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USP15 ubiquitin specific peptidase 15 [ Homo sapiens (human) ]

Gene ID: 9958, updated on 10-Oct-2020

Summary

Official Symbol
USP15provided by HGNC
Official Full Name
ubiquitin specific peptidase 15provided by HGNC
Primary source
HGNC:HGNC:12613
See related
Ensembl:ENSG00000135655 MIM:604731
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UNPH4; UNPH-2
Summary
This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2. [provided by RefSeq, Nov 2011]
Expression
Ubiquitous expression in bone marrow (RPKM 16.1), appendix (RPKM 8.0) and 24 other tissues See more
Orthologs

Genomic context

See USP15 in Genome Data Viewer
Location:
12q14.1
Exon count:
27
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (62260404..62416389)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (62654121..62803501)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene TAFA chemokine like family member 2 Neighboring gene ribosomal protein S3 pseudogene 6 Neighboring gene Kruppel like factor 17 pseudogene 1 Neighboring gene microRNA 6125 Neighboring gene RNA, U6 small nuclear 595, pseudogene Neighboring gene MON2 homolog, regulator of endosome-to-Golgi trafficking Neighboring gene RNA, U6 small nuclear 399, pseudogene Neighboring gene long intergenic non-protein coding RNA 1465

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of lung function decline in adults with and without asthma.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ55073, KIAA0529, MGC74854, MGC131982, MGC149838

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Lys48-specific deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
cysteine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity IDA
Inferred from Direct Assay
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity TAS
Traceable Author Statement
more info
 
transforming growth factor beta receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin modification-dependent histone binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 15
Names
deubiquitinating enzyme 15
ubiquitin thioesterase 15
ubiquitin thiolesterase 15
ubiquitin-specific-processing protease 15
NP_001239007.1
NP_001239008.1
NP_001338088.1
NP_001338089.1
NP_001338090.1
NP_001338091.1
NP_001338092.1
NP_001338093.1
NP_001338094.1
NP_001338095.1
NP_006304.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252078.2NP_001239007.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 1

    See identical proteins and their annotated locations for NP_001239007.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC079035, AF153604
    Consensus CDS
    CCDS58251.1
    UniProtKB/Swiss-Prot
    Q9Y4E8
    Related
    ENSP00000280377.5, ENST00000280377.10
    Conserved Domains (1) summary
    COG5560
    Location:12932
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
  2. NM_001252079.2NP_001239008.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 3

    See identical proteins and their annotated locations for NP_001239008.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and lacks a large portion of the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AI027693, BC063454
    Consensus CDS
    CCDS58250.1
    UniProtKB/Swiss-Prot
    Q9Y4E8
    Related
    ENSP00000309240.6, ENST00000312635.10
    Conserved Domains (2) summary
    smart00695
    Location:24121
    DUSP; Domain in ubiquitin-specific proteases
    pfam14836
    Location:135222
    Ubiquitin_3; Ubiquitin-like domain
  3. NM_001351159.2NP_001338088.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC048342, AC079035, AC117370
    Conserved Domains (2) summary
    pfam14836
    Location:14101
    Ubiquitin_3; Ubiquitin-like domain
    cl02553
    Location:162811
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  4. NM_001351160.2NP_001338089.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC048342, AC079035, AC117370
    Conserved Domains (1) summary
    COG5560
    Location:34683
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
  5. NM_001351161.2NP_001338090.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC048342, AC079035, AC117370
    Conserved Domains (1) summary
    smart00695
    Location:24116
    DUSP; Domain in ubiquitin-specific proteases
  6. NM_001351162.2NP_001338091.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC048342, AC117370
    Conserved Domains (1) summary
    pfam06337
    Location:2775
    DUSP; DUSP domain
  7. NM_001351163.2NP_001338092.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variants 9-11, encodes isoform 8.
    Source sequence(s)
    AC048342, AC079035, AC117370
    Conserved Domains (1) summary
    COG5560
    Location:1599
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
  8. NM_001351164.2NP_001338093.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 8, 10, and 11, encodes isoform 8.
    Source sequence(s)
    AC048342, AC079035, AC117370
    Conserved Domains (1) summary
    COG5560
    Location:1599
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
  9. NM_001351165.2NP_001338094.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 8, 9, and 11, encodes isoform 8.
    Source sequence(s)
    AC048342, AC079035, AC117370
    Conserved Domains (1) summary
    COG5560
    Location:1599
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
  10. NM_001351166.2NP_001338095.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 8-10, encodes isoform 8.
    Source sequence(s)
    AC048342, AC079035, AC117370
    Conserved Domains (1) summary
    COG5560
    Location:1599
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
  11. NM_006313.3NP_006304.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 2

    See identical proteins and their annotated locations for NP_006304.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC079035, AF106069, BC125123, DB451322
    Consensus CDS
    CCDS8963.1
    UniProtKB/Swiss-Prot
    Q9Y4E8
    Related
    ENSP00000258123.4, ENST00000353364.7
    Conserved Domains (1) summary
    COG5560
    Location:12903
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

RNA

  1. NR_147078.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC048342, AC079035, AC117370
  2. NR_147079.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC048342, AC079035, AC117370
  3. NR_147080.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC048342, AC079035, AC117370
  4. NR_147081.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC048342, AC079035, AC117370
  5. NR_147082.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC048342, AC079035, AC117370

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    62260404..62416389
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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