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    NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2 [ Homo sapiens (human) ]

    Gene ID: 10003, updated on 5-Mar-2024

    Summary

    Official Symbol
    NAALAD2provided by HGNC
    Official Full Name
    N-acetylated alpha-linked acidic dipeptidase 2provided by HGNC
    Primary source
    HGNC:HGNC:14526
    See related
    Ensembl:ENSG00000077616 MIM:611636; AllianceGenome:HGNC:14526
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GCP3; GCPIII; GPCIII
    Summary
    This gene is a member of the N-acetylated alpha-linked acidic dipeptidase (NAALADase) gene family. The representative member of this family is the gene encoding human prostate-specific membrane antigen (PSM), which is a marker of prostatic carcinomas and is the first to be shown to possess NAALADase activity. NAALADase cleaves N-acetyl-L-aspartate-L-glutamate (NAAG), which is a neuropeptide expressed both in the central nervous systems and in the periphery and is thought to function as a neurotransmitter. The product of this gene is a type II integral membrane protein. Transient transfection of this gene confers both NAALADase and dipetidyl peptidase IV activities to mammalian cells. This gene is highly expressed in ovary and testis as well as within discrete brain areas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
    Expression
    Broad expression in testis (RPKM 7.2), adrenal (RPKM 5.0) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NAALAD2 in Genome Data Viewer
    Location:
    11q14.3
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (90131699..90192894)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (90051780..90112974)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (89867831..89926062)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:89828635-89829290 Neighboring gene upstream binding transcription factor like 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:89837329-89837830 Neighboring gene small nucleolar RNA SNORD56 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:89867735-89868438 Neighboring gene MPRA-validated peak1387 silencer Neighboring gene cysteine and histidine rich domain containing 1 Neighboring gene uncharacterized LOC124902812 Neighboring gene NANOG hESC enhancer GRCh37_chr11:89961208-89961714

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC26353, MGC116996

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables carboxypeptidase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables dipeptidase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables dipeptidyl-peptidase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metallocarboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables serine-type peptidase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    N-acetylated-alpha-linked acidic dipeptidase 2
    Names
    N-acetylated alpha-linked acidic dipeptidase II
    NAALADASE2
    NAALADase II
    glutamate carboxypeptidase III
    NP_001287859.1
    NP_005458.1
    XP_016872532.1
    XP_016872534.1
    XP_016872535.1
    XP_047282124.1
    XP_054188397.1
    XP_054188398.1
    XP_054188399.1
    XP_054188400.1
    XP_054223318.1
    XP_054223319.1
    XP_054223320.1
    XP_054223321.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001300930.2NP_001287859.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform 2

      See identical proteins and their annotated locations for NP_001287859.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AJ012370, AP000648, BC088727, BU618706, CN355388
      Consensus CDS
      CCDS73364.1
      UniProtKB/TrEMBL
      J3KNJ3
      Related
      ENSP00000320083.4, ENST00000321955.8
      Conserved Domains (3) summary
      cd08022
      Location:305552
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      cd02121
      Location:110296
      PA_GCPII_like; PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to ...
      pfam04253
      Location:589704
      TFR_dimer; Transferrin receptor-like dimerization domain
    2. NM_005467.4NP_005458.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform 1

      See identical proteins and their annotated locations for NP_005458.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AJ012370, AK075390, AP000648, CN355388
      Consensus CDS
      CCDS8288.1
      UniProtKB/Swiss-Prot
      B3KQR4, Q4KKV4, Q4VAM9, Q9Y3Q0
      Related
      ENSP00000432481.1, ENST00000534061.6
      Conserved Domains (4) summary
      cd08022
      Location:338585
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      cd02121
      Location:110336
      PA_GCPII_like; PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to ...
      pfam04253
      Location:622737
      TFR_dimer; Transferrin receptor-like dimerization domain
      cl14876
      Location:58104
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      90131699..90192894
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017017043.3XP_016872532.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X1

      Conserved Domains (4) summary
      cd08022
      Location:373620
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      cd02121
      Location:145371
      PA_GCPII_like; PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to ...
      pfam04253
      Location:657772
      TFR_dimer; Transferrin receptor-like dimerization domain
      cl14876
      Location:93139
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
    2. XM_047426168.1XP_047282124.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X2

    3. XM_017017046.3XP_016872535.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X4

    4. XM_017017045.2XP_016872534.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X3

      Conserved Domains (4) summary
      cd08022
      Location:284531
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      cd02121
      Location:56282
      PA_GCPII_like; PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to ...
      pfam04253
      Location:568683
      TFR_dimer; Transferrin receptor-like dimerization domain
      cl14876
      Location:450
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    RNA

    1. XR_007062427.1 RNA Sequence

    2. XR_007062428.1 RNA Sequence

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_019805497.1 Reference GRCh38.p14 PATCHES

      Range
      37822..99017
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332422.1XP_054188397.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X1

    2. XM_054332423.1XP_054188398.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X2

    3. XM_054332425.1XP_054188400.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X4

    4. XM_054332424.1XP_054188399.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X3

    RNA

    1. XR_008485770.1 RNA Sequence

    2. XR_008485771.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      90051780..90112974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367343.1XP_054223318.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X1

    2. XM_054367344.1XP_054223319.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X2

    3. XM_054367346.1XP_054223321.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X4

    4. XM_054367345.1XP_054223320.1  N-acetylated-alpha-linked acidic dipeptidase 2 isoform X3

    RNA

    1. XR_008488319.1 RNA Sequence

    2. XR_008488320.1 RNA Sequence