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FGF19 fibroblast growth factor 19 [ Homo sapiens (human) ]

Gene ID: 9965, updated on 28-Jun-2020

Summary

Official Symbol
FGF19provided by HGNC
Official Full Name
fibroblast growth factor 19provided by HGNC
Primary source
HGNC:HGNC:3675
See related
Ensembl:ENSG00000162344 MIM:603891
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward gall bladder (RPKM 132.5) See more
Orthologs

Genomic context

See FGF19 in Genome Data Viewer
Location:
11q13.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (69698238..69704022, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (69513006..69519106, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene cyclin D1 Neighboring gene LTO1 maturation factor of ABCE1 Neighboring gene FGF19 5' regulatory region Neighboring gene FGF19 upstream enhancer

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
fibroblast growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
fibroblast growth factor 19
Names
FGF-19

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005117.3NP_005108.1  fibroblast growth factor 19 precursor

    See identical proteins and their annotated locations for NP_005108.1

    Status: REVIEWED

    Source sequence(s)
    AF110400
    Consensus CDS
    CCDS8193.1
    UniProtKB/Swiss-Prot
    O95750
    Related
    ENSP00000294312.3, ENST00000294312.4
    Conserved Domains (1) summary
    smart00442
    Location:41168
    FGF; Acidic and basic fibroblast growth factor family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    69698238..69704022 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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