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THRAP3 thyroid hormone receptor associated protein 3 [ Homo sapiens (human) ]

Gene ID: 9967, updated on 4-Nov-2018

Summary

Official Symbol
THRAP3provided by HGNC
Official Full Name
thyroid hormone receptor associated protein 3provided by HGNC
Primary source
HGNC:HGNC:22964
See related
Ensembl:ENSG00000054118 MIM:603809; Vega:OTTHUMG00000007866
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BCLAF2; TRAP150
Expression
Ubiquitous expression in lymph node (RPKM 27.3), thyroid (RPKM 26.7) and 25 other tissues See more
Orthologs

Genomic context

See THRAP3 in Genome Data Viewer
Location:
1p34.3
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (36224412..36305357)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (36690017..36770958)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex 3 Neighboring gene MAP7 domain containing 1 Neighboring gene RNA, 7SL, cytoplasmic 131, pseudogene Neighboring gene Sharpr-MPRA regulatory regions 10257 and 14041 Neighboring gene ubiquitin conjugating enzyme E2 V2 pseudogene 4 Neighboring gene SH3 domain containing 21 Neighboring gene eva-1 homolog B Neighboring gene serine/threonine kinase 40

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag is identified to have a physical interaction with thyroid hormone receptor associated protein 3 (THRAP3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
integrase gag-pol Using acetylated HIV-1 IN as bait in yeast two-hybrid screening identifies transcription regulatory and chromatin remodeling factors LEDGF/p75, KAP1, BTF3b, THRAP3, and HMGN2 as IN-binding partners PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human thyroid hormone receptor associated protein 3 (THRAP3) at amino acid residues 473-474 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22082, MGC133082, MGC133083

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
RNA polymerase II distal enhancer sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear receptor transcription coactivator activity NAS
Non-traceable Author Statement
more info
PubMed 
phosphoprotein binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
thyroid hormone receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription coregulator activity IDA
Inferred from Direct Assay
more info
PubMed 
vitamin D receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with exon-exon junction complex IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
mediator complex IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
thyroid hormone receptor-associated protein 3
Names
BCLAF1 and THRAP3 family member 2
TR-associated protein, 150-kDa
thyroid hormone receptor-associated protein complex 150 kDa component
thyroid hormone receptor-associated protein, 150 kDa subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321471.1NP_001308400.1  thyroid hormone receptor-associated protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC114484, AI754117, AK025735, BC112350, HY001123
    Consensus CDS
    CCDS405.1
    UniProtKB/Swiss-Prot
    Q9Y2W1
    Related
    ENSP00000433825.1, OTTHUMP00000230679, ENST00000469141.6, OTTHUMT00000023220
    Conserved Domains (1) summary
    pfam15440
    Location:191769
    THRAP3_BCLAF1; THRAP3/BCLAF1 family
  2. NM_001321473.1NP_001308402.1  thyroid hormone receptor-associated protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AI754117, AK025735, BC112330, HY001123
    UniProtKB/Swiss-Prot
    Q9Y2W1
    Conserved Domains (1) summary
    pfam15440
    Location:191769
    THRAP3_BCLAF1; THRAP3/BCLAF1 family
  3. NM_005119.3NP_005110.2  thyroid hormone receptor-associated protein 3 isoform 1

    See identical proteins and their annotated locations for NP_005110.2

    Status: VALIDATED

    Source sequence(s)
    AI754117, AK025735, BC112350, BG572651
    Consensus CDS
    CCDS405.1
    UniProtKB/Swiss-Prot
    Q9Y2W1
    Related
    ENSP00000346634.5, OTTHUMP00000009597, ENST00000354618.9, OTTHUMT00000021688
    Conserved Domains (1) summary
    pfam15440
    Location:191769
    THRAP3_BCLAF1; THRAP3/BCLAF1 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    36224412..36305357
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451302.1XP_024307070.1  thyroid hormone receptor-associated protein 3 isoform X1

    Conserved Domains (1) summary
    pfam15440
    Location:1382
    THRAP3_BCLAF1; THRAP3/BCLAF1 family
  2. XM_024451301.1XP_024307069.1  thyroid hormone receptor-associated protein 3 isoform X1

    Conserved Domains (1) summary
    pfam15440
    Location:1382
    THRAP3_BCLAF1; THRAP3/BCLAF1 family

RNA

  1. XR_002958230.1 RNA Sequence

  2. XR_002958231.1 RNA Sequence

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