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ITGB3 integrin subunit beta 3 [ Homo sapiens (human) ]

Gene ID: 3690, updated on 3-Mar-2026

Summary

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Official Symbol: ITGB3provided by HGNC
Official Full Name: integrin subunit beta 3provided by HGNC
Primary source: HGNC:HGNC:6156
See related: Ensembl:ENSG00000259207 MIM:173470; AllianceGenome:HGNC:6156
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GT; GT2; CD61; GP3A; BDPLT2; FMAIT1; GPIIIa; BDPLT16; BDPLT24
Summary: The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
Expression: Broad expression in thyroid (RPKM 33.0), endometrium (RPKM 10.1) and 14 other tissues See more
Orthologs: all
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Genomic context

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See ITGB3 in Genome Data Viewer

Location:: 17q21.32

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (47253827..47313743)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (48116181..48176126)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (45331193..45391109)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Acute contact with profibrotic macrophages mechanically activates fibroblasts via alphavbeta3 integrin-mediated engagement of Piezo1.
Title: Acute contact with profibrotic macrophages mechanically activates fibroblasts via αvβ3 integrin-mediated engagement of Piezo1.
Role of TSP-1 and its receptor ITGB3 in the renal tubulointerstitial injury of focal segmental glomerulosclerosis.
Title: Role of TSP-1 and its receptor ITGB3 in the renal tubulointerstitial injury of focal segmental glomerulosclerosis.
The Role of alphavbeta3 Integrin in Lamina Cribrosa Cell Mechanotransduction in Glaucoma.
Title: The Role of αvβ3 Integrin in Lamina Cribrosa Cell Mechanotransduction in Glaucoma.
Targeting ITGbeta3 to Overcome Trastuzumab Resistance through Epithelial-Mesenchymal Transition Regulation in HER2-Positive Breast Cancer.
Title: Targeting ITGβ3 to Overcome Trastuzumab Resistance through Epithelial-Mesenchymal Transition Regulation in HER2-Positive Breast Cancer.
Full-length alphaIIbbeta3 cryo-EM structure reveals intact integrin initiate-activation intrinsic architecture.
Title: Full-length αIIbβ3 cryo-EM structure reveals intact integrin initiate-activation intrinsic architecture.
Integrin alphavbeta3 Upregulation in Response to Nutrient Stress Promotes Lung Cancer Cell Metabolic Plasticity.
Title: Integrin αvβ3 Upregulation in Response to Nutrient Stress Promotes Lung Cancer Cell Metabolic Plasticity.
Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity.
Title: Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity.
Endometrial BMP2 Deficiency Impairs ITGB3-Mediated Trophoblast Invasion in Women With Repeated Implantation Failure.
Title: Endometrial BMP2 Deficiency Impairs ITGB3-Mediated Trophoblast Invasion in Women With Repeated Implantation Failure.
The role of thrombomodulin in modulating ITGB3 expression and its implications for triple-negative breast cancer progression.
Title: The role of thrombomodulin in modulating ITGB3 expression and its implications for triple-negative breast cancer progression.
Integrin-alphavbeta3 is a Therapeutically Targetable Fundamental Factor in Medulloblastoma Tumorigenicity and Radioresistance.
Title: Integrin-αvβ3 is a Therapeutically Targetable Fundamental Factor in Medulloblastoma Tumorigenicity and Radioresistance.

Submit: New GeneRIF Correction See all GeneRIFs (824)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Bleeding disorder, platelet-type, 24 MedGen: C5543280 OMIM: 619271 GeneReviews: Not available	Compare labs
FETOMATERNAL ALLOIMMUNE THROMBOCYTOPENIA 1 MedGen: C1868202 OMIM: 621264 GeneReviews: Not available	not available
Glanzmann thrombasthenia 2 MedGen: C5543273 OMIM: 619267 GeneReviews: Not available	not available

Copy number response

Description
Copy number response Haploinsufficency No evidence available (Last evaluated 2012-08-27) ClinGen Genome Curation Page Triplosensitivity No evidence available (Last evaluated 2012-08-27) ClinGen Genome Curation Page

EBI GWAS Catalog

Description
Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids. EBI GWAS Catalog EBI GWAS CatalogPubMed
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 Tat complexes with gp120 to induce entry of VLPs expressing R5- or X4-tropic Env into MDDCs, which involves alpha5beta1, alpha5beta3, and alpha5beta5 integrins	PubMed
Tat	tat	HIV-1 Tat-induced inhibition of IFN-gamma release is regulated by the interaction of Tat-RGD domain with alpha5beta1 and alpha5beta3 integrins in CD8+ T cells	PubMed
	tat	HIV-1 Tat complexes with gp120 to induce entry of VLPs expressing R5- or X4-tropic Env into MDDCs, which involves alpha5beta1, alpha5beta3, and alpha5beta5 integrins	PubMed
	tat	Endothelial cell adherent to HIV-1 Tat induces upregulation of VEGFR2, integrin beta(3) subunit, and pp60src and recruits VEGFR2, integrin beta(3) subunit, paxillin, focal adhesion kinase, and pp60src to ventral plasma membranes	PubMed
	tat	Endothelial cell adherent to HIV-1 Tat induces rearrangement of actin cytoskeleton and is dependent on integrin alpha5beta3	PubMed
	tat	Sialic acid is required for signal transduction triggered by HIV-1 Tat/integrin alpha5beta3 interaction in endothelial cells	PubMed
	tat	Sialic acid (NeuAc)-binding lectin from Maakia amurensis binds the NeuAc residues of integrin alpha5beta3 and inhibits the interaction of the integrin with the basic domain of HIV-1 Tat	PubMed
	tat	HIV-1 Tat-induced platelet activation requires the chemokine receptor CCR3 and beta3-integrin expression on platelets and calcium flux in platelets	PubMed
	tat	HIV-1 Tat-mediated inhibition of autophagy in bystander macrophages/monocytic cells requires CXCR4, VEGFR1, and beta-integrins	PubMed
	tat	The arginine-glycine-aspartic acid (RGD) sequence present at the carboxy-terminal of HIV-1 Tat mediates vascular cell and monocyte migration and invasion by binding to the alpha-5-beta-1 and alpha-v-beta-3 integrins	PubMed
	tat	HIV-1 Tat induced monocyte invasion is inhibited by anti-beta integrin Ab or tissue inhibitor of metalloproteinase (TIMP), indicating an interaction with beta integrins and TIMP	PubMed
	tat	HIV-1 Tat upregulates the levels of CD61 in phorbol myristate acetate (PMA)-stimulated K562 hematopoietic progenitor cells	PubMed
	tat	HIV-1 Tat exerts several pleiotropic effects by interacting with different cellular receptors, including integrin alpha(v)beta3, which triggers the activation of focal adhesion kinase, RhoA and pp60src	PubMed
	tat	IFN-gamma interacts with HIV-1 Tat to induce endothelial cells to proliferate and invade the extracellular matrix by upregulating the receptors for Tat (integrins alpha-5-beta-1 and alpha-v-beta-3), suggesting Tat and IFN-gamma play major roles in AIDS-KS	PubMed
	tat	The RGD-containing domain of exogenous HIV-1 Tat inhibits the engulfment of apoptotic bodies by dendritic cells through an interaction with integrin alpha v beta 3	PubMed
	tat	HIV-1 Tat induces angiogenesis and cooperates in the development of AIDS-associated Kaposi sarcoma as a result of interactions with integrins alpha-5-beta-1 and alpha-v-beta 3	PubMed
nucleocapsid	gag	HIV-1 NC upregulates integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) in HEK 293T cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-S70348 (e-PCR)
- UniSTS:15116

Itgb3 (e-PCR), detects polymorphism
- UniSTS:143631

STS-R30939 (e-PCR)
- UniSTS:25144

Itgb3 (e-PCR), detects polymorphism
- UniSTS:497470

D17S1991 (e-PCR)
- UniSTS:74344

G10641 (e-PCR)
- UniSTS:53104

SHGC-35279 (e-PCR)
- UniSTS:70262

RH47114 (e-PCR)
- UniSTS:52347

STS-AA037229 (e-PCR)
- UniSTS:40586

D16S325 (e-PCR)
- UniSTS:147089

GDB:187323 (e-PCR)
- UniSTS:155543

SHGC-144857 (e-PCR)
- UniSTS:172465

D17S660 (e-PCR)
- UniSTS:22731

STS-M35999 (e-PCR)
- UniSTS:73717

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
contributes_to C-X3-C chemokine binding	IDA Inferred from Direct Assay more info	PubMed
enables cell adhesion molecule binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to cell adhesion receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables coreceptor activity	IEA Inferred from Electronic Annotation more info
enables coreceptor activity	TAS Traceable Author Statement more info	PubMed
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables extracellular matrix binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to fibrinogen binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to fibrinogen binding	IEA Inferred from Electronic Annotation more info
contributes_to fibroblast growth factor binding	IDA Inferred from Direct Assay more info	PubMed
enables fibronectin binding	IBA Inferred from Biological aspect of Ancestor more info
enables fibronectin binding	IEA Inferred from Electronic Annotation more info
enables fibronectin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to insulin-like growth factor I binding	IDA Inferred from Direct Assay more info	PubMed
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
contributes_to neuregulin binding	IDA Inferred from Direct Assay more info	PubMed
enables platelet-derived growth factor receptor binding	TAS Traceable Author Statement more info	PubMed
enables protease binding	IDA Inferred from Direct Assay more info	PubMed
enables protease binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein disulfide isomerase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase C binding	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor receptor 2 binding	IPI Inferred from Physical Interaction more info	PubMed
enables vascular endothelial growth factor receptor 2 binding	TAS Traceable Author Statement more info	PubMed
enables virus receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in angiogenesis involved in wound healing	TAS Traceable Author Statement more info	PubMed
involved_in apolipoprotein A-I-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic cell clearance	IEA Inferred from Electronic Annotation more info
involved_in apoptotic cell clearance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in blood coagulation	TAS Traceable Author Statement more info	PubMed
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	TAS Traceable Author Statement more info	PubMed
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion mediated by integrin	IDA Inferred from Direct Assay more info	PubMed
involved_in cell adhesion mediated by integrin	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion mediated by integrin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion mediated by integrin	IDA Inferred from Direct Assay more info	PubMed
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-matrix adhesion	NAS Non-traceable Author Statement more info	PubMed
involved_in cell-substrate adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to insulin-like growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in embryo implantation	IEA Inferred from Electronic Annotation more info
involved_in heterotypic cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in heterotypic cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in heterotypic cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in integrin-mediated signaling pathway	HDA more info	PubMed
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in integrin-mediated signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in integrin-mediated signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in maintenance of postsynaptic specialization structure	IEA Inferred from Electronic Annotation more info
involved_in mesodermal cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in mesodermal cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of endothelial cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of lipid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of lipoprotein metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of low-density lipoprotein particle clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of macrophage derived foam cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in platelet activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in platelet aggregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in platelet aggregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of bone resorption	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell adhesion mediated by integrin	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fibroblast migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of glomerular mesangial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of leukocyte migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of osteoblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smooth muscle cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular endothelial growth factor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of bone resorption	IEA Inferred from Electronic Annotation more info
involved_in regulation of bone resorption	TAS Traceable Author Statement more info	PubMed
involved_in regulation of developmental process	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynaptic neurotransmitter receptor diffusion trapping	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynaptic neurotransmitter receptor internalization	EXP Inferred from Experiment more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of release of sequestered calcium ion into cytosol	IEA Inferred from Electronic Annotation more info
involved_in regulation of serotonin uptake	IEA Inferred from Electronic Annotation more info
involved_in regulation of serotonin uptake	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transport	IEA Inferred from Electronic Annotation more info
involved_in response to activity	IEA Inferred from Electronic Annotation more info
involved_in response to platelet-derived growth factor	IEA Inferred from Electronic Annotation more info
involved_in smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in substrate adhesion-dependent cell spreading	IDA Inferred from Direct Assay more info	PubMed
involved_in symbiont entry into host cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tube development	TAS Traceable Author Statement more info	PubMed
involved_in wound healing	IC Inferred by Curator more info	PubMed
involved_in wound healing, spreading of epidermal cells	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of alpha9-beta1 integrin-ADAM8 complex	IEA Inferred from Electronic Annotation more info
part_of alphav-beta3 integrin-HMGB1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of alphav-beta3 integrin-IGF-1-IGF1R complex	IDA Inferred from Direct Assay more info	PubMed
part_of alphav-beta3 integrin-PKCalpha complex	IDA Inferred from Direct Assay more info	PubMed
part_of alphav-beta3 integrin-PKCalpha complex	IEA Inferred from Electronic Annotation more info
part_of alphav-beta3 integrin-vitronectin complex	TAS Traceable Author Statement more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cell surface	HDA more info	PubMed
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	HDA more info	PubMed
located_in filopodium	IEA Inferred from Electronic Annotation more info
located_in filopodium membrane	IDA Inferred from Direct Assay more info	PubMed
located_in focal adhesion	HDA more info	PubMed
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glycinergic synapse	IEA Inferred from Electronic Annotation more info
part_of integrin alphaIIb-beta3 complex	IDA Inferred from Direct Assay more info	PubMed
part_of integrin alphav-beta3 complex	IDA Inferred from Direct Assay more info	PubMed
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	IDA Inferred from Direct Assay more info	PubMed
part_of integrin complex	IEA Inferred from Electronic Annotation more info
part_of integrin complex	TAS Traceable Author Statement more info	PubMed
located_in lamellipodium membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium membrane	IEA Inferred from Electronic Annotation more info
located_in melanosome	IDA Inferred from Direct Assay more info	PubMed
located_in microvillus membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in platelet alpha granule membrane	TAS Traceable Author Statement more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle	IEA Inferred from Electronic Annotation more info
located_in ruffle membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synapse	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synaptic membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: integrin beta-3

Names: antigen CD61; integrin beta 3; integrin beta chain, beta 3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); platelet membrane glycoprotein IIIa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_008332.2 RefSeqGene

Range

5001..63870

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_481

mRNA and Protein(s)

NM_000212.3 → NP_000203.2 integrin beta-3 precursor

See identical proteins and their annotated locations for NP_000203.2

Status: REVIEWED

Source sequence(s)

AC068234, M35999

Consensus CDS

CCDS11511.1

UniProtKB/Swiss-Prot

A0PJW2, D3DXJ8, O15495, P05106, Q12806, Q13413, Q14648, Q16499

UniProtKB/TrEMBL

A0A5E4DMZ9, L7UUZ7

Related

ENSP00000452786.2, ENST00000559488.7

Conserved Domains (3) summary

pfam00362
Location:38 → 461

Integrin_beta; Integrin, beta chain

pfam07965
Location:634 → 717

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:744 → 786

Integrin_b_cyt; Integrin beta cytoplasmic domain