neighboring gene dopamine receptor D3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    T-cell immunoreceptor with Ig and ITIM domains
    Names
    V-set and transmembrane domain containing 3
    V-set and transmembrane domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146325.2NP_001139797.1  T-cell immunoreceptor with Ig and ITIM domains precursor

      See identical proteins and their annotated locations for NP_001139797.1

      Status: VALIDATED

      Source sequence(s)
      AC120871, AC154408
      Consensus CDS
      CCDS49852.1
      UniProtKB/Swiss-Prot
      P86176
      UniProtKB/TrEMBL
      A0A0B4J1G6
      Related
      ENSMUSP00000093770.5, ENSMUST00000096065.6
      Conserved Domains (2) summary
      smart00410
      Location:32127
      IG_like; Immunoglobulin like
      cl11960
      Location:40128
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      43469224..43485494 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316834.3XP_017172323.1  T-cell immunoreceptor with Ig and ITIM domains isoform X1

      Conserved Domains (1) summary
      cl11960
      Location:40128
      Ig; Immunoglobulin domain