Format

Send to:

Choose Destination

HS3ST2 heparan sulfate-glucosamine 3-sulfotransferase 2 [ Homo sapiens (human) ]

Gene ID: 9956, updated on 14-Jun-2020

Summary

Official Symbol
HS3ST2provided by HGNC
Official Full Name
heparan sulfate-glucosamine 3-sulfotransferase 2provided by HGNC
Primary source
HGNC:HGNC:5195
See related
Ensembl:ENSG00000122254 MIM:604056
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
30ST2; 3OST2
Summary
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. This gene is expressed predominantly in brain and may play a role in the nervous system. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 12.4) and lung (RPKM 0.7) See more
Orthologs

Genomic context

See HS3ST2 in Genome Data Viewer
Location:
16p12.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (22814162..22916338)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (22825860..22927659)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268175 Neighboring gene OTOA pseudogene 1 Neighboring gene uncharacterized LOC107984851 Neighboring gene uncharacterized LOC112268176 Neighboring gene ubiquitin specific peptidase 31

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of heparan sulfate (glucosamine) 3-O-sulfotransferase 2 (HS3ST2) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity IEA
Inferred from Electronic Annotation
more info
 
sulfotransferase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
circadian rhythm IEA
Inferred from Electronic Annotation
more info
 
glycosaminoglycan biosynthetic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
heparan sulfate glucosamine 3-O-sulfotransferase 2
Names
3-OST-2
h3-OST-2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
heparan sulfate 3-O-sulfotransferase 2
heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2
heparin-glucosamine 3-O-sulfotransferase
NP_006034.1
XP_011544303.1
XP_011544304.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006043.2NP_006034.1  heparan sulfate glucosamine 3-O-sulfotransferase 2

    See identical proteins and their annotated locations for NP_006034.1

    Status: REVIEWED

    Source sequence(s)
    AC130466, AF105375
    Consensus CDS
    CCDS10606.1
    UniProtKB/Swiss-Prot
    Q9Y278
    Related
    ENSP00000261374.3, ENST00000261374.4
    Conserved Domains (1) summary
    pfam00685
    Location:114351
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    22814162..22916338
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011546002.3XP_011544304.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X2

    Conserved Domains (1) summary
    cl21551
    Location:114173
    Sulfotransfer_1; Sulfotransferase domain
  2. XM_011546001.3XP_011544303.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X1

    Conserved Domains (1) summary
    cl21551
    Location:114183
    Sulfotransfer_1; Sulfotransferase domain
Support Center