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CLEC2B C-type lectin domain family 2 member B [ Homo sapiens (human) ]

Gene ID: 9976, updated on 1-Aug-2020

Summary

Official Symbol
CLEC2Bprovided by HGNC
Official Full Name
C-type lectin domain family 2 member Bprovided by HGNC
Primary source
HGNC:HGNC:2053
See related
Ensembl:ENSG00000110852 MIM:603242
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AICL; IFNRG1; CLECSF2; HP10085
Summary
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell activation antigen. An alternative splice variant has been described but its full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
Expression
Broad expression in skin (RPKM 19.0), bone marrow (RPKM 18.7) and 22 other tissues See more
Orthologs

Genomic context

See CLEC2B in Genome Data Viewer
Location:
12p13.31
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (9852369..9869859, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (10004968..10022458, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr12.528 Neighboring gene killer cell lectin like receptor F1 Neighboring gene GCNA pseudogene 1 Neighboring gene C-type lectin domain family 2 member A Neighboring gene killer cell lectin like receptor F2 Neighboring gene long intergenic non-protein coding RNA 2470

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of immune response TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
C-type lectin domain family 2 member B
Names
C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 2 (activation-induced)
C-type lectin superfamily member 2
IFN-alpha-2b-inducing-related protein 1
IFN-alpha2b-inducing related protein 1
activation-induced C-type lectin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005127.2NP_005118.2  C-type lectin domain family 2 member B

    See identical proteins and their annotated locations for NP_005118.2

    Status: REVIEWED

    Source sequence(s)
    AC007068, AC091814, AK313916, BG779377, BM973072
    Consensus CDS
    CCDS8605.1
    UniProtKB/Swiss-Prot
    Q92478
    Related
    ENSP00000228438.2, ENST00000228438.2
    Conserved Domains (2) summary
    cd03593
    Location:35146
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    pfam05473
    Location:847
    UL45; UL45 protein, carbohydrate-binding C-type lectin-like

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    9852369..9869859 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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