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Sec24b Sec24 related gene family, member B (S. cerevisiae) [ Mus musculus (house mouse) ]

Gene ID: 99683, updated on 26-Sep-2022

Summary

Official Symbol
Sec24bprovided by MGI
Official Full Name
Sec24 related gene family, member B (S. cerevisiae)provided by MGI
Primary source
MGI:MGI:2139764
See related
Ensembl:ENSMUSG00000001052 AllianceGenome:MGI:2139764
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SEC24
Summary
Predicted to enable SNARE binding activity and zinc ion binding activity. Acts upstream of or within several processes, including animal organ development; artery morphogenesis; and regulation of cargo loading into COPII-coated vesicle. Part of COPII vesicle coat. Is expressed in cochlear duct and embryo. Orthologous to human SEC24B (SEC24 homolog B, COPII coat complex component). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 37.4), thymus adult (RPKM 21.6) and 28 other tissues See more
Orthologs
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Genomic context

See Sec24b in Genome Data Viewer
Location:
3; 3 G3
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (129776408..129855248, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (129982759..130061599, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40150 Neighboring gene caspase 6 Neighboring gene mitochondrial calcium uniporter dominant negative beta subunit Neighboring gene predicted gene, 40151 Neighboring gene predicted gene 9396 Neighboring gene makorin, ring finger protein, 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (3)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in COPII-coated vesicle cargo loading IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in COPII-coated vesicle cargo loading ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within aorta morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within auditory receptor cell morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within auditory receptor cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within auditory receptor cell stereocilium organization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within auditory receptor cell stereocilium organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within circulatory system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cochlear nucleus development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cochlear nucleus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within coronary artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lung lobe morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neural tube closure IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within pulmonary artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cargo loading into COPII-coated vesicle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of establishment of planar polarity involved in neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of COPII vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of COPII vesicle coat IDA
Inferred from Direct Assay
more info
PubMed 
part_of COPII vesicle coat ISO
Inferred from Sequence Orthology
more info
 
located_in COPII-coated ER to Golgi transport vesicle ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein transport protein Sec24B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411432.1NP_001398361.1  protein transport protein Sec24B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC118620
  2. NM_001411433.1NP_001398362.1  protein transport protein Sec24B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC118620
  3. NM_207209.4NP_997092.1  protein transport protein Sec24B isoform 1

    See identical proteins and their annotated locations for NP_997092.1

    Status: VALIDATED

    Source sequence(s)
    AC118620
    Consensus CDS
    CCDS17840.1
    UniProtKB/TrEMBL
    Q80ZX0
    Related
    ENSMUSP00000001079.9, ENSMUST00000001079.15
    Conserved Domains (6) summary
    cd01479
    Location:658901
    Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
    pfam00626
    Location:11221197
    Gelsolin; Gelsolin repeat
    pfam04810
    Location:585621
    zf-Sec23_Sec24; Sec23/Sec24 zinc finger
    pfam04815
    Location:10011096
    Sec23_helical; Sec23/Sec24 helical domain
    pfam07223
    Location:27226
    DUF1421; Protein of unknown function (DUF1421)
    pfam08033
    Location:902986
    Sec23_BS; Sec23/Sec24 beta-sandwich domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    129776408..129855248 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163481.1XP_036019374.1  protein transport protein Sec24B isoform X2

    Conserved Domains (1) summary
    COG5028
    Location:4781210
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
  2. XM_006502469.5XP_006502532.1  protein transport protein Sec24B isoform X1

    Conserved Domains (1) summary
    COG5028
    Location:4821214
    COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]