U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

NR1I3 nuclear receptor subfamily 1 group I member 3 [ Homo sapiens (human) ]

Gene ID: 9970, updated on 27-Nov-2024

Summary

Official Symbol
NR1I3provided by HGNC
Official Full Name
nuclear receptor subfamily 1 group I member 3provided by HGNC
Primary source
HGNC:HGNC:7969
See related
Ensembl:ENSG00000143257 MIM:603881; AllianceGenome:HGNC:7969
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAR; CAR1; MB67
Summary
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. In addition to drug metabolism, the CAR protein is also reported to regulate genes involved in glucose metabolism, lipid metabolism, cell proliferation, and circadian clock regulation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2020]
Expression
Biased expression in liver (RPKM 24.0), kidney (RPKM 3.5) and 6 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See NR1I3 in Genome Data Viewer
Location:
1q23.3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (161229669..161238203, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (160367115..160375669, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161199459..161207993, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1987 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1988 Neighboring gene apolipoprotein A2 Neighboring gene translocase of outer mitochondrial membrane 40 like Neighboring gene microRNA 5187 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:161228903-161229403 Neighboring gene Purkinje cell protein 4 like 1 Neighboring gene uncharacterized LOC105371472 Neighboring gene uncharacterized LOC107985221

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC97144, MGC97209, MGC150433

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
nuclear receptor subfamily 1 group I member 3
Names
constitutive activator of retinoid response
constitutive active receptor
constitutive active response
constitutive androstane receptor
orphan nuclear hormone receptor
orphan nuclear receptor MB67

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029113.1 RefSeqGene

    Range
    5008..13542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001077469.3NP_001070937.1  nuclear receptor subfamily 1 group I member 3 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), also known as SV-1, uses two alternate splice sites in the 3' coding region, compared to variant 1. The resulting protein (isoform 6) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA918394, AY572806, CB124867
    Consensus CDS
    CCDS44261.1
    UniProtKB/TrEMBL
    E9PCF2
    Related
    ENSP00000412672.2, ENST00000428574.6
    Conserved Domains (2) summary
    cd07156
    Location:1182
    NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers
    cl11397
    Location:106311
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  2. NM_001077470.3NP_001070938.1  nuclear receptor subfamily 1 group I member 3 isoform 11

    See identical proteins and their annotated locations for NP_001070938.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), also known as SV-3, lacks two alternate in-frame exons and uses an alternate splice site, compared to variant 1. The resulting protein (isoform 11) is shorter, uses an upstream start codon, and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AA918394, AY572808, CB124867
    Consensus CDS
    CCDS53407.1
    UniProtKB/TrEMBL
    B6ZGT2
    Related
    ENSP00000424345.1, ENST00000504010.5
    Conserved Domains (2) summary
    cl02596
    Location:753
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    cl11397
    Location:77278
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  3. NM_001077471.3NP_001070939.1  nuclear receptor subfamily 1 group I member 3 isoform 5

    See identical proteins and their annotated locations for NP_001070939.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), also known as SV-5 or CAR3, lacks an alternate in-frame exon and uses an alternate splice site, compared to variant 1. The resulting protein (isoform 5) is shorter than isoform 1.
    Source sequence(s)
    AA918394, AY572810, CB124867
    Consensus CDS
    CCDS44262.1
    UniProtKB/TrEMBL
    B6ZGT2
    Related
    ENSP00000356963.4, ENST00000367984.8
    Conserved Domains (2) summary
    cd07156
    Location:1182
    NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers
    cl11397
    Location:106307
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  4. NM_001077472.3NP_001070940.1  nuclear receptor subfamily 1 group I member 3 isoform 9

    See identical proteins and their annotated locations for NP_001070940.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), also known as SV-6, lacks an alternate in-frame exon in the 5' coding region and uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting protein (isoform 9) is shorter, uses an upstream start codon, and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AA918394, AY572811, CB124867
    Consensus CDS
    CCDS41427.1
    UniProtKB/TrEMBL
    D6REZ7
    Related
    ENSP00000356960.3, ENST00000367981.7
    Conserved Domains (2) summary
    cd06934
    Location:77322
    NR_LBD_PXR_like; The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor
    cl02596
    Location:753
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
  5. NM_001077473.3NP_001070941.1  nuclear receptor subfamily 1 group I member 3 isoform 12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), also known as SV-7, lacks an alternate in-frame exon in the 5' coding region and uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting protein (isoform 12) is shorter, uses an upstream start codon, and has distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AA918394, AY572812, CB124867
    Consensus CDS
    CCDS53411.1
    UniProtKB/TrEMBL
    E9PCF2
    Related
    ENSP00000399361.2, ENST00000412844.6
    Conserved Domains (2) summary
    cl02596
    Location:753
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    cl11397
    Location:77286
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  6. NM_001077474.3NP_001070942.1  nuclear receptor subfamily 1 group I member 3 isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), also known as SV-8, lacks an alternate in-frame exon and uses two alternate splice sites in the 3' coding region, compared to variant 1. The resulting protein (isoform 8) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA918394, AY572813, CB124867
    Consensus CDS
    CCDS53405.1
    UniProtKB/TrEMBL
    B6ZGT2
    Related
    ENSP00000424934.1, ENST00000505005.5
    Conserved Domains (2) summary
    cd07156
    Location:1182
    NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers
    cl11397
    Location:106267
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  7. NM_001077475.3NP_001070943.1  nuclear receptor subfamily 1 group I member 3 isoform 15

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), also known as SV-11, lacks two alternate in-frame exons and uses two alternate splice sites, compared to variant 1. The resulting protein (isoform 15) is shorter, uses an upstream start codon, and has distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AA918394, AY572816, CB124867
    Consensus CDS
    CCDS53406.1
    UniProtKB/TrEMBL
    E9PCF2
    Related
    ENSP00000425417.1, ENST00000512372.5
    Conserved Domains (2) summary
    cl02596
    Location:753
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    cl11397
    Location:77238
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  8. NM_001077476.3NP_001070944.1  nuclear receptor subfamily 1 group I member 3 isoform 13

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), also known as SV-12, lacks an alternate in-frame exon in the 5' coding region and uses two alternate splice sites in the 3' coding region, compared to variant 1. The resulting protein (isoform 13) is shorter, uses an upstream start codon, and has distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AA918394, AY572817, CB124867
    Consensus CDS
    CCDS53410.1
    UniProtKB/TrEMBL
    E9PCF2
    Related
    ENSP00000423666.1, ENST00000508740.5
    Conserved Domains (2) summary
    cl02596
    Location:753
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    cl11397
    Location:77282
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  9. NM_001077477.3NP_001070945.1  nuclear receptor subfamily 1 group I member 3 isoform 14

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), also known as SV-13, lacks an alternate in-frame exon in the 5' coding region and uses three alternate splice sites in the 3' coding region, compared to variant 1. The resulting protein (isoform 14) is shorter, uses an upstream start codon, and has distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AA918394, AY572818, CB124867
    Consensus CDS
    CCDS53408.1
    UniProtKB/TrEMBL
    E9PCF2
    Related
    ENSP00000407446.2, ENST00000437437.6
    Conserved Domains (2) summary
    cl02596
    Location:753
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    cl11397
    Location:77277
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  10. NM_001077478.3NP_001070946.1  nuclear receptor subfamily 1 group I member 3 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), also known as SV-14, uses two alternate splice sites in the 3' coding region, compared to variant 1. The resulting protein (isoform 7) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA918394, AY572819, CB124867
    Consensus CDS
    CCDS44260.1
    UniProtKB/TrEMBL
    E9PCF2
    Related
    ENSP00000406493.2, ENST00000442691.6
    Conserved Domains (2) summary
    cd07156
    Location:1182
    NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers
    cl11397
    Location:106310
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  11. NM_001077479.3NP_001070947.1  nuclear receptor subfamily 1 group I member 3 isoform 10

    See identical proteins and their annotated locations for NP_001070947.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), also known as SV-22, lacks an alternate in-frame exon in the 5' coding region and uses two alternate splice sites in the 3' coding region, compared to variant 1. The resulting protein (isoform 10) is shorter, uses an upstream start codon, and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AA918394, AY572827, CB124867
    Consensus CDS
    CCDS53409.1
    UniProtKB/TrEMBL
    D6REZ7
    Related
    ENSP00000427175.1, ENST00000511676.5
    Conserved Domains (2) summary
    cd06934
    Location:77317
    NR_LBD_PXR_like; The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor
    cl02596
    Location:753
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
  12. NM_001077480.3NP_001070948.1  nuclear receptor subfamily 1 group I member 3 isoform 2

    See identical proteins and their annotated locations for NP_001070948.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AA918394, AL590714, BC069626, CB124867
    Consensus CDS
    CCDS41430.1
    UniProtKB/Swiss-Prot
    E9PB75, E9PC13, E9PDU3, E9PGH6, E9PH10, E9PHC8, E9PHN4, F1D8Q0, F1D8Q1, Q0VAC9, Q14994, Q4U0F0, Q5VTW5, Q5VTW6, Q6GZ68, Q6GZ76, Q6GZ77, Q6GZ78, Q6GZ79, Q6GZ82, Q6GZ83, Q6GZ84, Q6GZ85, Q6GZ87, Q6GZ89
    UniProtKB/TrEMBL
    B6ZGT2
    Related
    ENSP00000356961.4, ENST00000367982.8
    Conserved Domains (2) summary
    cd06934
    Location:106350
    NR_LBD_PXR_like; The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor
    cd07156
    Location:1182
    NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers
  13. NM_001077481.3NP_001070949.1  nuclear receptor subfamily 1 group I member 3 isoform 4

    See identical proteins and their annotated locations for NP_001070949.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 4) is shorter than isoform 1.
    Source sequence(s)
    AA918394, AL590714, BC121120, CB124867
    Consensus CDS
    CCDS41428.1
    UniProtKB/TrEMBL
    B6ZGT2
    Related
    ENSP00000356965.3, ENST00000367985.7
    Conserved Domains (2) summary
    cd07156
    Location:1182
    NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers
    cl11397
    Location:106312
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  14. NM_001077482.3NP_001070950.1  nuclear receptor subfamily 1 group I member 3 isoform 1

    See identical proteins and their annotated locations for NP_001070950.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as SV-25 or CAR2, represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA918394, BC121120, CB124867, DQ022681
    Consensus CDS
    CCDS41429.1
    UniProtKB/TrEMBL
    B6ZGT2
    Related
    ENSP00000356959.2, ENST00000367980.6
    Conserved Domains (2) summary
    cd06934
    Location:106355
    NR_LBD_PXR_like; The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor
    cd07156
    Location:1182
    NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers
  15. NM_005122.5NP_005113.1  nuclear receptor subfamily 1 group I member 3 isoform 3

    See identical proteins and their annotated locations for NP_005113.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as WT or REF, uses two alternate splice sites in the 3' coding region, compared to variant 1. The resulting protein (isoform 3) is shorter than isoform 1.
    Source sequence(s)
    CB124867, Z30425
    Consensus CDS
    CCDS1228.1
    UniProtKB/TrEMBL
    B6ZGT2
    Related
    ENSP00000356962.5, ENST00000367983.9
    Conserved Domains (2) summary
    cd06934
    Location:106346
    NR_LBD_PXR_like; The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor
    cd07156
    Location:1182
    NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    161229669..161238203 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245693.5XP_005245750.2  nuclear receptor subfamily 1 group I member 3 isoform X2

  2. XM_005245697.5XP_005245754.1  nuclear receptor subfamily 1 group I member 3 isoform X1

    See identical proteins and their annotated locations for XP_005245754.1

    UniProtKB/TrEMBL
    B6ZGT2, F1DAL4
    Conserved Domains (2) summary
    cd06934
    Location:106351
    NR_LBD_PXR_like; The ligand binding domain of xenobiotic receptors:pregnane X receptor and constitutive androstane receptor
    cd07156
    Location:1182
    NR_DBD_VDR_like; The DNA-binding domain of vitamin D receptors (VDR) like nuclear receptor family is composed of two C4-type zinc fingers

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    160367115..160375669 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339984.1XP_054195959.1  nuclear receptor subfamily 1 group I member 3 isoform X2

  2. XM_054339983.1XP_054195958.1  nuclear receptor subfamily 1 group I member 3 isoform X1

    UniProtKB/TrEMBL
    F1DAL4