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    TP53 tumor protein p53 [ Homo sapiens (human) ]

    Gene ID: 7157, updated on 25-Oct-2020

    Summary

    Official Symbol
    TP53provided by HGNC
    Official Full Name
    tumor protein p53provided by HGNC
    Primary source
    HGNC:HGNC:11998
    See related
    Ensembl:ENSG00000141510 MIM:191170
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P53; BCC7; LFS1; BMFS5; TRP53
    Summary
    This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
    Expression
    Ubiquitous expression in spleen (RPKM 13.2), lymph node (RPKM 13.1) and 25 other tissues See more
    Orthologs

    Genomic context

    See TP53 in Genome Data Viewer
    Location:
    17p13.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109.20200815 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (7668402..7687550, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7571720..7590868, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene sex hormone binding globulin Neighboring gene spermidine/spermine N1-acetyltransferase family member 2 Neighboring gene ATPase Na+/K+ transporting subunit beta 2 Neighboring gene WD repeat containing antisense to TP53 Neighboring gene ephrin B3 Neighboring gene dynein axonemal heavy chain 2 Neighboring gene ribosomal protein L29 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Professional guidelines

    Description
    Professional guideline
    ACMG 2013

    The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in TP53 that are pathogenic or expected to be pathogenic.

    GuidelinePubMed

    Associated conditions

    Description Tests
    A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
    GeneReviews: Not available
    A germline variant in the TP53 polyadenylation signal confers cancer susceptibility.
    GeneReviews: Not available
    Adrenocortical carcinoma, hereditary
    MedGen: C1859972 OMIM: 202300 GeneReviews: Not available
    Compare labs
    Basal cell carcinoma, susceptibility to, 7
    MedGen: C3553606 OMIM: 614740 GeneReviews: Not available
    Compare labs
    BONE MARROW FAILURE SYNDROME 5
    MedGen: C4748488 OMIM: 618165 GeneReviews: Not available
    Compare labs
    Carcinoma of pancreas
    MedGen: C0235974 OMIM: 260350 GeneReviews: Not available
    Compare labs
    Choroid plexus papilloma
    MedGen: C0205770 OMIM: 260500 GeneReviews: Not available
    Compare labs
    Colorectal cancer
    MedGen: C1527249 OMIM: 114500 GeneReviews: Lynch Syndrome
    Compare labs
    Familial cancer of breast Compare labs
    Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma.
    GeneReviews: Not available
    Glioma susceptibility 1
    MedGen: C2750850 OMIM: 137800 GeneReviews: Not available
    Compare labs
    Hepatocellular carcinoma
    MedGen: C2239176 OMIM: 114550 GeneReviews: Not available
    Compare labs
    Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.
    GeneReviews: Not available
    Li-Fraumeni syndrome 1 Compare labs
    Nasopharyngeal carcinoma
    MedGen: C2931822 OMIM: 607107 GeneReviews: Not available
    Compare labs
    Osteosarcoma
    MedGen: C0029463 OMIM: 259500 GeneReviews: Not available
    Compare labs

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated (2016-09-08)

    ClinGen Genome Curation Page
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated (2016-09-08)

    ClinGen Genome Curation PagePubMed

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Latent HIV infection increases TP53 (p53) expression and phosphorylation PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 Env gp120 induces TP53 (p53) via binding to the CXCR4 co-receptor PubMed
    env HIV-1 Env gp120 treatment activates TP53 (p53) which contributes to the upregulation of the mitochondrial redox enzyme PRODH (POX) PubMed
    env HIV-1 gp120 is potentially cytotoxic to human cells through the induction of p53, which may eventually lead to induction of apoptosis PubMed
    env Caspase 8 proteolytic target protein Bid is cleaved and undergoes mitochondrial translocation in gp120-treated p53 expression neurons PubMed
    env HIV-1 gp120-mediated activation of caspase 8 occurs in a p53 independent manner, while HIV-1 gp120-mediated activation of caspase 3 requires p53 PubMed
    env Tumor suppressor protein PML is required for the activating phosphorylation of ATM, p38 MAPK, and p53 in HIV-1 Env-elicited syncytia PubMed
    env p38 MAPK-mediated p53 phosphorylation on serine 46 contributes to apoptosis induced by the HIV-1 envelope glycoprotein complex (gp120/gp41) PubMed
    env Syncytial apoptosis mediated by the fusion of cells expressing HIV-1 gp120 with cells expressing the CD4/CXCR4 receptor/coreceptor complex causes phosphorylation of p53 on serine 15 and Bax upregulation PubMed
    Nef nef Assays with phage-displayed Nef from HIV-1 NL4-3 have been used to identify a series of guanidine alkaloid-based inhibitors of Nef interactions with p53, actin, and p56(lck) PubMed
    nef HIV-1 Nef binds directly to tumor suppressor protein p53; an N-terminal 57-residue fragment of Nef (Nef 1-57) contains the p53-binding domain PubMed
    Pr55(Gag) gag HIV-1 infection upregulates the expression of p53 in CD4+ T cells and PBMCs in terms of increased cellular HIV-1 Gag/p24 levels PubMed
    Rev rev HIV-1 Tat reactivates latent HIV-1 proviruses in J1.1 and ACH-2 cell lines and promotes p53-induced apoptosis in the presence of Rev PubMed
    Tat tat Expression of p53 inhibits HIV-1 Tat activity in a dose-dependent manner and PKR plays a crucial role in p53-mediated Tat suppression in p53-/- cells PubMed
    tat Wild-type p53 is a potent inhibitor of HIV-1 Tat transactivation of the HIV-1 LTR promoter in Jurkat T cells and Hep3B cells PubMed
    tat HIV-1 Tat downregulates the expression of p53, suggesting a mechanism for HIV-1-mediated transformation of infected cells PubMed
    tat Treatment with HIV-Tat and morphine activates extracellular signal-regulated kinase-1/2 (ERK1/2), upregulates p53 and p21 levels, and downregulates cyclin D1 and Akt levels in human fetal brain-derived neural precursor cells PubMed
    tat HIV-1 Tat activates the p53 transcription factor pathway leading to the induction of endogenous p53 and p73 in neuronal cells PubMed
    tat HIV-1 Tat inhibits SIRT1 and increases acetylation of p53, which leads to activation of p21 and BAX in HeLa-CD4+ cells PubMed
    tat When expressed in astrocytes, neurons, and non-glial 293T cells, HIV-1 Tat interacts with a number of cell cycle-related proteins including cyclin A, cyclin B, cyclin D3, Cdk2, Cdk4, Cdk1/Cdc2, cdc6, p27, p53, p63, hdlg, and PCNA PubMed
    tat HIV-1 Tat reactivates latent HIV-1 proviruses in J1.1 and ACH-2 cell lines and promotes p53-induced apoptosis in the presence of Rev PubMed
    tat The p53 tetramerization domain (residues 326-355) binds directly to residues 1-35 and 47-57 in HIV-1 Tat as evidenced by using peptide mapping, fluorescence anisotropy, and NMR spectroscopy PubMed
    tat In the absence of either p53 or p73, Tat fails to induce dendritic retraction or to activate the proapoptotic proteins, such as Bax PubMed
    tat Activation of p38 MAPK in HIV-infected cells mediated by Tat leads to the phosphorylation of p53 which subsequently upregulates CAV-1 expression PubMed
    tat HIV-1 Tat binds to p53, an interaction mediated by the basic region of Tat (amino acids 49-57) and the acidic O2 domain of p53 (amino acids 341-354 PubMed
    tat Supernatants from HIV-1 Tat-transfected monocytoid cells induces p53 expression in neurons, indicating a role for Tat in the neuropathogenesis of HIV-1 PubMed
    tat HIV-1 Tat inhibits p53-responsive transcription by binding to histone acetyltransferases and repressing the acetylation of p53 on residue Lys-320, alluding to a mechanism whereby Tat may impair p53 functions, thus favoring the establishment of neoplasia PubMed
    tat HIV-1 Tat and p53 cooperate in the activation of HIV-1 gene expression in SaOS2 cells PubMed
    Vif vif HIV-1 Vif stabilizes TP53 by blocking MDM2-induced ubiquitination and inhibits MDM2-mediated nuclear export of TP53, leading to support viral replication through inducing G2 cell cycle arrest PubMed
    vif The N-terminal region (residues 1-50) of HIV-1 Vif is important for binding to TP53 PubMed
    Vpr vpr HIV-1 Vpr interacts with p53 in a complex with the transcription factor Sp1 that modulates viral gene transcription from the HIV-1 LTR promoter PubMed
    vpr HIV-1 Vpr downregulates proliferation-associated protein 2G4 (PA2G4) and upregulates p53 in glioblastoma U87MG cells PubMed
    vpr Exposure of cultured human primary astrocytes to HIV-1 Vpr induces p53 up-regulation, loss of mitochondrial membrane potential, and caspase-6 activation followed by cell injury PubMed
    vpr Soluble HIV-1 Vpr causes neuronal apoptosis, involving cytochrome c extravasation, p53 induction, and activation of caspase-9 PubMed
    vpr HIV-1 Vpr inhibits the interaction of p53 and Rad51 in chromatin fractions, as observed under irradiation-induced DNA double-strand breaks PubMed
    vpr Results from GST pull-down assays show the association of Vpr with p53 in extracts containing Sp1, suggesting the physical interaction of Vpr with Sp1 and p53 could modulate transcriptional activity of p21 PubMed
    vpr Activation of p21/Waf1/Cip1 by HIV-1 Vpr appears to be regulated by p53 PubMed
    vpr HIV-1 Vpr can neutralize inhibitory effects of the human homologue of yeast Rad23 protein A (hHR23A) on p53, thereby activating p53 transcriptional activity PubMed
    vpr Overexpression of p53 decreases the level of activation of the viral LTR promoter by HIV-1 Vpr PubMed
    Vpu vpu HIV-1 Vpu expression results in significant upregulation of phosphorylated p53. Vpu contributes to p53-dependent apoptosis in HIV-1-infected cells PubMed
    vpu HIV-1 Vpu expression leads to stabilization and upregulation of p53 via inhibiting association of p53 with beta-TrCP and its subsequent ubiquitination PubMed
    integrase gag-pol HIV-1 IN-mediated proviral DNA integration triggers cell death during HIV-1 infection. The mechanism of killing during viral integration involves activation of DNA-PK, which causes phosphorylation of p53 and histone gammaH2AX PubMed
    reverse transcriptase gag-pol Tumor suppressor protein p53 displays 3' --> 5' exonuclease activity, and interaction of p53 with HIV-1 reverse transcriptase (RT) can provide a proofreading function for HIV-1 RT PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ92943

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    DNA-binding transcription factor activity, RNA polymerase II-specific ISM
    Inferred from Sequence Model
    more info
    PubMed 
    MDM2/MDM4 family protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II proximal promoter sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    RNA polymerase II transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    TFIID-class transcription factor complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    chaperone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    copper ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    disordered domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    histone acetyltransferase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    histone deacetylase regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    p53 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein N-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein phosphatase 2A binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein self-association IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    zinc ion binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    B cell lineage commitment IEA
    Inferred from Electronic Annotation
    more info
     
    DNA damage response, signal transduction by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA damage response, signal transduction by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
    Traceable Author Statement
    more info
     
    DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA strand renaturation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ER overload response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Ras protein signal transduction IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    T cell differentiation in thymus IEA
    Inferred from Electronic Annotation
    more info
     
    T cell lineage commitment IEA
    Inferred from Electronic Annotation
    more info
     
    T cell proliferation involved in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    bone marrow development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac septum morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cell aging IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell cycle arrest IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell cycle arrest IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to DNA damage stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to UV IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to UV-C IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to actinomycin D IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to gamma radiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to glucose starvation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to ionizing radiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cerebellum development IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    circadian behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    determination of adult lifespan ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    double-strand break repair IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic organ development IEA
    Inferred from Electronic Annotation
    more info
     
    entrainment of circadian clock by photoperiod ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    gastrulation IEA
    Inferred from Electronic Annotation
    more info
     
    hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hematopoietic stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    interferon-gamma-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    intrinsic apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    intrinsic apoptotic signaling pathway by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
    Inferred from Electronic Annotation
    more info
     
    intrinsic apoptotic signaling pathway in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrial DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic G1 DNA damage checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic cell cycle arrest IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    necroptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of glucose catabolic process to lactate via pyruvate IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of helicase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of mitophagy IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of pentose-phosphate shunt IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of production of miRNAs involved in gene silencing by miRNA IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of reactive oxygen species metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of telomerase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oligodendrocyte apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidative stress-induced premature senescence IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of RNA polymerase II transcriptional preinitiation complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cardiac muscle cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell aging IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell cycle arrest IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell cycle arrest IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell cycle arrest IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of execution phase of apoptosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of histone deacetylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of intrinsic apoptotic signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of mitochondrial membrane permeability IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of pri-miRNA transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of pri-miRNA transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of production of miRNAs involved in gene silencing by miRNA IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein export from nucleus TAS
    Traceable Author Statement
    more info
     
    positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
     
    positive regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of release of cytochrome c from mitochondria IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of thymocyte apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription from RNA polymerase II promoter in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter in response to stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein deubiquitination TAS
    Traceable Author Statement
    more info
     
    protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein stabilization IEA
    Inferred from Electronic Annotation
    more info
     
    protein tetramerization IEA
    Inferred from Electronic Annotation
    more info
     
    protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    rRNA transcription IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of DNA damage response, signal transduction by p53 class mediator IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of apoptotic process TAS
    Traceable Author Statement
    more info
     
    regulation of cell cycle G2/M phase transition TAS
    Traceable Author Statement
    more info
     
    regulation of cellular senescence IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of fibroblast apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of intrinsic apoptotic signaling pathway by p53 class mediator IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of mitochondrial membrane permeability involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of signal transduction by p53 class mediator TAS
    Traceable Author Statement
    more info
     
    regulation of tissue remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription from RNA polymerase II promoter in response to DNA damage IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    release of cytochrome c from mitochondria IEA
    Inferred from Electronic Annotation
    more info
     
    replicative senescence IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to X-ray IEA
    Inferred from Electronic Annotation
    more info
     
    response to antibiotic IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to gamma radiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to ischemia IEA
    Inferred from Electronic Annotation
    more info
     
    response to salt stress IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    PubMed 
    somitogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    tumor necrosis factor-mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    viral process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    PML body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with nuclear body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromatin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nuclear chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    nuclear matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear membrane IDA
    Inferred from Direct Assay
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-containing complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    replication fork IEA
    Inferred from Electronic Annotation
    more info
     
    site of double-strand break IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with transcription factor TFIID complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor complex IGI
    Inferred from Genetic Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    cellular tumor antigen p53
    Names
    antigen NY-CO-13
    mutant tumor protein 53
    p53 tumor suppressor
    phosphoprotein p53
    transformation-related protein 53
    tumor protein 53
    tumor supressor p53

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_017013.2 RefSeqGene

      Range
      5001..24149
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_321

    mRNA and Protein(s)

    1. NM_000546.6NP_000537.3  cellular tumor antigen p53 isoform a

      See identical proteins and their annotated locations for NP_000537.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (a, also known as p53alpha) results from translation initiation at the upstream start codon. Both variants 1 and 2 encode isoform a, which is the longest isoform.
      Source sequence(s)
      AK223026, DA453049, X02469
      Consensus CDS
      CCDS11118.1
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      K7PPA8, Q53GA5
      Related
      ENSP00000269305.4, ENST00000269305.8
      Conserved Domains (4) summary
      cd08367
      Location:109288
      P53; P53 DNA-binding domain
      pfam07710
      Location:319355
      P53_tetramer; P53 tetramerisation motif
      pfam08563
      Location:630
      P53_TAD; P53 transactivation motif
      pfam18521
      Location:3559
      TAD2; Transactivation domain 2
    2. NM_001126112.3NP_001119584.1  cellular tumor antigen p53 isoform a

      See identical proteins and their annotated locations for NP_001119584.1

      Status: REVIEWED

      Source sequence(s)
      AC007421, AC087388
      Consensus CDS
      CCDS11118.1
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      K7PPA8, Q53GA5
      Related
      ENSP00000391478.2, ENST00000445888.6
      Conserved Domains (4) summary
      cd08367
      Location:109288
      P53; P53 DNA-binding domain
      pfam07710
      Location:319355
      P53_tetramer; P53 tetramerisation motif
      pfam08563
      Location:630
      P53_TAD; P53 transactivation motif
      pfam18521
      Location:3559
      TAD2; Transactivation domain 2
    3. NM_001126113.3NP_001119585.1  cellular tumor antigen p53 isoform c

      See identical proteins and their annotated locations for NP_001119585.1

      Status: REVIEWED

      Source sequence(s)
      AC007421, AC087388
      Consensus CDS
      CCDS45605.1
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      Q53GA5
      Related
      ENSP00000398846.2, ENST00000455263.6
      Conserved Domains (2) summary
      pfam00870
      Location:95289
      P53; P53 DNA-binding domain
      pfam08563
      Location:528
      P53_TAD; P53 transactivation motif
    4. NM_001126114.3NP_001119586.1  cellular tumor antigen p53 isoform b

      See identical proteins and their annotated locations for NP_001119586.1

      Status: REVIEWED

      Source sequence(s)
      AC007421, AC087388
      Consensus CDS
      CCDS45606.1
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      Q53GA5
      Related
      ENSP00000391127.2, ENST00000420246.6
      Conserved Domains (2) summary
      pfam00870
      Location:95289
      P53; P53 DNA-binding domain
      pfam08563
      Location:528
      P53_TAD; P53 transactivation motif
    5. NM_001126115.2NP_001119587.1  cellular tumor antigen p53 isoform d

      See identical proteins and their annotated locations for NP_001119587.1

      Status: REVIEWED

      Source sequence(s)
      AC007421, AC087388
      Consensus CDS
      CCDS73966.1
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      Q53GA5
      Related
      ENSP00000481179.1, ENST00000504937.5
      Conserved Domains (2) summary
      pfam07710
      Location:187226
      P53_tetramer; P53 tetramerization motif
      cl14608
      Location:1157
      P53; P53 DNA-binding domain
    6. NM_001126116.2NP_001119588.1  cellular tumor antigen p53 isoform e

      See identical proteins and their annotated locations for NP_001119588.1

      Status: REVIEWED

      Source sequence(s)
      AC007421, AC087388
      Consensus CDS
      CCDS73968.1
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      Q53GA5
      Related
      ENSP00000478499.1, ENST00000510385.5
      Conserved Domains (1) summary
      cl14608
      Location:1157
      P53; P53 DNA-binding domain
    7. NM_001126117.2NP_001119589.1  cellular tumor antigen p53 isoform f

      See identical proteins and their annotated locations for NP_001119589.1

      Status: REVIEWED

      Source sequence(s)
      AC007421, AC087388
      Consensus CDS
      CCDS73967.1
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      Q53GA5
      Related
      ENSP00000484409.1, ENST00000504290.5
      Conserved Domains (1) summary
      cl14608
      Location:1157
      P53; P53 DNA-binding domain
    8. NM_001126118.2NP_001119590.1  cellular tumor antigen p53 isoform g

      See identical proteins and their annotated locations for NP_001119590.1

      Status: REVIEWED

      Source sequence(s)
      AC007421, AC087388
      Consensus CDS
      CCDS73969.1
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      H2EHT1, Q53GA5
      Related
      ENSP00000478219.1, ENST00000610292.4
      Conserved Domains (2) summary
      pfam00870
      Location:56250
      P53; P53 DNA-binding domain
      pfam07710
      Location:280319
      P53_tetramer; P53 tetramerisation motif
    9. NM_001276695.3NP_001263624.1  cellular tumor antigen p53 isoform h

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an additional exon in the 3' coding region, resulting in an alternate 3' coding region and 3' UTR, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (h, also known as delta40p53gamma) results from translation initiation at the downstream start codon. It has a shorter N-terminus and a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK223026, DA453049, DQ186649
      Consensus CDS
      CCDS73970.1
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      Q53GA5
      Related
      ENSP00000480868.1, ENST00000610538.4
      Conserved Domains (1) summary
      pfam00870
      Location:56250
      P53; P53 DNA-binding domain
    10. NM_001276696.3NP_001263625.1  cellular tumor antigen p53 isoform i

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an additional exon in the 3' region, resulting in an alternate 3' coding region and 3' UTR, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (i, also known as delta40p53beta) results from translation initiation at the downstream start codon. It has a shorter N-terminus and a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK223026, DA453049, DQ186648, DQ186649
      Consensus CDS
      CCDS73971.1
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      Q53GA5
      Related
      ENSP00000482222.1, ENST00000622645.4
      Conserved Domains (1) summary
      pfam00870
      Location:56250
      P53; P53 DNA-binding domain
    11. NM_001276697.3NP_001263626.1  cellular tumor antigen p53 isoform j

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate promoter and lacks multiple 5' exons, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (j, also known as delta160p53alpha) results from translation initiation at the downstream start codon. It has a shorter N-terminus, compared to isoform a. This variant is supported by data in PMID:16131611.
      Source sequence(s)
      AK223026, DQ186650
      Consensus CDS
      CCDS73963.1
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      A0A087X1Q1, Q53GA5
      Conserved Domains (2) summary
      pfam07710
      Location:160199
      P53_tetramer; P53 tetramerisation motif
      cl14608
      Location:1130
      P53; P53 DNA-binding domain
    12. NM_001276698.3NP_001263627.1  cellular tumor antigen p53 isoform k

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate promoter and lacks multiple 5' exons, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (k, also known as delta160p53beta) results from translation initiation at the downstream start codon. It has a shorter N-terminus and a distinct C-terminus, compared to isoform a. This variant is supported by data in PMID:16131611.
      Source sequence(s)
      AK223026, DQ186651
      Consensus CDS
      CCDS73965.1
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      A0A087WXZ1, Q53GA5
      Related
      ENSP00000481401.1, ENST00000618944.4
      Conserved Domains (1) summary
      cl14608
      Location:1130
      P53; P53 DNA-binding domain
    13. NM_001276699.3NP_001263628.1  cellular tumor antigen p53 isoform l

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) uses an alternate promoter and lacks multiple 5' exons, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (l, also known as delta160p53gamma) results from translation initiation at the downstream start codon. It has a shorter N-terminus and a distinct C-terminus, compared to isoform a. This variant is supported by data in PMID:16131611.
      Source sequence(s)
      AK223026, DQ186652
      Consensus CDS
      CCDS73964.1
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      A0A087WT22, Q53GA5
      Related
      ENSP00000477531.1, ENST00000610623.4
      Conserved Domains (1) summary
      cl14608
      Location:1130
      P53; P53 DNA-binding domain
    14. NM_001276760.3NP_001263689.1  cellular tumor antigen p53 isoform g

      See identical proteins and their annotated locations for NP_001263689.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (g, also known as delta40p53alpha or deltaNp53) results from translation initiation at the downstream start codon. It has a shorter N-terminus, compared to isoform a. Variants 1, 2, and 8 encode isoform g.
      Source sequence(s)
      AK223026, DA453049, X02469
      Consensus CDS
      CCDS73969.1
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      H2EHT1, Q53GA5
      Related
      ENSP00000481638.1, ENST00000620739.4
      Conserved Domains (2) summary
      pfam00870
      Location:56250
      P53; P53 DNA-binding domain
      pfam07710
      Location:280319
      P53_tetramer; P53 tetramerisation motif
    15. NM_001276761.3NP_001263690.1  cellular tumor antigen p53 isoform g

      See identical proteins and their annotated locations for NP_001263690.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (g, also known as delta40p53alpha or deltaNp53) results from translation initiation at the downstream start codon. It has a shorter N-terminus, compared to isoform a. Variants 1, 2, and 8 encode isoform g.
      Source sequence(s)
      AB082923, AK223026, DA453049, X02469
      Consensus CDS
      CCDS73969.1
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      H2EHT1, Q53GA5
      Related
      ENSP00000482537.1, ENST00000619485.4
      Conserved Domains (2) summary
      pfam00870
      Location:56250
      P53; P53 DNA-binding domain
      pfam07710
      Location:280319
      P53_tetramer; P53 tetramerisation motif

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      7668402..7687550 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center