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HS3ST2 heparan sulfate-glucosamine 3-sulfotransferase 2 [ Homo sapiens (human) ]

Gene ID: 9956, updated on 3-May-2025
Official Symbol
HS3ST2provided by HGNC
Official Full Name
heparan sulfate-glucosamine 3-sulfotransferase 2provided by HGNC
Primary source
HGNC:HGNC:5195
See related
Ensembl:ENSG00000122254 MIM:604056; AllianceGenome:HGNC:5195
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
30ST2; 3OST2
Summary
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. This gene is expressed predominantly in brain and may play a role in the nervous system. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 12.4) and lung (RPKM 0.7) See more
Orthologs
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See HS3ST2 in Genome Data Viewer
Location:
16p12.2
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (22814162..22916338)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (23091844..23194123)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (22825483..22927659)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268175 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:22593503-22594003 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:22635639-22636161 Neighboring gene long intergenic non-protein coding RNA 2890 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:22646396-22646952 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:22646953-22647508 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10574 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:22692364-22693148 Neighboring gene collagen alpha-1(XVI) chain Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:22871179-22871742 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10575 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:22964872-22965382 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:22988092-22988272 Neighboring gene uncharacterized LOC112268176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:23079291-23079792 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:23104917-23105463 Neighboring gene ubiquitin specific peptidase 31 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7271 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7272 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7273 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7274

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
EBI GWAS Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of heparan sulfate (glucosamine) 3-O-sulfotransferase 2 (HS3ST2) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in glycosaminoglycan biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in heparan sulfate proteoglycan biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
heparan sulfate glucosamine 3-O-sulfotransferase 2
Names
3-OST-2
h3-OST-2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
heparan sulfate 3-O-sulfotransferase 2
heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2
heparin-glucosamine 3-O-sulfotransferase
NP_006034.1
XP_011544303.1
XP_054170535.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006043.2NP_006034.1  heparan sulfate glucosamine 3-O-sulfotransferase 2

    See identical proteins and their annotated locations for NP_006034.1

    Status: REVIEWED

    Source sequence(s)
    AC130466, AF105375
    Consensus CDS
    CCDS10606.1
    UniProtKB/Swiss-Prot
    Q52LZ1, Q9Y278
    UniProtKB/TrEMBL
    B2R8Q2
    Related
    ENSP00000261374.3, ENST00000261374.4
    Conserved Domains (1) summary
    pfam00685
    Location:114351
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    22814162..22916338
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011546001.4XP_011544303.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X1

    Conserved Domains (1) summary
    cl21551
    Location:114183
    Sulfotransfer_1; Sulfotransferase domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    23091844..23194123
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054314560.1XP_054170535.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X1