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HNRNPDL heterogeneous nuclear ribonucleoprotein D like [ Homo sapiens (human) ]

Gene ID: 9987, updated on 12-Aug-2018

Summary

Official Symbol
HNRNPDLprovided by HGNC
Official Full Name
heterogeneous nuclear ribonucleoprotein D likeprovided by HGNC
Primary source
HGNC:HGNC:5037
See related
Ensembl:ENSG00000152795 MIM:607137; Vega:OTTHUMG00000130299
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HNRNP; JKTBP; HNRPDL; JKTBP2; LGMD1G; laAUF1
Summary
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two RRM domains that bind to RNAs. Three alternatively spliced transcript variants have been described for this gene. One of the variants is probably not translated because the transcript is a candidate for nonsense-mediated mRNA decay. The protein isoforms encoded by this gene are similar to its family member HNRPD. [provided by RefSeq, May 2011]
Expression
Ubiquitous expression in ovary (RPKM 71.3), endometrium (RPKM 57.4) and 25 other tissues See more
Orthologs

Genomic context

See HNRNPDL in Genome Data Viewer
Location:
4q21.22
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (82422564..82430225, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (83343717..83351378, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928963 Neighboring gene immunoglobulin (CD79A) binding protein 1 pseudogene 4 Neighboring gene enolase-phosphatase 1 Neighboring gene syncytin-1-like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of heterogeneous nuclear ribonucleoprotein D-like (HNRPDL) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, heterogeneous nuclear ribonucleoprotein D-like (HNRPDL), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with HNRPDL is increased by RRE PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
poly(G) binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sequence-specific double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
interleukin-12-mediated signaling pathway TAS
Traceable Author Statement
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
heterogeneous nuclear ribonucleoprotein D-like
Names
A+U-rich element RNA binding factor
AU-rich element RNA-binding factor
JKT41-binding protein
hnRNP D-like
hnRNP DL
protein laAUF1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029681.1 RefSeqGene

    Range
    5001..12662
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001207000.1NP_001193929.1  heterogeneous nuclear ribonucleoprotein D-like isoform b

    See identical proteins and their annotated locations for NP_001193929.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 3. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AB017019, AB066484, AC124016, BC071944, CK300994
    Consensus CDS
    CCDS75153.1
    UniProtKB/Swiss-Prot
    O14979
    UniProtKB/TrEMBL
    A0A087WUK2
    Related
    ENSP00000478723.1, ENST00000614627.4
    Conserved Domains (2) summary
    cd12585
    Location:234308
    RRM2_hnRPDL; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein D-like (hnRNP DL) and similar proteins
    cd12758
    Location:149224
    RRM1_hnRPDL; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein D-like (hnRNP D-like or hnRNP DL) and similar proteins
  2. NM_031372.3NP_112740.1  heterogeneous nuclear ribonucleoprotein D-like isoform a

    See identical proteins and their annotated locations for NP_112740.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the longer isoform (a).
    Source sequence(s)
    AB017019, AC124016, BC071944, CK300994
    Consensus CDS
    CCDS3593.1
    UniProtKB/Swiss-Prot
    O14979
    UniProtKB/TrEMBL
    A0A024RDF6
    Related
    ENSP00000483254.1, ENST00000621267.4
    Conserved Domains (2) summary
    cd12585
    Location:234308
    RRM2_hnRPDL; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein D-like (hnRNP DL) and similar proteins
    cd12758
    Location:149224
    RRM1_hnRPDL; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein D-like (hnRNP D-like or hnRNP DL) and similar proteins

RNA

  1. NR_003249.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. However, this transcript is a candidate for nonsense-mediated mRNA decay (NMD), and so it is thought to be a noncoding transcript.
    Source sequence(s)
    AB017019, AC124016, CK300994

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    82422564..82430225 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_005463.2: Suppressed sequence

    Description
    NM_005463.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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