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CDC25C cell division cycle 25C [ Homo sapiens (human) ]

Gene ID: 995, updated on 22-Aug-2020

Summary

Official Symbol
CDC25Cprovided by HGNC
Official Full Name
cell division cycle 25Cprovided by HGNC
Primary source
HGNC:HGNC:1727
See related
Ensembl:ENSG00000158402 MIM:157680
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDC25; PPP1R60
Summary
This gene encodes a conserved protein that plays a key role in the regulation of cell division. The encoded protein directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It also suppresses p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Dec 2015]
Expression
Biased expression in testis (RPKM 7.7), bone marrow (RPKM 1.3) and 8 other tissues See more
Orthologs

Genomic context

See CDC25C in Genome Data Viewer
Location:
5q31.2
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (138285265..138338355, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (137620959..137674064, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 7870 Neighboring gene GDNF family receptor alpha 3 Neighboring gene RPS27A pseudogene 18 Neighboring gene uncharacterized LOC100128966 Neighboring gene family with sequence similarity 53 member C Neighboring gene lysine demethylase 3B Neighboring gene receptor accessory protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Biological insights from 108 schizophrenia-associated genetic loci.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 decreases adult neural progenitor cell proliferation via the p38 MAPK-MAPKAPK2-Cdc25C signaling pathway PubMed
Tat tat The DNA repair gene DNA-PKcs and cell cycle-related genes Cdc20, Cdc25C, KIF2C and CTS1 are downregulated in HIV-1 Tat-expressing human rhabdomyosarcoma cells PubMed
Vpr vpr Kinase Srk1 is required for the Vpr-mediated nuclear export of Cdc25 PubMed
vpr HIV-1 Vpr induces subcellular relocalization of Cdc25 from nuclear to cytoplasm and Vpr-induced nuclear exclusion of Cdc25 depends on the serine/threonine phosphorylation of Cdc25 and the presence of Rad24/14-3-3 protein PubMed
vpr Vpr-induced cell cycle G2/M arrest reveals a dramatic increase in the amount of Cdk1, Cdc25C, and CyclinB1 bound to 14-3-3 theta PubMed
vpr Binding of Cdc25c to HIV-1 Vpr is required for Vpr-mediated G2 arrest in HeLa cells PubMed
vpr A minimal domain between amino acids 334 and 379 of Cdc25c, upstream of its catalytic site, is sufficient to bind HIV-1 Vpr; mutation at residue E352 of Cdc25c greatly reduces binding of Vpr to Cdc25c PubMed
vpr HIV-1 Vpr forms a triple complex with 14-3-3 eta and Cdc25C and thereby promotes cell cycle arrest at the G(2)/M phase by facilitating association of 14-3-3 and Cdc25C PubMed
vpr Rupture of HIV-1 Vpr-induced nuclear envelope herniations produces transient loss of the subcellular compartmentalization of Wee1, Cdc25C, cyclin B1, and presumably other soluble cellular components, resulting in their release into the cytoplasm PubMed
vpr The human Vpr interacting protein (hVIP/MOV34) is a likely cellular cofactor for HIV-1 Vpr inactivation of the cdc2-cyclin B kinase complex through Cdc25c and induction of cell cycle arrest PubMed
vpr Inactivation of the cdc2-cyclin B kinase complex through Cdc25c and arrest in the G2 phase of the cell cycle has been mapped to the C-terminus of HIV-1 Vpr, including amino acids 73, 80 and 84-96 PubMed
vpr HIV-1 Vpr inactivates the cdc2-cyclin B kinase complex by inactivating cdc25C, the phosphatase that dephosphorylates and activates cdc2 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
WW domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein tyrosine phosphatase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
Traceable Author Statement
more info
 
G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G2/M transition of mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of G2/MI transition of meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cyclin-dependent protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
regulation of mitotic nuclear division TAS
Traceable Author Statement
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
M-phase inducer phosphatase 3
Names
dual specificity phosphatase CDC25C
mitosis inducer CDC25
phosphotyrosine phosphatase
protein phosphatase 1, regulatory subunit 60
NP_001274511.1
NP_001274512.1
NP_001305027.1
NP_001350955.1
NP_001350956.1
NP_001350957.1
NP_001781.2
NP_073720.1
XP_005272202.1
XP_006714802.1
XP_011542061.1
XP_011542062.1
XP_011542063.1
XP_011542064.1
XP_011542065.1
XP_011542066.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287582.2NP_001274511.1  M-phase inducer phosphatase 3 isoform a

    See identical proteins and their annotated locations for NP_001274511.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same protein (isoform a).
    Source sequence(s)
    AK097710, AU125025, AW512559, BC019089, DB449713
    Consensus CDS
    CCDS4202.1
    UniProtKB/Swiss-Prot
    P30307
    Related
    ENSP00000424795.1, ENST00000513970.5
    Conserved Domains (2) summary
    cd01530
    Location:302421
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:210244
    M-inducer_phosp; M-phase inducer phosphatase
  2. NM_001287583.2NP_001274512.1  M-phase inducer phosphatase 3 isoform c

    See identical proteins and their annotated locations for NP_001274512.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, uses an alternate splice site in the 5' region, and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (c) has a longer N-terminus than isoform a.
    Source sequence(s)
    AK097710, AW512559, DB516402
    Conserved Domains (2) summary
    cd01530
    Location:380499
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:288322
    M-inducer_phosp; M-phase inducer phosphatase
  3. NM_001318098.2NP_001305027.1  M-phase inducer phosphatase 3 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (e) has a longer N-terminus than isoform 1.
    Source sequence(s)
    AK097710, AK301828, AW512559, BC019089
    UniProtKB/Swiss-Prot
    P30307
    UniProtKB/TrEMBL
    B4DX61
    Conserved Domains (2) summary
    cd01530
    Location:319438
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:227261
    M-inducer_phosp; M-phase inducer phosphatase
  4. NM_001364026.1NP_001350955.1  M-phase inducer phosphatase 3 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC104116
    Conserved Domains (2) summary
    COG5105
    Location:222504
    MIH1; Mitotic inducer, protein phosphatase [Cell division and chromosome partitioning]
    cd01530
    Location:367478
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
  5. NM_001364027.1NP_001350956.1  M-phase inducer phosphatase 3 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC104116
    Conserved Domains (2) summary
    COG5105
    Location:144413
    MIH1; Mitotic inducer, protein phosphatase [Cell division and chromosome partitioning]
    cd01530
    Location:268387
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
  6. NM_001364028.1NP_001350957.1  M-phase inducer phosphatase 3 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC104116
    Conserved Domains (2) summary
    COG5105
    Location:36404
    MIH1; Mitotic inducer, protein phosphatase [Cell division and chromosome partitioning]
    cd01530
    Location:259378
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
  7. NM_001790.5NP_001781.2  M-phase inducer phosphatase 3 isoform a

    See identical proteins and their annotated locations for NP_001781.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a. Variants 1 and 3 encode the same protein (isoform a).
    Source sequence(s)
    AC104116, AW512559, DB040755, M34065
    Consensus CDS
    CCDS4202.1
    UniProtKB/Swiss-Prot
    P30307
    Related
    ENSP00000321656.6, ENST00000323760.11
    Conserved Domains (2) summary
    cd01530
    Location:302421
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:210244
    M-inducer_phosp; M-phase inducer phosphatase
  8. NM_022809.4NP_073720.1  M-phase inducer phosphatase 3 isoform b

    See identical proteins and their annotated locations for NP_073720.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as cdc25Cdm) lacks three exons in the 5' coding region, resulting in a short region of frameshift, compared to variant 4. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AC104116, AJ304504, AU098899, AW512559
    Consensus CDS
    CCDS4203.1
    UniProtKB/Swiss-Prot
    P30307
    Related
    ENSP00000345205.3, ENST00000348983.7
    Conserved Domains (2) summary
    cd01530
    Location:229348
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:137171
    M-inducer_phosp; M-phase inducer phosphatase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    138285265..138338355 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543761.2XP_011542063.1  M-phase inducer phosphatase 3 isoform X4

    Conserved Domains (2) summary
    cd01530
    Location:307426
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:215249
    M-inducer_phosp; M-phase inducer phosphatase
  2. XM_011543760.2XP_011542062.1  M-phase inducer phosphatase 3 isoform X3

    Conserved Domains (2) summary
    cd01530
    Location:333444
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:288322
    M-inducer_phosp; M-phase inducer phosphatase
  3. XM_005272145.3XP_005272202.1  M-phase inducer phosphatase 3 isoform X1

    Conserved Domains (2) summary
    cd01530
    Location:346465
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:288322
    M-inducer_phosp; M-phase inducer phosphatase
  4. XM_006714739.3XP_006714802.1  M-phase inducer phosphatase 3 isoform X5

    Conserved Domains (2) summary
    cd01530
    Location:304423
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:212246
    M-inducer_phosp; M-phase inducer phosphatase
  5. XM_011543759.3XP_011542061.1  M-phase inducer phosphatase 3 isoform X2

    Conserved Domains (2) summary
    cd01530
    Location:326445
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:234268
    M-inducer_phosp; M-phase inducer phosphatase
  6. XM_011543762.1XP_011542064.1  M-phase inducer phosphatase 3 isoform X7

    See identical proteins and their annotated locations for XP_011542064.1

    UniProtKB/Swiss-Prot
    P30307
    Related
    ENSP00000392631.2, ENST00000415130.6
    Conserved Domains (2) summary
    cd01530
    Location:229348
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:137171
    M-inducer_phosp; M-phase inducer phosphatase
  7. XM_011543764.1XP_011542066.1  M-phase inducer phosphatase 3 isoform X9

    Conserved Domains (2) summary
    cd01530
    Location:140259
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:48107
    M-inducer_phosp; M-phase inducer phosphatase
  8. XM_011543763.1XP_011542065.1  M-phase inducer phosphatase 3 isoform X8

    Conserved Domains (2) summary
    cd01530
    Location:191310
    Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
    pfam06617
    Location:99133
    M-inducer_phosp; M-phase inducer phosphatase
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