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GOLGA5 golgin A5 [ Homo sapiens (human) ]

Gene ID: 9950, updated on 1-Jun-2020

Summary

Official Symbol
GOLGA5provided by HGNC
Official Full Name
golgin A5provided by HGNC
Primary source
HGNC:HGNC:4428
See related
Ensembl:ENSG00000066455 MIM:606918
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RFG5; GOLIM5; ret-II
Summary
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes one of the golgins, a family of proteins localized to the Golgi. This protein is a coiled-coil membrane protein that has been postulated to play a role in vesicle tethering and docking. Translocations involving this gene and the ret proto-oncogene have been found in tumor tissues; the chimeric sequences have been designated RET-II and PTC5. A pseudogene of this gene is located on the short arm of chromosome 5. [provided by RefSeq, Jul 2013]
Expression
Ubiquitous expression in testis (RPKM 23.6), thyroid (RPKM 21.8) and 25 other tissues See more
Orthologs

Genomic context

See GOLGA5 in Genome Data Viewer
Location:
14q32.12
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (92794305..92839947)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (93260576..93306308)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene Ras and Rab interactor 3 Neighboring gene legumain Neighboring gene long intergenic non-protein coding RNA 2833 Neighboring gene long intergenic non-protein coding RNA 2287

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rab GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Golgi vesicle transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
retrograde transport, vesicle recycling within Golgi IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi cisterna IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi cisterna IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
 
cis-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
transport vesicle TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
golgin subfamily A member 5
Names
RET-fused gene 5 protein
cell proliferation-inducing gene 31 protein
golgi autoantigen, golgin subfamily a, 5
golgi integral membrane protein 5
golgin-84

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023248.2 RefSeqGene

    Range
    4927..50659
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005113.4NP_005104.4  golgin subfamily A member 5

    Status: REVIEWED

    Source sequence(s)
    AL132987
    Consensus CDS
    CCDS9905.1
    Related
    ENSP00000163416.2, ENST00000163416.7
    Conserved Domains (2) summary
    pfam09787
    Location:420725
    Golgin_A5; Golgin subfamily A member 5
    cl25732
    Location:219570
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    92794305..92839947
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537420.3XP_011535722.1  golgin subfamily A member 5 isoform X1

    UniProtKB/Swiss-Prot
    Q8TBA6
    Conserved Domains (2) summary
    pfam09787
    Location:235683
    Golgin_A5; Golgin subfamily A member 5
    cl23720
    Location:479575
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
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