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HS3ST2 heparan sulfate-glucosamine 3-sulfotransferase 2 [ Homo sapiens (human) ]

Gene ID: 9956, updated on 3-May-2025
Official Symbol
HS3ST2provided by HGNC
Official Full Name
heparan sulfate-glucosamine 3-sulfotransferase 2provided by HGNC
Primary source
HGNC:HGNC:5195
See related
Ensembl:ENSG00000122254 MIM:604056; AllianceGenome:HGNC:5195
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
30ST2; 3OST2
Summary
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. This gene is expressed predominantly in brain and may play a role in the nervous system. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 12.4) and lung (RPKM 0.7) See more
Orthologs
mouse all
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See HS3ST2 in Genome Data Viewer
Location:
16p12.2
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (22814162..22916338)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (23091844..23194123)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (22825483..22927659)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268175 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:22593503-22594003 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:22635639-22636161 Neighboring gene long intergenic non-protein coding RNA 2890 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:22646396-22646952 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:22646953-22647508 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10574 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:22692364-22693148 Neighboring gene collagen alpha-1(XVI) chain Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:22871179-22871742 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10575 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:22964872-22965382 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:22988092-22988272 Neighboring gene uncharacterized LOC112268176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:23079291-23079792 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:23104917-23105463 Neighboring gene ubiquitin specific peptidase 31 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7271 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7272 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7273 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7274

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. HS3ST2 expression induces the cell autonomous aggregation of tau. Huynh MB, et al. Sci Rep, 2022 Jun 27. PMID 35760982, Free PMC Article
  2. Heparan sulfate 3-O-sulfotransferase 2 (HS3ST2) displays an unexpected subcellular localization in the plasma membrane. Delos M, et al. Biochim Biophys Acta Gen Subj, 2018 Jul. PMID 29660372
  3. Epigenetic inactivation of heparan sulfate (glucosamine) 3-O-sulfotransferase 2 in lung cancer and its role in tumorigenesis. Hwang JA, et al. PLoS One, 2013. PMID 24265783, Free PMC Article
  4. A role for heparan sulfate 3-O-sulfotransferase isoform 2 in herpes simplex virus type 1 entry and spread. O'Donnell CD, et al. Virology, 2006 Mar 15. PMID 16336986
  5. Possible role of hsa-miR-194-5p, via regulation of HS3ST2, in the pathogenesis of atopic dermatitis in children. Meng L, et al. Eur J Dermatol, 2019 Dec 1. PMID 31903950

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HS3ST2 expression induces the cell autonomous aggregation of tau.
    Title: HS3ST2 expression induces the cell autonomous aggregation of tau.
  2. CpG Islands Methylation Analysis of CDH11, EphA5, and HS3ST2 Genes in Gastric Adenocarcinoma Patients.
    Title: CpG Islands Methylation Analysis of CDH11, EphA5, and HS3ST2 Genes in Gastric Adenocarcinoma Patients.
  3. Hsa-miR-194-5p might be involved in the pathogenesis of atopic dermatitis by regulating HS3ST2 expression.
    Title: Possible role of hsa-miR-194-5p, via regulation of HS3ST2, in the pathogenesis of atopic dermatitis in children.
  4. Methylation status of KLF4 and HS3ST2 genes as predictors of endometrial cancer and hyperplastic endometrial lesio
    Title: Methylation status of KLF4 and HS3ST2 genes as predictors of endometrial cancer and hyperplastic endometrial lesions.
  5. In primary macrophages, HS3ST2 was clearly visualized at the plasma membrane. Its truncated form remained in the Golgi apparatus, meaning that the catalytic domain might support correct addressing of HS3ST2 to cell surface. HS3ST2 partly co-localized with syndecan-2 in HeLa cells and primary macrophages suggesting that this enzyme may participate in discrete processes that occur at the cell surface.
    Title: Heparan sulfate 3-O-sulfotransferase 2 (HS3ST2) displays an unexpected subcellular localization in the plasma membrane.
  6. HS3ST2 and CCNA1 genes may play important roles in HPV-induced cervical cancer and patients with specific hypermethylated genes may have a greater risk of progressing to invasive cervical cancer.
    Title: Methylation in the promoters of HS3ST2 and CCNA1 genes is associated with cervical cancer in Uygur women in Xinjiang.
  7. By interacting with tau at the intracellular level, the 3-O-sulphated heparan sulphates produced by HS3ST2 might act as molecular chaperones allowing the abnormal phosphorylation of tau
    Title: HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer's disease-related tau pathology.
  8. HS3ST2 hypermethylation may be an independent prognostic indicator for overall survival in node-negative stage I-II NSCLC
    Title: Epigenetic inactivation of heparan sulfate (glucosamine) 3-O-sulfotransferase 2 in lung cancer and its role in tumorigenesis.
  9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  10. Observational study and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of heparan sulfate (glucosamine) 3-O-sulfotransferase 2 (HS3ST2) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables [heparan sulfate]-glucosamine 3-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables [heparan sulfate]-glucosamine 3-sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables [heparan sulfate]-glucosamine 3-sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables [heparan sulfate]-glucosamine 3-sulfotransferase activity TAS
Traceable Author Statement
more info
  
enables sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables sulfotransferase activity TAS
Traceable Author Statement
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycosaminoglycan biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heparan sulfate proteoglycan biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
Preferred Names
heparan sulfate glucosamine 3-O-sulfotransferase 2
Names
3-OST-2
h3-OST-2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
heparan sulfate 3-O-sulfotransferase 2
heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2
heparin-glucosamine 3-O-sulfotransferase
NP_006034.1
XP_011544303.1
XP_054170535.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006043.2 → NP_006034.1  heparan sulfate glucosamine 3-O-sulfotransferase 2

    See identical proteins and their annotated locations for NP_006034.1

    Status: REVIEWED

    Source sequence(s)
    AC130466, AF105375
    Consensus CDS
    CCDS10606.1
    UniProtKB/Swiss-Prot
    Q52LZ1, Q9Y278
    UniProtKB/TrEMBL
    B2R8Q2
    Related
    ENSP00000261374.3, ENST00000261374.4
    Conserved Domains (1) summary
    pfam00685
    Location:114 → 351
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    22814162..22916338
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011546001.4 → XP_011544303.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X1

    Conserved Domains (1) summary
    cl21551
    Location:114 → 183
    Sulfotransfer_1; Sulfotransferase domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    23091844..23194123
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054314560.1 → XP_054170535.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y278.1 GenPept UniProtKB/Swiss-Prot:Q9Y278

Gene LinkOut

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