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    NAALADL1 N-acetylated alpha-linked acidic dipeptidase like 1 [ Homo sapiens (human) ]

    Gene ID: 10004, updated on 25-May-2017
    Official Symbol
    NAALADL1provided by HGNC
    Official Full Name
    N-acetylated alpha-linked acidic dipeptidase like 1provided by HGNC
    Primary source
    HGNC:HGNC:23536
    See related
    Ensembl:ENSG00000168060 MIM:602640; Vega:OTTHUMG00000165595
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    I100; NAALADASEL
    Orthologs
    Location:
    11q13.1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (65044818..65059020, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64812295..64826009, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ARL2-SNX15 readthrough (NMD candidate) Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 18 Neighboring gene sorting nexin 15 Neighboring gene SAC3 domain containing 1 Neighboring gene cell division cycle associated 5 Neighboring gene zinc finger protein like 1 Neighboring gene transmembrane protein 262

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    dipeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Preferred Names
    N-acetylated-alpha-linked acidic dipeptidase-like protein
    Names
    100 kDa ileum brush border membrane protein
    NAALADase L
    ileal dipeptidylpeptidase
    ileal peptidase I100
    peptidase homolog
    NP_005459.2
    XP_011543008.1
    XP_011543009.1
    XP_011543010.1
    XP_011543011.1
    XP_011543012.1
    XP_011543013.1
    XP_011543014.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005468.2NP_005459.2  N-acetylated-alpha-linked acidic dipeptidase-like protein

      See identical proteins and their annotated locations for NP_005459.2

      Status: VALIDATED

      Source sequence(s)
      AJ012371, AP003068, BG757994, BM681269
      Consensus CDS
      CCDS31604.1
      UniProtKB/Swiss-Prot
      Q9UQQ1
      Related
      ENSP00000351484.3, OTTHUMP00000230362, ENST00000358658.7, OTTHUMT00000385162
      Conserved Domains (4) summary
      cd08022
      Location:332587
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      cd02121
      Location:109335
      PA_GCPII_like; PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to ...
      pfam04253
      Location:621735
      TFR_dimer; Transferrin receptor-like dimerization domain
      cl14876
      Location:51132
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

      Range
      65044818..65059020 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011544707.2XP_011543009.1  N-acetylated-alpha-linked acidic dipeptidase-like protein isoform X2

      Conserved Domains (4) summary
      cd08022
      Location:284539
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      cd02121
      Location:61287
      PA_GCPII_like; PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to ...
      pfam04253
      Location:573687
      TFR_dimer; Transferrin receptor-like dimerization domain
      cl14876
      Location:384
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
    2. XM_011544708.2XP_011543010.1  N-acetylated-alpha-linked acidic dipeptidase-like protein isoform X3

      Conserved Domains (3) summary
      cd02121
      Location:109335
      PA_GCPII_like; PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to ...
      pfam04253
      Location:568682
      TFR_dimer; Transferrin receptor-like dimerization domain
      cl14876
      Location:332534
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
    3. XM_011544706.2XP_011543008.1  N-acetylated-alpha-linked acidic dipeptidase-like protein isoform X1

      Conserved Domains (3) summary
      cd02121
      Location:109335
      PA_GCPII_like; PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to ...
      pfam04253
      Location:618732
      TFR_dimer; Transferrin receptor-like dimerization domain
      cl14876
      Location:332584
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
    4. XM_011544710.2XP_011543012.1  N-acetylated-alpha-linked acidic dipeptidase-like protein isoform X5

      UniProtKB/Swiss-Prot
      Q9UQQ1
      Conserved Domains (2) summary
      cd02121
      Location:109335
      PA_GCPII_like; PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to ...
      cl14876
      Location:332485
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
    5. XM_011544709.2XP_011543011.1  N-acetylated-alpha-linked acidic dipeptidase-like protein isoform X4

      Conserved Domains (2) summary
      cd02121
      Location:109335
      PA_GCPII_like; PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to ...
      cl14876
      Location:332536
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
    6. XM_011544712.2XP_011543014.1  N-acetylated-alpha-linked acidic dipeptidase-like protein isoform X6

      See identical proteins and their annotated locations for XP_011543014.1

      Conserved Domains (2) summary
      cd02121
      Location:109335
      PA_GCPII_like; PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to ...
      cl14876
      Location:332454
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
    7. XM_011544711.2XP_011543013.1  N-acetylated-alpha-linked acidic dipeptidase-like protein isoform X6

      See identical proteins and their annotated locations for XP_011543013.1

      Conserved Domains (2) summary
      cd02121
      Location:109335
      PA_GCPII_like; PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to ...
      cl14876
      Location:332454
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    RNA

    1. XR_001747713.1 RNA Sequence

    2. XR_001747712.1 RNA Sequence

    3. XR_949724.2 RNA Sequence

      Related
      ENST00000529274.5
    4. XR_949728.2 RNA Sequence

    5. XR_949727.2 RNA Sequence

    6. XR_949730.2 RNA Sequence

    7. XR_949729.2 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      64695983..64709697 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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