Format

Send to:

Choose Destination

NR1I3 nuclear receptor subfamily 1 group I member 3 [ Homo sapiens (human) ]

Gene ID: 9970, updated on 3-Jan-2019

Summary

Official Symbol
NR1I3provided by HGNC
Official Full Name
nuclear receptor subfamily 1 group I member 3provided by HGNC
Primary source
HGNC:HGNC:7969
See related
Ensembl:ENSG00000143257 MIM:603881
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAR; CAR1; MB67
Summary
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in liver (RPKM 24.0), kidney (RPKM 3.5) and 6 other tissues See more
Orthologs

Genomic context

See NR1I3 in Genome Data Viewer
Location:
1q23.3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (161229666..161238623, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161199456..161208432, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene apolipoprotein A2 Neighboring gene translocase of outer mitochondrial membrane 40 like Neighboring gene microRNA 5187 Neighboring gene Purkinje cell protein 4 like 1 Neighboring gene uncharacterized LOC105371472 Neighboring gene uncharacterized LOC107985221

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC97144, MGC97209, MGC150433

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific NAS
Non-traceable Author Statement
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 
nuclear receptor transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
steroid hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 
transcription coactivator activity TAS
Traceable Author Statement
more info
PubMed 
transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
steroid hormone mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
RNA polymerase II transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
nuclear receptor subfamily 1 group I member 3
Names
constitutive activator of retinoid response
constitutive active receptor
constitutive active response
constitutive androstane nuclear receptor variant 2
constitutive androstane nuclear receptor variant 3
constitutive androstane nuclear receptor variant 4
constitutive androstane nuclear receptor variant 5
constitutive androstane receptor
orphan nuclear hormone receptor
orphan nuclear receptor MB67

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029113.1 RefSeqGene

    Range
    5001..13545
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001077469.2NP_001070937.1  nuclear receptor subfamily 1 group I member 3 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), also known as SV-1, uses two alternate splice sites in the 3' coding region, compared to variant 1. The resulting protein (isoform 6) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA918394, AY572806, CB124867
    Consensus CDS
    CCDS44261.1
    UniProtKB/Swiss-Prot
    Q14994
    Related
    ENSP00000412672.2, ENST00000428574.6
    Conserved Domains (2) summary
    cd07156
    Location:1182
    NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers
    cl11397
    Location:106311
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  2. NM_001077470.2NP_001070938.1  nuclear receptor subfamily 1 group I member 3 isoform 11

    See identical proteins and their annotated locations for NP_001070938.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), also known as SV-3, lacks two alternate in-frame exons and uses an alternate splice site, compared to variant 1. The resulting protein (isoform 11) is shorter, uses an upstream start codon, and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AA918394, AY572808, CB124867
    Consensus CDS
    CCDS53407.1
    UniProtKB/Swiss-Prot
    Q14994
    Related
    ENSP00000424345.1, ENST00000504010.5
    Conserved Domains (2) summary
    cl02596
    Location:753
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    cl11397
    Location:77278
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  3. NM_001077471.2NP_001070939.1  nuclear receptor subfamily 1 group I member 3 isoform 5

    See identical proteins and their annotated locations for NP_001070939.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), also known as SV-5 or CAR3, lacks an alternate in-frame exon and uses an alternate splice site, compared to variant 1. The resulting protein (isoform 5) is shorter than isoform 1.
    Source sequence(s)
    AA918394, AY572810, CB124867
    Consensus CDS
    CCDS44262.1
    UniProtKB/Swiss-Prot
    Q14994
    Related
    ENSP00000356963.4, ENST00000367984.8
    Conserved Domains (2) summary
    cd07156
    Location:1182
    NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers
    cl11397
    Location:106307
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  4. NM_001077472.2NP_001070940.1  nuclear receptor subfamily 1 group I member 3 isoform 9

    See identical proteins and their annotated locations for NP_001070940.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), also known as SV-6, lacks an alternate in-frame exon in the 5' coding region and uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting protein (isoform 9) is shorter, uses an upstream start codon, and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AA918394, AY572811, CB124867
    Consensus CDS
    CCDS41427.1
    UniProtKB/Swiss-Prot
    Q14994
    Related
    ENSP00000356960.3, ENST00000367981.7
    Conserved Domains (2) summary
    cd06934
    Location:77322
    NR_LBD_PXR_like; The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor
    cl02596
    Location:753
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
  5. NM_001077473.2NP_001070941.1  nuclear receptor subfamily 1 group I member 3 isoform 12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), also known as SV-7, lacks an alternate in-frame exon in the 5' coding region and uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting protein (isoform 12) is shorter, uses an upstream start codon, and has distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AA918394, AY572812, CB124867
    Consensus CDS
    CCDS53411.1
    UniProtKB/Swiss-Prot
    Q14994
    Related
    ENSP00000399361.2, ENST00000412844.6
    Conserved Domains (2) summary
    cl02596
    Location:753
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    cl11397
    Location:77286
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  6. NM_001077474.2NP_001070942.1  nuclear receptor subfamily 1 group I member 3 isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), also known as SV-8, lacks an alternate in-frame exon and uses two alternate splice sites in the 3' coding region, compared to variant 1. The resulting protein (isoform 8) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA918394, AY572813, CB124867
    Consensus CDS
    CCDS53405.1
    UniProtKB/Swiss-Prot
    Q14994
    Related
    ENSP00000424934.1, ENST00000505005.5
    Conserved Domains (2) summary
    cd07156
    Location:1182
    NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers
    cl11397
    Location:106267
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  7. NM_001077475.2NP_001070943.1  nuclear receptor subfamily 1 group I member 3 isoform 15

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), also known as SV-11, lacks two alternate in-frame exons and uses two alternate splice sites, compared to variant 1. The resulting protein (isoform 15) is shorter, uses an upstream start codon, and has distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AA918394, AY572816, CB124867
    Consensus CDS
    CCDS53406.1
    UniProtKB/Swiss-Prot
    Q14994
    Related
    ENSP00000425417.1, ENST00000512372.5
    Conserved Domains (2) summary
    cl02596
    Location:753
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    cl11397
    Location:77238
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  8. NM_001077476.2NP_001070944.1  nuclear receptor subfamily 1 group I member 3 isoform 13

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), also known as SV-12, lacks an alternate in-frame exon in the 5' coding region and uses two alternate splice sites in the 3' coding region, compared to variant 1. The resulting protein (isoform 13) is shorter, uses an upstream start codon, and has distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AA918394, AY572817, CB124867
    Consensus CDS
    CCDS53410.1
    UniProtKB/Swiss-Prot
    Q14994
    Related
    ENSP00000423666.1, ENST00000508740.5
    Conserved Domains (2) summary
    cl02596
    Location:753
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    cl11397
    Location:77282
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  9. NM_001077477.2NP_001070945.1  nuclear receptor subfamily 1 group I member 3 isoform 14

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), also known as SV-13, lacks an alternate in-frame exon in the 5' coding region and uses three alternate splice sites in the 3' coding region, compared to variant 1. The resulting protein (isoform 14) is shorter, uses an upstream start codon, and has distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AA918394, AY572818, CB124867
    Consensus CDS
    CCDS53408.1
    UniProtKB/Swiss-Prot
    Q14994
    Related
    ENSP00000407446.2, ENST00000437437.6
    Conserved Domains (2) summary
    cl02596
    Location:753
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    cl11397
    Location:77277
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  10. NM_001077478.2NP_001070946.1  nuclear receptor subfamily 1 group I member 3 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), also known as SV-14, uses two alternate splice sites in the 3' coding region, compared to variant 1. The resulting protein (isoform 7) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA918394, AY572819, CB124867
    Consensus CDS
    CCDS44260.1
    UniProtKB/Swiss-Prot
    Q14994
    Related
    ENSP00000406493.2, ENST00000442691.6
    Conserved Domains (2) summary
    cd07156
    Location:1182
    NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers
    cl11397
    Location:106310
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  11. NM_001077479.2NP_001070947.1  nuclear receptor subfamily 1 group I member 3 isoform 10

    See identical proteins and their annotated locations for NP_001070947.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), also known as SV-22, lacks an alternate in-frame exon in the 5' coding region and uses two alternate splice sites in the 3' coding region, compared to variant 1. The resulting protein (isoform 10) is shorter, uses an upstream start codon, and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AA918394, AY572827, CB124867
    Consensus CDS
    CCDS53409.1
    UniProtKB/Swiss-Prot
    Q14994
    Related
    ENSP00000427175.1, ENST00000511676.5
    Conserved Domains (2) summary
    cd06934
    Location:77317
    NR_LBD_PXR_like; The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor
    cl02596
    Location:753
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
  12. NM_001077480.2NP_001070948.1  nuclear receptor subfamily 1 group I member 3 isoform 2

    See identical proteins and their annotated locations for NP_001070948.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AA918394, AL590714, BC069626, CB124867
    Consensus CDS
    CCDS41430.1
    UniProtKB/Swiss-Prot
    Q14994
    Related
    ENSP00000356961.4, ENST00000367982.8
    Conserved Domains (2) summary
    cd06934
    Location:106350
    NR_LBD_PXR_like; The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor
    cd07156
    Location:1182
    NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers
  13. NM_001077481.2NP_001070949.1  nuclear receptor subfamily 1 group I member 3 isoform 4

    See identical proteins and their annotated locations for NP_001070949.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 4) is shorter than isoform 1.
    Source sequence(s)
    AA918394, AL590714, BC121120, CB124867
    Consensus CDS
    CCDS41428.1
    UniProtKB/Swiss-Prot
    Q14994
    Related
    ENSP00000356965.3, ENST00000367985.7
    Conserved Domains (2) summary
    cd07156
    Location:1182
    NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers
    cl11397
    Location:106312
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  14. NM_001077482.2NP_001070950.1  nuclear receptor subfamily 1 group I member 3 isoform 1

    See identical proteins and their annotated locations for NP_001070950.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as SV-25 or CAR2, represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA918394, BC121120, CB124867, DQ022681
    Consensus CDS
    CCDS41429.1
    UniProtKB/Swiss-Prot
    Q14994
    Related
    ENSP00000356959.2, ENST00000367980.6
    Conserved Domains (2) summary
    cd06934
    Location:106355
    NR_LBD_PXR_like; The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor
    cd07156
    Location:1182
    NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers
  15. NM_005122.4NP_005113.1  nuclear receptor subfamily 1 group I member 3 isoform 3

    See identical proteins and their annotated locations for NP_005113.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as WT or REF, uses two alternate splice sites in the 3' coding region, compared to variant 1. The resulting protein (isoform 3) is shorter than isoform 1.
    Source sequence(s)
    AA918394, CB124867, Z30425
    Consensus CDS
    CCDS1228.1
    UniProtKB/Swiss-Prot
    Q14994
    Related
    ENSP00000356962.4, ENST00000367983.8
    Conserved Domains (2) summary
    cd06934
    Location:106346
    NR_LBD_PXR_like; The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor
    cd07156
    Location:1182
    NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    161229666..161238623 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245694.5XP_005245751.1  nuclear receptor subfamily 1 group I member 3 isoform X2

    Conserved Domains (2) summary
    cd06934
    Location:178422
    NR_LBD_PXR_like; The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor
    cl02596
    Location:108154
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
  2. XM_005245693.4XP_005245750.1  nuclear receptor subfamily 1 group I member 3 isoform X1

    Conserved Domains (2) summary
    cd06934
    Location:178427
    NR_LBD_PXR_like; The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor
    cl02596
    Location:108154
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
  3. XM_011510237.3XP_011508539.1  nuclear receptor subfamily 1 group I member 3 isoform X3

    Conserved Domains (2) summary
    cl02596
    Location:108154
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    cl11397
    Location:178384
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  4. XM_005245697.4XP_005245754.1  nuclear receptor subfamily 1 group I member 3 isoform X4

    See identical proteins and their annotated locations for XP_005245754.1

    UniProtKB/TrEMBL
    F1DAL4
    Conserved Domains (2) summary
    cd06934
    Location:106351
    NR_LBD_PXR_like; The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor
    cd07156
    Location:1182
    NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers
Support Center