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    ENOX2 ecto-NOX disulfide-thiol exchanger 2 [ Homo sapiens (human) ]

    Gene ID: 10495, updated on 5-Aug-2018

    Summary

    Official Symbol
    ENOX2provided by HGNC
    Official Full Name
    ecto-NOX disulfide-thiol exchanger 2provided by HGNC
    Primary source
    HGNC:HGNC:2259
    See related
    Ensembl:ENSG00000165675 MIM:300282; Vega:OTTHUMG00000022401
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APK1; tNOX; COVA1
    Summary
    This gene is a tumor-specific member of the ECTO-NOX family of genes that encode cell surface NADH oxidases. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The protein also displays prion-like properties. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
    Expression
    Ubiquitous expression in adrenal (RPKM 2.9), lymph node (RPKM 2.8) and 25 other tissues See more
    Orthologs

    Genomic context

    See ENOX2 in Genome Data Viewer
    Location:
    Xq26.1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (130622330..130903317, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (129757355..130037219, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373336 Neighboring gene GATA motif-containing MPRA enhancer 234 Neighboring gene chromosome 12 open reading frame 49 pseudogene Neighboring gene uncharacterized LOC105373338 Neighboring gene long intergenic non-protein coding RNA 1201 Neighboring gene Rho GTPase activating protein 36

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein disulfide oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    oxidation-reduction process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of growth IEA
    Inferred from Electronic Annotation
    more info
     
    ultradian rhythm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ecto-NOX disulfide-thiol exchanger 2
    Names
    APK1 antigen
    cytosolic ovarian carcinoma antigen 1
    ecto-NADPH oxidase disulfide-thiol exchanger 2
    tumor-associated NADH oxidase
    tumor-associated hydroquinone oxidase

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012562.1 RefSeqGene

      Range
      4918..284856
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001281736.1NP_001268665.1  ecto-NOX disulfide-thiol exchanger 2 isoform a

      See identical proteins and their annotated locations for NP_001268665.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 2. Variants 1 and 3 encode the same isoform (a) which is shorter at the N-terminus, compared to isoform b.
      Source sequence(s)
      AI540639, AK000353, BC108713, BC140874, DB128861
      Consensus CDS
      CCDS14627.1
      UniProtKB/Swiss-Prot
      Q16206
      UniProtKB/TrEMBL
      Q32ND0
      Related
      ENSP00000359973.1, OTTHUMP00000024021, ENST00000370935.5, OTTHUMT00000058276
      Conserved Domains (2) summary
      COG0724
      Location:90168
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12228
      Location:93176
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    2. NM_006375.3NP_006366.2  ecto-NOX disulfide-thiol exchanger 2 isoform a

      See identical proteins and their annotated locations for NP_006366.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and the 5' coding region and initiates translation at a downstream start codon, compared to variant 2. Variants 1 and 3 encode the same isoform (a) which is shorter at the N-terminus, compared to isoform b.
      Source sequence(s)
      AI540639, AK289837, BC140874, DB128861
      Consensus CDS
      CCDS14627.1
      UniProtKB/Swiss-Prot
      Q16206
      Related
      ENSP00000377890.1, ENST00000394363.5
      Conserved Domains (2) summary
      COG0724
      Location:90168
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12228
      Location:93176
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    3. NM_182314.2NP_872114.1  ecto-NOX disulfide-thiol exchanger 2 isoform b

      See identical proteins and their annotated locations for NP_872114.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longer isoform (b).
      Source sequence(s)
      AI540639, AK000353, AK289812, BC140874, DB128861
      Consensus CDS
      CCDS14626.1
      UniProtKB/Swiss-Prot
      Q16206
      Related
      ENSP00000337146.3, ENST00000338144.7
      Conserved Domains (2) summary
      COG0724
      Location:119197
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12228
      Location:122205
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

      Range
      130622330..130903317 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011531245.2XP_011529547.1  ecto-NOX disulfide-thiol exchanger 2 isoform X2

      Conserved Domains (2) summary
      COG0724
      Location:182260
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12228
      Location:185268
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    2. XM_017029229.2XP_016884718.1  ecto-NOX disulfide-thiol exchanger 2 isoform X5

    3. XM_011531244.3XP_011529546.1  ecto-NOX disulfide-thiol exchanger 2 isoform X1

      Conserved Domains (2) summary
      COG0724
      Location:182260
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12228
      Location:185268
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    4. XM_011531247.2XP_011529549.1  ecto-NOX disulfide-thiol exchanger 2 isoform X3

      See identical proteins and their annotated locations for XP_011529549.1

      UniProtKB/Swiss-Prot
      Q16206
      Conserved Domains (2) summary
      COG0724
      Location:119197
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12228
      Location:122205
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    5. XM_005262354.4XP_005262411.1  ecto-NOX disulfide-thiol exchanger 2 isoform X3

      See identical proteins and their annotated locations for XP_005262411.1

      UniProtKB/Swiss-Prot
      Q16206
      Conserved Domains (2) summary
      COG0724
      Location:119197
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12228
      Location:122205
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    6. XM_017029226.2XP_016884715.1  ecto-NOX disulfide-thiol exchanger 2 isoform X3

      UniProtKB/Swiss-Prot
      Q16206
      Conserved Domains (2) summary
      COG0724
      Location:119197
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12228
      Location:122205
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    7. XM_017029227.1XP_016884716.1  ecto-NOX disulfide-thiol exchanger 2 isoform X3

      UniProtKB/Swiss-Prot
      Q16206
      Conserved Domains (2) summary
      COG0724
      Location:119197
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12228
      Location:122205
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    8. XM_011531251.2XP_011529553.1  ecto-NOX disulfide-thiol exchanger 2 isoform X4

      See identical proteins and their annotated locations for XP_011529553.1

      UniProtKB/Swiss-Prot
      Q16206
      Conserved Domains (2) summary
      COG0724
      Location:90168
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12228
      Location:93176
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    9. XM_017029228.1XP_016884717.1  ecto-NOX disulfide-thiol exchanger 2 isoform X3

      UniProtKB/Swiss-Prot
      Q16206
      Conserved Domains (2) summary
      COG0724
      Location:119197
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12228
      Location:122205
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
    10. XM_011531249.2XP_011529551.1  ecto-NOX disulfide-thiol exchanger 2 isoform X3

      See identical proteins and their annotated locations for XP_011529551.1

      UniProtKB/Swiss-Prot
      Q16206
      Related
      ENSP00000359965.1, OTTHUMP00000024022, ENST00000370927.5, OTTHUMT00000058277
      Conserved Domains (2) summary
      COG0724
      Location:119197
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12228
      Location:122205
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
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