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MAGEC1 MAGE family member C1 [ Homo sapiens (human) ]

Gene ID: 9947, updated on 4-Jul-2021

Summary

Official Symbol
MAGEC1provided by HGNC
Official Full Name
MAGE family member C1provided by HGNC
Primary source
HGNC:HGNC:6812
See related
Ensembl:ENSG00000155495 MIM:300223
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT7; CT7.1
Summary
This gene is a member of the melanoma antigen gene (MAGE) family. The proteins of this family are tumor-specific antigens that can be recognized by autologous cytolytic T lymphocytes. This protein contains a large number of unique short repetitive sequences in front of the MAGE-homologous sequence, and therefore is about 800 aa longer than the other MAGE proteins. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 5.4) See more
Orthologs
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Genomic context

See MAGEC1 in Genome Data Viewer
Location:
Xq27.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (141903877..141909401)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (140991680..140997160)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene SPANX family member D Neighboring gene MAGE family member C3 Neighboring gene MAGE family member A10 pseudogene Neighboring gene MAGE family member C2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC39366

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
melanoma-associated antigen C1
Names
MAGE-C1 antigen
cancer/testis antigen 7.1
cancer/testis antigen family 7, member 1
melanoma antigen family C, 1
melanoma antigen family C1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_015871.1 RefSeqGene

    Range
    5039..10519
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005462.5NP_005453.2  melanoma-associated antigen C1

    See identical proteins and their annotated locations for NP_005453.2

    Status: REVIEWED

    Source sequence(s)
    AF056334, AL022152, BQ772869
    Consensus CDS
    CCDS35417.1
    UniProtKB/Swiss-Prot
    O60732
    Related
    ENSP00000285879.4, ENST00000285879.5
    Conserved Domains (1) summary
    pfam01454
    Location:9151082
    MAGE; MAGE family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    141903877..141909401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531418.2XP_011529720.1  melanoma-associated antigen C1 isoform X1

    See identical proteins and their annotated locations for XP_011529720.1

    UniProtKB/Swiss-Prot
    O60732
    Conserved Domains (1) summary
    pfam01454
    Location:9151082
    MAGE; MAGE family
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