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HS3ST3A1 heparan sulfate-glucosamine 3-sulfotransferase 3A1 [ Homo sapiens (human) ]

Gene ID: 9955, updated on 22-Sep-2022

Summary

Official Symbol
HS3ST3A1provided by HGNC
Official Full Name
heparan sulfate-glucosamine 3-sulfotransferase 3A1provided by HGNC
Primary source
HGNC:HGNC:5196
See related
Ensembl:ENSG00000153976 MIM:604057; AllianceGenome:HGNC:5196
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
3OST3A1; 3-OST-3A
Summary
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. The sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1, and these two enzymes sulfate an identical disaccharide. This gene is widely expressed, with the most abundant expression in liver and placenta. [provided by RefSeq, Dec 2014]
Expression
Broad expression in spleen (RPKM 1.4), ovary (RPKM 1.0) and 20 other tissues See more
Orthologs
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Genomic context

See HS3ST3A1 in Genome Data Viewer
Location:
17p12
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (13494032..13601929, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (13401203..13509113, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (13397349..13505246, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904097 Neighboring gene uncharacterized LOC105371543 Neighboring gene microRNA 548h-3 Neighboring gene uncharacterized LOC105371544 Neighboring gene uncharacterized LOC107985014

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
heparan sulfate glucosamine 3-O-sulfotransferase 3A1
Names
heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
heparan sulfate 3-O-sulfotransferase 3A1
heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1
heparin-glucosamine 3-O-sulfotransferase
NP_006033.1
XP_011522416.1
XP_016880969.1
XP_047293184.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006042.3NP_006033.1  heparan sulfate glucosamine 3-O-sulfotransferase 3A1

    See identical proteins and their annotated locations for NP_006033.1

    Status: REVIEWED

    Source sequence(s)
    AA746890, AC005375, AC005411, AF105376, AK292047, AY358838, BU161930, BU619124
    Consensus CDS
    CCDS11165.1
    UniProtKB/Swiss-Prot
    A8K7N2, Q9Y663
    Related
    ENSP00000284110.1, ENST00000284110.2
    Conserved Domains (1) summary
    pfam00685
    Location:152389
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    13494032..13601929 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524114.4XP_011522416.1  heparan sulfate glucosamine 3-O-sulfotransferase 3A1 isoform X2

    Conserved Domains (1) summary
    pfam00685
    Location:30190
    Sulfotransfer_1; Sulfotransferase domain
  2. XM_047437228.1XP_047293184.1  heparan sulfate glucosamine 3-O-sulfotransferase 3A1 isoform X2

  3. XM_017025480.3XP_016880969.1  heparan sulfate glucosamine 3-O-sulfotransferase 3A1 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    13401203..13509113 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)